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AGAI - Putative galactosamine-6-phosphate isomerase
UniProt: P42912 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12772
Length: 251 (232)
Sequences: 2369
Seq/Len: 10.21

AGAI
Paralog alert: 0.34 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: AGAI NAGB YIEK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
101_T 105_Q 3.23 1.00
130_E 133_R 2.764 1.00
65_Y 68_E 2.554 1.00
136_N 140_R 2.526 1.00
104_Q 109_Q 2.515 1.00
121_F 196_I 2.338 1.00
153_K 217_G 2.328 1.00
222_T 249_I 2.257 1.00
208_E 244_N 2.25 1.00
105_Q 109_Q 2.149 1.00
76_D 112_G 2.101 1.00
119_I 137_L 2.096 1.00
27_N 30_A 2.001 1.00
39_L 62_T 1.993 1.00
93_L 100_E 1.962 1.00
132_E 136_N 1.927 1.00
220_D 224_R 1.921 1.00
58_T 212_L 1.852 1.00
145_D 207_R 1.837 1.00
42_V 208_E 1.803 1.00
31_L 214_T 1.802 1.00
33_E 65_Y 1.773 1.00
82_F 108_V 1.77 1.00
28_Y 32_S 1.742 1.00
81_T 119_I 1.731 1.00
223_D 227_T 1.708 1.00
100_E 104_Q 1.675 1.00
54_A 85_L 1.673 1.00
177_A 181_Q 1.665 1.00
129_T 133_R 1.656 1.00
204_L 238_F 1.616 1.00
32_S 61_L 1.616 1.00
147_C 206_A 1.61 1.00
37_E 69_K 1.6 1.00
42_V 49_A 1.595 1.00
151_L 213_V 1.592 1.00
40_L 69_K 1.588 1.00
169_A 205_N 1.583 1.00
213_V 222_T 1.578 1.00
25_V 34_R 1.577 1.00
38_Y 248_L 1.573 1.00
100_E 120_S 1.573 1.00
78_S 112_G 1.564 1.00
39_L 51_I 1.529 1.00
35_A 62_T 1.511 1.00
81_T 117_Q 1.502 1.00
164_E 171_H 1.488 1.00
84_K 103_L 1.482 1.00
60_L 106_H 1.482 1.00
62_T 148_V 1.442 1.00
133_R 137_L 1.433 1.00
83_V 141_K 1.413 1.00
187_T 190_R 1.412 1.00
155_G 234_I 1.41 1.00
158_G 203_I 1.396 0.99
174_Q 194_R 1.393 0.99
151_L 225_F 1.383 0.99
40_L 75_V 1.336 0.99
209_V 245_F 1.335 0.99
138_I 144_L 1.331 0.99
96_P 101_T 1.33 0.99
188_A 191_P 1.32 0.99
25_V 31_L 1.316 0.99
198_L 202_D 1.314 0.99
28_Y 61_L 1.303 0.99
113_L 117_Q 1.294 0.99
52_C 147_C 1.287 0.99
37_E 41_A 1.269 0.99
89_V 127_N 1.266 0.99
225_F 247_C 1.256 0.99
43_I 80_L 1.256 0.99
108_V 118_L 1.251 0.99
38_Y 208_E 1.226 0.98
64_H 106_H 1.22 0.98
25_V 248_L 1.217 0.98
60_L 64_H 1.207 0.98
187_T 192_V 1.207 0.98
43_I 49_A 1.204 0.98
133_R 136_N 1.204 0.98
48_N 81_T 1.2 0.98
68_E 72_Q 1.198 0.98
104_Q 115_E 1.196 0.98
70_I 74_Q 1.188 0.98
94_T 101_T 1.186 0.98
44_R 74_Q 1.181 0.98
224_R 234_I 1.174 0.98
127_N 172_I 1.166 0.97
31_L 248_L 1.157 0.97
122_R 130_E 1.147 0.97
222_T 247_C 1.143 0.97
222_T 225_F 1.141 0.97
81_T 114_R 1.139 0.97
57_A 102_F 1.138 0.97
98_T 101_T 1.132 0.97
35_A 212_L 1.131 0.97
62_T 212_L 1.13 0.97
52_C 85_L 1.129 0.97
38_Y 210_L 1.119 0.96
188_A 192_V 1.105 0.96
115_E 118_L 1.104 0.96
35_A 248_L 1.103 0.96
23_Q 248_L 1.097 0.96
28_Y 214_T 1.096 0.96
91_L 94_T 1.095 0.96
139_A 205_N 1.089 0.96
40_L 44_R 1.089 0.96
114_R 117_Q 1.083 0.96
58_T 214_T 1.078 0.95
50_V 83_V 1.075 0.95
49_A 80_L 1.074 0.95
39_L 146_L 1.063 0.95
135_T 202_D 1.06 0.95
65_Y 69_K 1.058 0.95
35_A 210_L 1.058 0.95
102_F 106_H 1.057 0.95
50_V 81_T 1.057 0.95
144_L 147_C 1.038 0.94
136_N 139_A 1.033 0.94
76_D 79_Q 1.031 0.94
128_E 132_E 1.031 0.94
104_Q 118_L 1.028 0.94
135_T 139_A 1.016 0.93
146_L 210_L 1.013 0.93
59_P 63_Y 1.006 0.93
67_V 110_P 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3oc6A10.90041000.174Contact Map0.709
3tx2A10.90041000.177Contact Map0.695
3icoA40.95621000.185Contact Map0.739
3eb9A20.88841000.198Contact Map0.737
1vl1A10.90441000.2Contact Map0.712
3lwdA10.86451000.222Contact Map0.573
3e15A40.98411000.229Contact Map0.705
3cssA10.89241000.241Contact Map0.63
3lhiA10.88841000.253Contact Map0.556
1y89A20.88051000.267Contact Map0.725

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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