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AGAA - Putative N-acetylgalactosamine-6-phosphate deacetylase
UniProt: P42906 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12766
Length: 167 (164)
Sequences: 1340
Seq/Len: 8.17

AGAA
Paralog alert: 0.28 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
97_L 102_A 3.681 1.00
135_L 143_R 3.572 1.00
137_S 142_K 3.435 1.00
150_D 154_H 3.158 1.00
138_L 146_V 2.944 1.00
3_C 46_C 2.431 1.00
103_V 121_A 2.285 1.00
10_L 19_G 2.217 1.00
70_R 77_E 2.157 1.00
33_A 43_M 2.052 1.00
56_L 121_A 2.007 1.00
58_T 99_V 1.977 1.00
98_S 101_A 1.932 1.00
159_W 164_L 1.816 1.00
157_Q 164_L 1.792 1.00
50_A 53_R 1.771 1.00
8_T 14_E 1.766 1.00
80_M 85_V 1.764 1.00
6_G 91_G 1.759 1.00
21_G 29_L 1.743 1.00
123_L 132_D 1.71 1.00
31_L 54_I 1.649 1.00
47_C 120_M 1.624 1.00
150_D 156_Q 1.612 1.00
118_I 122_S 1.6 1.00
100_D 104_R 1.551 1.00
10_L 42_A 1.533 1.00
149_L 153_L 1.527 1.00
105_N 109_L 1.518 1.00
33_A 106_M 1.51 1.00
12_H 42_A 1.507 1.00
139_K 142_K 1.469 0.99
147_V 155_V 1.469 0.99
107_V 117_A 1.411 0.99
63_A 80_M 1.407 0.99
23_T 44_S 1.404 0.99
72_T 75_G 1.397 0.99
52_E 119_H 1.384 0.99
134_V 143_R 1.378 0.99
63_A 74_C 1.362 0.99
33_A 56_L 1.337 0.99
102_A 106_M 1.336 0.99
127_R 137_S 1.308 0.98
55_V 124_H 1.308 0.98
119_H 123_L 1.283 0.98
70_R 79_Q 1.282 0.98
38_V 42_A 1.271 0.98
113_T 116_E 1.269 0.98
104_R 154_H 1.259 0.98
31_L 43_M 1.254 0.98
61_M 73_L 1.232 0.97
4_Y 42_A 1.219 0.97
11_H 14_E 1.193 0.97
143_R 161_Q 1.183 0.97
72_T 77_E 1.182 0.96
29_L 50_A 1.181 0.96
55_V 128_M 1.18 0.96
3_C 29_L 1.164 0.96
8_T 17_M 1.16 0.96
123_L 127_R 1.16 0.96
60_A 64_A 1.159 0.96
66_M 69_G 1.148 0.96
21_G 50_A 1.147 0.96
22_L 49_C 1.145 0.96
114_P 153_L 1.125 0.95
4_Y 46_C 1.117 0.95
47_C 54_I 1.111 0.95
131_V 135_L 1.095 0.94
127_R 132_D 1.088 0.94
30_E 57_I 1.08 0.93
25_K 48_C 1.078 0.93
35_G 109_L 1.075 0.93
23_T 45_L 1.073 0.93
121_A 125_P 1.07 0.93
58_T 97_L 1.064 0.93
22_L 50_A 1.058 0.92
147_V 158_I 1.056 0.92
84_V 92_L 1.056 0.92
63_A 73_L 1.055 0.92
29_L 46_C 1.052 0.92
36_H 84_V 1.044 0.92
13_R 16_G 1.037 0.91
15_P 39_H 1.036 0.91
135_L 145_S 1.031 0.91
58_T 98_S 1.019 0.91
23_T 49_C 1.009 0.90
3_C 21_G 1.008 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3iv8A411000.399Contact Map0.863
1yrrA211000.405Contact Map0.839
2vhlA211000.418Contact Map0.795
1o12A20.9941000.462Contact Map0.813
3gipA20.970199.90.618Contact Map0.394
1onwA20.886299.90.633Contact Map0.664
2ftwA10.946199.90.636Contact Map0.426
2vr2A10.970199.80.653Contact Map0.476
2vm8A40.970199.80.663Contact Map0.557
3dc8A20.940199.80.666Contact Map0.544

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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