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CAS2 - CRISPR-associated endoribonuclease Cas2
UniProt: P45956 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12845
Length: 94 (94)
Sequences: 198
Seq/Len: 2.11

CAS2
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_E 49_G 1.968 0.99
34_D 67_G 1.669 0.96
18_R 46_Q 1.613 0.95
14_R 31_Y 1.608 0.95
32_V 59_A 1.606 0.95
7_V 57_V 1.597 0.95
31_Y 84_D 1.566 0.94
79_T 92_L 1.538 0.93
51_A 73_F 1.533 0.93
32_V 68_F 1.496 0.92
15_L 33_G 1.428 0.89
11_V 51_A 1.391 0.87
41_E 71_Q 1.388 0.87
1_M 61_A 1.387 0.87
48_A 73_F 1.384 0.87
39_I 68_F 1.375 0.86
6_V 19_L 1.325 0.84
86_L 94_V 1.314 0.83
22_W 33_G 1.306 0.82
69_E 87_R 1.303 0.82
26_V 47_I 1.292 0.81
14_R 78_R 1.29 0.81
67_G 72_T 1.29 0.81
21_I 66_T 1.284 0.81
26_V 70_F 1.273 0.80
83_L 94_V 1.252 0.79
4_L 26_V 1.241 0.78
39_I 83_L 1.24 0.78
21_I 43_I 1.219 0.76
7_V 30_V 1.202 0.74
48_A 53_E 1.199 0.74
22_W 54_G 1.198 0.74
18_R 21_I 1.192 0.74
10_N 28_A 1.155 0.70
69_E 82_D 1.148 0.70
45_E 71_Q 1.141 0.69
11_V 78_R 1.138 0.69
33_G 65_E 1.133 0.68
10_N 90_S 1.127 0.68
12_P 33_G 1.113 0.66
78_R 91_F 1.072 0.62
82_D 87_R 1.07 0.62
28_A 55_N 1.068 0.61
4_L 23_L 1.068 0.61
38_K 80_P 1.06 0.61
3_M 68_F 1.039 0.58
45_E 52_E 1.038 0.58
15_L 22_W 1.016 0.56
49_G 94_V 1.01 0.55
13_P 89_V 1.003 0.54
20_A 43_I 1.002 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4makA211000.024Contact Map0.413
4es1A10.925564.10.899Contact Map0.089
3oq2A20.925557.20.903Contact Map0.155
1zpwX10.88351.50.906Contact Map0.195
2ivyA10.936242.30.911Contact Map0.072
3excX10.88324.60.921Contact Map0.175
2i0xA10.851117.50.926Contact Map0.13
2r0bA10.723410.70.933Contact Map0
3zf7O10.3837.40.938Contact Map0
4av2A120.53196.20.94Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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