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AAEA - p-hydroxybenzoic acid efflux pump subunit AaeA
UniProt: P46482 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12823
Length: 310 (287)
Sequences: 5049
Seq/Len: 17.59

AAEA
Paralog alert: 0.76 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_K 162_D 4.549 1.00
60_Q 77_T 4.362 1.00
224_G 265_I 3.665 1.00
91_Q 149_K 3.577 1.00
87_L 145_R 3.512 1.00
74_I 156_V 3.459 1.00
70_K 73_Q 3.138 1.00
227_D 266_R 3.046 1.00
112_N 128_N 2.839 1.00
80_Q 84_Q 2.637 1.00
77_T 156_V 2.632 1.00
98_Q 142_Q 2.624 1.00
210_R 223_K 2.568 1.00
225_T 268_D 2.565 1.00
105_R 135_L 2.406 1.00
212_E 221_V 2.399 1.00
87_L 149_K 2.309 1.00
115_G 124_I 2.306 1.00
111_R 119_M 2.283 1.00
210_R 225_T 2.279 1.00
62_N 77_T 2.26 1.00
205_V 226_V 2.255 1.00
74_I 158_R 2.245 1.00
225_T 266_R 2.196 1.00
149_K 153_E 2.173 1.00
205_V 285_V 2.118 1.00
62_N 74_I 2.118 1.00
111_R 127_A 2.106 1.00
105_R 109_G 2.095 1.00
159_A 185_L 2.068 1.00
71_K 162_D 2.035 1.00
84_Q 152_L 2.019 1.00
67_Q 73_Q 2.01 1.00
94_V 145_R 1.94 1.00
88_E 91_Q 1.934 1.00
193_V 281_A 1.869 1.00
146_D 149_K 1.859 1.00
53_D 154_R 1.825 1.00
108_A 131_L 1.817 1.00
211_A 265_I 1.805 1.00
108_A 112_N 1.803 1.00
84_Q 88_E 1.786 1.00
91_Q 145_R 1.786 1.00
163_G 185_L 1.778 1.00
123_E 126_Q 1.774 1.00
76_F 157_I 1.764 1.00
68_L 188_Q 1.752 1.00
139_A 142_Q 1.75 1.00
131_L 135_L 1.736 1.00
87_L 91_Q 1.714 1.00
223_K 268_D 1.714 1.00
128_N 132_Q 1.714 1.00
105_R 131_L 1.711 1.00
212_E 223_K 1.687 1.00
83_Y 155_T 1.686 1.00
94_V 138_L 1.624 1.00
64_H 67_Q 1.618 1.00
108_A 128_N 1.611 1.00
197_M 205_V 1.594 1.00
89_E 144_T 1.58 1.00
68_L 164_W 1.577 1.00
115_G 121_R 1.544 1.00
132_Q 135_L 1.536 1.00
75_L 183_V 1.525 1.00
108_A 124_I 1.525 1.00
215_P 281_A 1.518 1.00
197_M 285_V 1.517 1.00
177_T 180_S 1.503 1.00
109_G 112_N 1.494 1.00
147_L 151_D 1.465 1.00
121_R 125_D 1.434 1.00
87_L 152_L 1.414 1.00
94_V 98_Q 1.414 1.00
103_E 107_E 1.393 0.99
150_L 154_R 1.393 0.99
56_G 78_I 1.391 0.99
198_E 201_K 1.382 0.99
44_S 194_L 1.367 0.99
226_V 263_V 1.36 0.99
261_V 279_T 1.352 0.99
214_T 284_V 1.351 0.99
102_Q 105_R 1.327 0.99
124_I 128_N 1.319 0.99
86_A 147_L 1.31 0.99
86_A 151_D 1.307 0.99
213_I 281_A 1.304 0.99
95_A 98_Q 1.302 0.99
90_A 141_A 1.295 0.99
107_E 126_Q 1.295 0.99
194_L 264_R 1.295 0.99
60_Q 172_T 1.286 0.99
195_A 283_V 1.279 0.99
110_R 125_D 1.274 0.99
69_V 75_L 1.271 0.99
59_T 77_T 1.259 0.99
87_L 148_A 1.246 0.98
111_R 122_E 1.241 0.98
165_V 183_V 1.227 0.98
61_V 172_T 1.212 0.98
101_A 131_L 1.189 0.98
145_R 149_K 1.189 0.98
88_E 146_D 1.184 0.98
76_F 182_A 1.18 0.98
228_S 264_R 1.179 0.98
106_Q 125_D 1.177 0.98
212_E 286_T 1.175 0.98
59_T 79_D 1.173 0.98
211_A 224_G 1.173 0.98
94_V 142_Q 1.171 0.98
43_F 193_V 1.167 0.97
195_A 265_I 1.165 0.97
58_I 170_V 1.159 0.97
142_Q 146_D 1.153 0.97
58_I 76_F 1.15 0.97
112_N 124_I 1.143 0.97
53_D 57_L 1.137 0.97
153_E 158_R 1.123 0.97
66_N 228_S 1.119 0.96
93_D 97_Y 1.113 0.96
176_I 182_A 1.113 0.96
197_M 263_V 1.105 0.96
50_I 183_V 1.102 0.96
213_I 267_L 1.1 0.96
52_P 176_I 1.1 0.96
159_A 162_D 1.095 0.96
25_I 29_W 1.088 0.96
109_G 113_R 1.059 0.95
26_F 30_V 1.055 0.95
92_A 143_A 1.052 0.95
47_V 184_A 1.048 0.94
214_T 221_V 1.045 0.94
59_T 62_N 1.037 0.94
86_A 148_A 1.033 0.94
41_A 45_A 1.031 0.94
102_Q 106_Q 1.016 0.93
74_I 77_T 1.01 0.93
213_I 283_V 1.008 0.93
90_A 93_D 1.006 0.93
48_V 161_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2f1mA40.83551000.392Contact Map0.728
3lnnA20.90321000.431Contact Map0.697
4dk0A10.93231000.434Contact Map0.617
3fppA20.8711000.438Contact Map0.744
1vf7A130.86131000.47Contact Map0.772
4l8jA10.83551000.472Contact Map0.751
3ne5B20.83551000.499Contact Map0.732
4kkuA40.64191000.582Contact Map0.781
2k32A10.367799.80.674Contact Map0.638
2dneA10.325899.60.747Contact Map0.649

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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