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AGAS - Putative tagatose-6-phosphate ketose/aldose isomerase
UniProt: P42907 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12767
Length: 384 (341)
Sequences: 2452
Seq/Len: 7.19

AGAS
Paralog alert: 0.39 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: AGAS FRLB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
54_L 104_P 4.94 1.00
27_W 204_C 3.965 1.00
137_P 150_A 3.893 1.00
124_E 149_N 3.793 1.00
25_R 29_R 3.51 1.00
172_M 175_S 3.47 1.00
205_Q 209_T 3.263 1.00
58_L 68_G 3.221 1.00
27_W 181_A 2.968 1.00
68_G 110_F 2.695 1.00
109_S 123_V 2.636 1.00
176_I 238_A 2.612 1.00
211_L 352_M 2.599 1.00
28_I 205_Q 2.514 1.00
206_A 209_T 2.482 1.00
110_F 183_C 2.477 1.00
243_A 256_A 2.36 1.00
54_L 102_A 2.359 1.00
55_R 84_S 2.245 1.00
204_C 344_M 2.231 1.00
125_L 128_Q 2.139 1.00
127_N 151_I 2.11 1.00
53_N 106_L 2.076 1.00
106_L 136_L 1.985 1.00
111_G 146_L 1.966 1.00
355_L 361_P 1.951 1.00
107_L 126_A 1.923 1.00
21_R 211_L 1.907 1.00
222_A 323_P 1.9 1.00
242_S 346_A 1.896 1.00
213_D 217_G 1.894 1.00
206_A 314_E 1.894 1.00
25_R 205_Q 1.88 1.00
221_Y 356_H 1.86 1.00
240_R 258_Y 1.815 1.00
222_A 307_R 1.743 1.00
58_L 83_F 1.74 1.00
75_L 83_F 1.737 1.00
107_L 133_C 1.73 1.00
71_I 183_C 1.718 1.00
26_A 178_T 1.704 1.00
200_V 340_F 1.696 1.00
56_I 108_I 1.671 1.00
87_P 260_S 1.664 1.00
75_L 187_F 1.66 1.00
139_T 147_Y 1.659 1.00
23_Q 177_T 1.648 1.00
315_S 326_I 1.641 1.00
327_L 342_F 1.639 1.00
135_H 150_A 1.627 1.00
210_S 215_S 1.622 1.00
72_A 76_A 1.617 1.00
65_A 69_D 1.579 1.00
123_V 146_L 1.579 1.00
196_T 203_R 1.572 1.00
17_E 21_R 1.572 1.00
102_A 105_L 1.561 1.00
236_Q 240_R 1.552 1.00
199_D 202_D 1.551 1.00
137_P 146_L 1.527 0.99
280_V 296_L 1.521 0.99
56_I 106_L 1.515 0.99
282_V 296_L 1.503 0.99
352_M 356_H 1.489 0.99
285_H 335_D 1.468 0.99
247_L 257_F 1.458 0.99
317_D 320_A 1.446 0.99
202_D 205_Q 1.434 0.99
218_V 221_Y 1.434 0.99
196_T 334_I 1.401 0.99
199_D 203_R 1.401 0.99
238_A 343_L 1.392 0.99
74_W 184_L 1.39 0.99
312_A 319_V 1.39 0.99
109_S 135_H 1.379 0.99
241_E 245_K 1.378 0.99
215_S 218_V 1.374 0.99
312_A 326_I 1.373 0.99
225_K 273_D 1.359 0.98
58_L 108_I 1.338 0.98
299_L 308_V 1.321 0.98
117_P 121_A 1.316 0.98
180_M 340_F 1.304 0.98
217_G 352_M 1.293 0.98
281_F 346_A 1.284 0.98
279_V 349_F 1.28 0.98
57_I 105_L 1.267 0.97
311_I 327_L 1.262 0.97
265_R 298_E 1.261 0.97
176_I 343_L 1.259 0.97
225_K 357_M 1.235 0.97
195_Q 199_D 1.216 0.96
230_L 299_L 1.214 0.96
17_E 351_L 1.214 0.96
200_V 341_C 1.208 0.96
56_I 81_K 1.205 0.96
59_T 107_L 1.201 0.96
225_K 275_E 1.193 0.96
227_I 279_V 1.189 0.96
176_I 237_G 1.17 0.95
30_S 161_M 1.169 0.95
307_R 323_P 1.167 0.95
124_E 128_Q 1.167 0.95
207_I 341_C 1.164 0.95
55_R 105_L 1.159 0.95
165_T 174_S 1.159 0.95
30_S 182_S 1.153 0.95
349_F 353_Q 1.152 0.95
217_G 356_H 1.152 0.95
137_P 158_A 1.152 0.95
229_Y 246_V 1.146 0.94
289_R 293_L 1.145 0.94
115_N 145_A 1.143 0.94
134_Y 151_I 1.14 0.94
242_S 281_F 1.135 0.94
80_G 98_Y 1.13 0.94
143_A 147_Y 1.128 0.94
203_R 207_I 1.121 0.94
272_V 278_V 1.119 0.93
76_A 94_N 1.117 0.93
333_F 341_C 1.117 0.93
230_L 280_V 1.117 0.93
55_R 82_N 1.116 0.93
34_I 185_A 1.114 0.93
138_I 183_C 1.111 0.93
80_G 96_M 1.111 0.93
315_S 329_P 1.111 0.93
79_T 187_F 1.11 0.93
203_R 333_F 1.107 0.93
26_A 30_S 1.105 0.93
348_T 352_M 1.099 0.93
120_V 145_A 1.098 0.93
15_W 18_E 1.097 0.93
196_T 199_D 1.096 0.93
203_R 341_C 1.095 0.92
297_A 300_R 1.091 0.92
91_L 99_L 1.09 0.92
194_S 198_R 1.086 0.92
109_S 126_A 1.078 0.92
72_A 84_S 1.072 0.91
78_H 336_V 1.07 0.91
64_S 139_T 1.067 0.91
218_V 222_A 1.063 0.91
59_T 91_L 1.059 0.91
80_G 83_F 1.05 0.90
61_A 116_S 1.035 0.89
99_L 133_C 1.034 0.89
320_A 326_I 1.034 0.89
235_L 281_F 1.031 0.89
171_A 249_L 1.03 0.89
63_T 172_M 1.03 0.89
108_I 186_V 1.019 0.88
291_Y 316_S 1.015 0.88
161_M 178_T 1.015 0.88
146_L 150_A 1.012 0.88
118_E 265_R 1.012 0.88
52_E 104_P 1.01 0.88
167_D 173_T 1.01 0.88
54_L 105_L 1.009 0.88
290_Q 293_L 1.002 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c3jA60.9741000.205Contact Map0.67
3odpA10.98181000.208Contact Map0.647
3i0zA20.9871000.219Contact Map0.732
2zj3A10.91411000.272Contact Map0.826
2pocA40.89581000.278Contact Map0.857
1moqA10.90891000.283Contact Map0.719
3tbfA80.90361000.287Contact Map0.799
3knzA60.91411000.293Contact Map0.742
1j5xA10.8881000.294Contact Map0.658
3fj1A40.87761000.295Contact Map0.713

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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