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COF - HMP-PP phosphatase
UniProt: P46891 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13216
Length: 272 (261)
Sequences: 5576
Seq/Len: 21.36

COF
Paralog alert: 0.74 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: COF MPGP SUPH YBHA YBJI YIDA YIGL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_P 250_R 4.67 1.00
247_G 256_H 4.056 1.00
209_A 223_V 3.348 1.00
248_H 251_N 3.324 1.00
220_L 226_G 3.177 1.00
23_K 259_T 2.873 1.00
3_R 206_D 2.85 1.00
15_M 19_H 2.791 1.00
197_T 207_C 2.761 1.00
23_K 252_Q 2.692 1.00
7_F 38_L 2.674 1.00
42_T 49_M 2.645 1.00
234_P 238_A 2.59 1.00
21_G 252_Q 2.488 1.00
217_R 236_L 2.458 1.00
6_A 193_L 2.314 1.00
188_N 218_E 2.237 1.00
247_G 251_N 2.231 1.00
30_R 33_E 2.201 1.00
228_I 240_L 2.122 1.00
22_E 26_S 2.121 1.00
236_L 239_E 2.089 1.00
217_R 239_E 2.058 1.00
25_L 55_A 2.051 1.00
204_L 222_S 2.045 1.00
221_V 239_E 2.041 1.00
194_T 222_S 2.024 1.00
30_R 259_T 2.013 1.00
4_L 39_T 2.008 1.00
203_S 206_D 2.008 1.00
214_M 235_Q 1.997 1.00
227_F 257_Y 1.948 1.00
234_P 237_R 1.894 1.00
226_G 241_P 1.885 1.00
195_V 198_Q 1.812 1.00
30_R 34_R 1.788 1.00
214_M 233_M 1.76 1.00
28_L 38_L 1.743 1.00
84_P 87_V 1.724 1.00
209_A 220_L 1.713 1.00
194_T 198_Q 1.677 1.00
9_M 14_L 1.676 1.00
191_A 194_T 1.655 1.00
6_A 41_A 1.638 1.00
63_I 192_A 1.607 1.00
7_F 210_F 1.555 1.00
2_A 208_M 1.549 1.00
230_G 248_H 1.544 1.00
228_I 232_A 1.524 1.00
5_A 258_L 1.504 1.00
225_S 241_P 1.46 1.00
190_G 222_S 1.455 1.00
205_R 224_G 1.448 1.00
254_V 258_L 1.444 1.00
31_L 36_I 1.409 1.00
246_I 253_A 1.407 0.99
21_G 24_T 1.407 0.99
26_S 30_R 1.398 0.99
223_V 226_G 1.395 0.99
242_H 261_W 1.388 0.99
197_T 204_L 1.378 0.99
225_S 242_H 1.375 0.99
79_H 195_V 1.375 0.99
134_D 137_K 1.365 0.99
37_T 200_L 1.354 0.99
5_A 31_L 1.342 0.99
90_L 169_R 1.331 0.99
193_L 219_M 1.329 0.99
246_I 257_Y 1.322 0.99
210_F 254_V 1.321 0.99
227_F 246_I 1.313 0.99
29_A 33_E 1.306 0.99
4_L 202_L 1.303 0.99
210_F 257_Y 1.301 0.99
15_M 250_R 1.288 0.99
197_T 202_L 1.285 0.99
27_T 255_S 1.273 0.99
220_L 236_L 1.268 0.99
24_T 252_Q 1.254 0.99
4_L 197_T 1.253 0.99
231_N 249_C 1.247 0.99
2_A 36_I 1.24 0.98
39_T 196_L 1.234 0.98
208_M 257_Y 1.231 0.98
72_S 76_E 1.229 0.98
217_R 221_V 1.222 0.98
42_T 64_T 1.22 0.98
235_Q 238_A 1.21 0.98
23_K 27_T 1.209 0.98
195_V 199_H 1.207 0.98
16_P 249_C 1.207 0.98
208_M 227_F 1.206 0.98
209_A 219_M 1.206 0.98
36_I 208_M 1.196 0.98
232_A 237_R 1.193 0.98
32_R 59_D 1.185 0.98
2_A 225_S 1.183 0.98
68_T 184_P 1.181 0.98
95_Q 148_F 1.18 0.98
2_A 206_D 1.173 0.98
173_C 183_L 1.165 0.97
204_L 207_C 1.163 0.97
184_P 187_C 1.163 0.97
87_V 90_L 1.161 0.97
159_Q 163_Y 1.154 0.97
242_H 246_I 1.138 0.97
23_K 256_H 1.137 0.97
232_A 236_L 1.132 0.97
208_M 261_W 1.124 0.97
228_I 236_L 1.109 0.96
242_H 257_Y 1.106 0.96
171_H 186_G 1.105 0.96
4_L 207_C 1.099 0.96
87_V 169_R 1.098 0.96
81_D 195_V 1.094 0.96
171_H 218_E 1.091 0.96
226_G 236_L 1.075 0.95
6_A 39_T 1.065 0.95
25_L 29_A 1.063 0.95
213_A 233_M 1.055 0.95
247_G 253_A 1.054 0.95
257_Y 261_W 1.044 0.94
6_A 207_C 1.04 0.94
5_A 36_I 1.038 0.94
96_W 113_G 1.034 0.94
188_N 191_A 1.032 0.94
190_G 218_E 1.016 0.93
87_V 170_A 1.008 0.93
68_T 187_C 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pgvA40.97061000.225Contact Map0.784
1nrwA10.94851000.262Contact Map0.807
2b30A40.96691000.269Contact Map0.769
3l7yA10.96691000.281Contact Map0.783
1nf2A30.97431000.284Contact Map0.856
3daoA20.95221000.286Contact Map0.761
1rkqA20.99261000.289Contact Map0.821
2rbkA10.93751000.293Contact Map0.75
1rlmA40.97791000.303Contact Map0.847
3dnpA10.98531000.305Contact Map0.811

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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