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YHDZ - Uncharacterized amino-acid ABC transporter ATP-binding protein YhdZ
UniProt: P45769 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12837
Length: 252 (239)
Sequences: 70943
Seq/Len: 296.83

YHDZ
Paralog alert: 0.94 [within 20: 0.87] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_V 214_A 3.283 1.00
14_T 34_T 3.091 1.00
39_E 216_R 3.044 1.00
140_H 143_K 2.935 1.00
68_R 75_E 2.917 1.00
16_E 68_R 2.909 1.00
17_N 30_N 2.867 1.00
41_I 218_I 2.766 1.00
89_E 167_K 2.755 1.00
26_H 29_K 2.725 1.00
14_T 70_V 2.638 1.00
133_E 138_A 2.552 1.00
29_K 224_E 2.479 1.00
36_Q 39_E 2.418 1.00
216_R 228_Q 2.364 1.00
127_L 165_K 2.281 1.00
19_N 30_N 2.276 1.00
229_A 233_E 2.23 1.00
21_W 26_H 2.224 1.00
15_L 18_V 2.207 1.00
72_D 167_K 2.201 1.00
20_K 57_C 2.192 1.00
19_N 26_H 2.115 1.00
230_A 233_E 2.053 1.00
105_V 148_I 2.051 1.00
129_V 141_A 2.039 1.00
19_N 66_Q 2.036 1.00
132_L 141_A 1.992 1.00
106_L 142_H 1.975 1.00
218_I 225_I 1.963 1.00
16_E 70_V 1.894 1.00
106_L 141_A 1.85 1.00
37_P 167_K 1.816 1.00
39_E 215_D 1.773 1.00
106_L 129_V 1.759 1.00
17_N 32_N 1.737 1.00
22_Y 27_V 1.717 1.00
218_I 228_Q 1.696 1.00
134_R 192_G 1.676 1.00
165_K 198_M 1.667 1.00
20_K 65_Q 1.646 1.00
106_L 128_A 1.619 1.00
127_L 130_H 1.609 1.00
120_P 123_E 1.578 1.00
134_R 196_S 1.575 1.00
130_H 134_R 1.574 1.00
125_E 129_V 1.57 1.00
143_K 147_Q 1.502 1.00
95_Q 150_G 1.49 1.00
70_V 75_E 1.473 1.00
192_G 196_S 1.463 1.00
106_L 125_E 1.436 1.00
106_L 110_T 1.416 1.00
20_K 62_E 1.413 1.00
21_W 65_Q 1.408 1.00
16_E 34_T 1.407 0.99
55_I 203_V 1.406 0.99
110_T 128_A 1.393 0.99
194_A 215_D 1.391 0.99
110_T 124_A 1.368 0.99
229_A 234_F 1.362 0.99
57_C 64_H 1.353 0.99
126_D 130_H 1.352 0.99
28_L 57_C 1.35 0.99
35_V 41_I 1.347 0.99
204_T 210_A 1.341 0.99
15_L 58_I 1.338 0.99
33_L 218_I 1.325 0.99
138_A 141_A 1.324 0.99
72_D 89_E 1.319 0.99
19_N 29_K 1.311 0.99
12_M 72_D 1.31 0.99
75_E 78_E 1.292 0.99
41_I 228_Q 1.278 0.99
171_F 190_M 1.265 0.99
15_L 33_L 1.248 0.99
108_N 160_R 1.236 0.98
109_C 163_C 1.235 0.98
18_V 64_H 1.231 0.98
129_V 133_E 1.222 0.98
104_T 107_Q 1.211 0.98
105_V 156_V 1.206 0.98
16_E 32_N 1.201 0.98
22_Y 53_T 1.198 0.98
55_I 170_L 1.193 0.98
127_L 131_Y 1.185 0.98
40_R 194_A 1.171 0.98
40_R 200_M 1.167 0.97
191_I 194_A 1.145 0.97
240_S 243_T 1.145 0.97
79_D 82_N 1.143 0.97
36_Q 216_R 1.141 0.97
129_V 138_A 1.14 0.97
131_Y 163_C 1.13 0.97
54_T 220_M 1.122 0.97
15_L 54_T 1.111 0.96
58_I 201_L 1.111 0.96
140_H 152_Q 1.106 0.96
110_T 125_E 1.104 0.96
189_T 192_G 1.098 0.96
226_V 240_S 1.096 0.96
56_R 62_E 1.092 0.96
31_I 54_T 1.089 0.96
37_P 72_D 1.083 0.96
171_F 200_M 1.082 0.96
20_K 53_T 1.081 0.95
183_V 209_F 1.067 0.95
59_N 92_M 1.067 0.95
187_L 209_F 1.063 0.95
167_K 198_M 1.06 0.95
194_A 200_M 1.057 0.95
148_I 156_V 1.053 0.95
93_V 158_I 1.052 0.95
135_V 159_A 1.051 0.94
123_E 126_D 1.048 0.94
169_M 200_M 1.046 0.94
57_C 69_I 1.039 0.94
130_H 133_E 1.035 0.94
144_F 147_Q 1.022 0.93
107_Q 110_T 1.021 0.93
41_I 216_R 1.019 0.93
93_V 171_F 1.009 0.93
21_W 27_V 1.004 0.93
136_R 185_E 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9961000.006Contact Map0.88
2it1A20.94441000.013Contact Map0.875
2yyzA10.94441000.013Contact Map0.816
1v43A10.97621000.015Contact Map0.823
1g29120.96031000.016Contact Map0.9
1oxxK10.96031000.016Contact Map0.809
3fvqA20.96431000.021Contact Map0.784
3rlfA20.94441000.023Contact Map0.848
1z47A20.98021000.027Contact Map0.84
1b0uA10.97621000.03Contact Map0.792

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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