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AER - Aerotaxis receptor
UniProt: P50466 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12955
Length: 506 (506)
Sequences: 1191
Seq/Len: 2.35

AER
Paralog alert: 0.37 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: AER MCP1 MCP2 MCP3 MCP4
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
47_E 88_K 3.351 1.00
12_T 87_R 2.686 1.00
25_D 29_Y 2.513 1.00
9_Q 92_H 2.497 1.00
363_F 374_V 2.165 1.00
400_S 404_A 2.146 1.00
373_A 394_R 2.143 1.00
237_D 240_G 2.108 1.00
482_E 486_Q 2.097 1.00
53_H 70_W 2.002 0.99
41_S 93_Y 1.984 0.99
70_W 97_A 1.914 0.99
45_L 49_Q 1.904 0.99
330_G 435_I 1.855 0.99
394_R 399_R 1.813 0.98
235_R 240_G 1.81 0.98
79_W 83_V 1.751 0.98
309_N 453_T 1.737 0.98
363_F 391_G 1.715 0.97
85_N 93_Y 1.692 0.97
373_A 391_G 1.689 0.97
2_S 6_Y 1.649 0.96
221_K 226_E 1.618 0.96
247_G 250_G 1.616 0.96
395_H 398_S 1.561 0.95
4_H 7_V 1.557 0.95
66_F 85_N 1.552 0.95
57_R 85_N 1.547 0.94
53_H 97_A 1.546 0.94
295_T 466_A 1.541 0.94
363_F 400_S 1.531 0.94
38_V 41_S 1.527 0.94
462_S 465_R 1.523 0.94
348_T 357_L 1.514 0.94
53_H 66_F 1.506 0.93
35_D 39_Q 1.497 0.93
40_V 87_R 1.497 0.93
54_N 57_R 1.478 0.93
111_Y 115_R 1.473 0.92
115_R 118_A 1.455 0.92
344_I 421_G 1.453 0.92
51_Q 55_M 1.449 0.92
373_A 399_R 1.447 0.91
309_N 374_V 1.446 0.91
12_T 40_V 1.419 0.90
455_E 459_G 1.417 0.90
124_A 127_E 1.411 0.90
73_L 99_A 1.409 0.90
355_T 404_A 1.406 0.90
292_V 471_N 1.39 0.89
53_H 85_N 1.385 0.89
382_Q 399_R 1.374 0.88
341_M 344_I 1.364 0.88
70_W 85_N 1.362 0.88
103_V 108_I 1.36 0.88
425_V 428_A 1.355 0.87
403_A 449_I 1.343 0.87
54_N 93_Y 1.338 0.87
67_A 71_F 1.337 0.87
367_I 374_V 1.335 0.86
99_A 115_R 1.329 0.86
33_A 45_L 1.327 0.86
391_G 399_R 1.325 0.86
142_I 146_L 1.321 0.86
479_E 483_E 1.318 0.85
356_S 359_N 1.317 0.85
85_N 115_R 1.309 0.85
308_Q 311_A 1.308 0.85
20_L 36_T 1.296 0.84
391_G 394_R 1.284 0.83
66_F 70_W 1.283 0.83
318_K 322_T 1.282 0.83
374_V 391_G 1.275 0.83
374_V 404_A 1.275 0.83
273_T 483_E 1.273 0.83
37_F 53_H 1.273 0.83
219_A 245_A 1.271 0.83
52_P 69_M 1.269 0.82
479_E 482_E 1.268 0.82
85_N 99_A 1.267 0.82
2_S 5_P 1.266 0.82
8_T 91_D 1.261 0.82
30_I 48_L 1.26 0.82
42_G 88_K 1.258 0.82
33_A 49_Q 1.256 0.81
43_Y 56_V 1.255 0.81
66_F 99_A 1.251 0.81
285_T 481_V 1.249 0.81
43_Y 55_M 1.245 0.81
118_A 123_I 1.244 0.81
97_A 115_R 1.242 0.80
69_M 73_L 1.241 0.80
2_S 8_T 1.241 0.80
57_R 93_Y 1.239 0.80
325_N 329_Q 1.237 0.80
58_H 61_M 1.234 0.80
252_M 504_V 1.233 0.80
441_N 444_Q 1.23 0.80
120_D 123_I 1.229 0.80
79_W 115_R 1.228 0.79
16_D 117_R 1.227 0.79
76_G 108_I 1.226 0.79
344_I 404_A 1.224 0.79
2_S 7_V 1.224 0.79
20_L 33_A 1.221 0.79
83_V 113_S 1.22 0.79
24_T 85_N 1.213 0.78
61_M 65_A 1.211 0.78
340_T 367_I 1.208 0.78
384_K 395_H 1.207 0.78
58_H 84_K 1.204 0.78
337_V 340_T 1.203 0.77
296_V 467_V 1.203 0.77
85_N 95_V 1.203 0.77
341_M 410_L 1.2 0.77
24_T 57_R 1.197 0.77
329_Q 332_E 1.194 0.77
57_R 61_M 1.192 0.77
33_A 37_F 1.187 0.76
391_G 404_A 1.187 0.76
54_N 85_N 1.179 0.75
475_Q 486_Q 1.172 0.75
4_H 8_T 1.166 0.74
47_E 53_H 1.164 0.74
391_G 400_S 1.163 0.74
57_R 83_V 1.162 0.74
33_A 48_L 1.161 0.74
347_S 410_L 1.161 0.74
479_E 486_Q 1.16 0.74
302_M 330_G 1.159 0.74
43_Y 88_K 1.158 0.74
85_N 97_A 1.156 0.73
119_T 122_E 1.156 0.73
79_W 113_S 1.155 0.73
295_T 459_G 1.153 0.73
37_F 70_W 1.151 0.73
87_R 91_D 1.151 0.73
57_R 66_F 1.15 0.73
70_W 76_G 1.15 0.73
53_H 57_R 1.15 0.73
350_R 353_T 1.149 0.73
363_F 404_A 1.147 0.73
333_A 424_Q 1.145 0.72
374_V 460_L 1.142 0.72
309_N 367_I 1.14 0.72
66_F 95_V 1.139 0.72
374_V 471_N 1.138 0.72
43_Y 53_H 1.132 0.71
42_G 53_H 1.128 0.71
97_A 113_S 1.127 0.71
83_V 95_V 1.122 0.70
66_F 93_Y 1.121 0.70
33_A 56_V 1.118 0.70
10_Q 92_H 1.108 0.69
72_T 77_E 1.106 0.69
112_M 248_Q 1.106 0.69
93_Y 115_R 1.104 0.68
58_H 86_R 1.102 0.68
374_V 400_S 1.1 0.68
24_T 99_A 1.1 0.68
501_A 504_V 1.096 0.68
99_A 111_Y 1.096 0.68
94_W 126_V 1.095 0.68
493_H 496_S 1.092 0.67
6_Y 63_K 1.09 0.67
65_A 99_A 1.09 0.67
79_W 94_W 1.088 0.67
219_A 249_L 1.088 0.67
400_S 410_L 1.087 0.67
82_I 122_E 1.087 0.67
242_T 491_V 1.086 0.67
483_E 486_Q 1.086 0.67
423_Q 426_H 1.085 0.66
83_V 115_R 1.085 0.66
66_F 115_R 1.085 0.66
359_N 404_A 1.082 0.66
82_I 118_A 1.081 0.66
170_T 175_L 1.078 0.66
282_N 459_G 1.076 0.66
356_S 408_R 1.076 0.66
41_S 86_R 1.076 0.66
88_K 97_A 1.076 0.66
330_G 373_A 1.076 0.66
56_V 85_N 1.075 0.65
35_D 45_L 1.074 0.65
83_V 111_Y 1.073 0.65
459_G 466_A 1.072 0.65
354_I 411_I 1.072 0.65
222_V 249_L 1.072 0.65
57_R 115_R 1.071 0.65
341_M 421_G 1.069 0.65
291_N 459_G 1.068 0.65
338_I 429_G 1.067 0.65
382_Q 397_A 1.066 0.64
99_A 113_S 1.066 0.64
70_W 115_R 1.066 0.64
131_K 135_A 1.065 0.64
363_F 398_S 1.064 0.64
299_M 463_L 1.064 0.64
162_R 166_R 1.064 0.64
66_F 97_A 1.063 0.64
92_H 115_R 1.062 0.64
24_T 54_N 1.062 0.64
306_V 435_I 1.061 0.64
70_W 88_K 1.06 0.64
347_S 463_L 1.06 0.64
248_Q 252_M 1.06 0.64
418_V 421_G 1.059 0.64
359_N 401_A 1.059 0.64
316_A 442_V 1.058 0.64
354_I 357_L 1.057 0.64
363_F 367_I 1.055 0.63
40_V 93_Y 1.055 0.63
211_P 235_R 1.055 0.63
69_M 79_W 1.054 0.63
309_N 363_F 1.053 0.63
327_A 436_V 1.053 0.63
85_N 111_Y 1.052 0.63
28_S 37_F 1.052 0.63
315_A 416_D 1.051 0.63
57_R 97_A 1.051 0.63
301_Q 304_A 1.051 0.63
437_A 440_K 1.048 0.63
66_F 83_V 1.047 0.62
83_V 97_A 1.047 0.62
25_D 34_N 1.043 0.62
37_F 97_A 1.042 0.62
76_G 99_A 1.042 0.62
65_A 68_D 1.041 0.62
85_N 113_S 1.04 0.62
315_A 318_K 1.04 0.62
354_I 421_G 1.039 0.62
65_A 118_A 1.037 0.61
80_S 96_R 1.037 0.61
384_K 394_R 1.036 0.61
370_L 384_K 1.036 0.61
24_T 53_H 1.035 0.61
292_V 470_L 1.033 0.61
359_N 374_V 1.033 0.61
252_M 255_W 1.032 0.61
53_H 99_A 1.031 0.61
374_V 398_S 1.031 0.61
374_V 480_L 1.028 0.60
340_T 432_M 1.027 0.60
2_S 55_M 1.022 0.60
57_R 95_V 1.021 0.60
53_H 69_M 1.021 0.60
34_N 42_G 1.02 0.59
22_S 53_H 1.019 0.59
400_S 403_A 1.018 0.59
61_M 93_Y 1.018 0.59
369_A 393_V 1.015 0.59
22_S 85_N 1.014 0.59
357_L 403_A 1.012 0.59
337_V 403_A 1.011 0.58
219_A 222_V 1.011 0.58
78_P 98_N 1.01 0.58
369_A 373_A 1.01 0.58
70_W 83_V 1.01 0.58
433_E 437_A 1.009 0.58
79_W 85_N 1.008 0.58
69_M 85_N 1.007 0.58
413_A 417_K 1.006 0.58
37_F 57_R 1.006 0.58
302_M 459_G 1.005 0.58
53_H 88_K 1.004 0.58
235_R 238_E 1.002 0.57
34_N 48_L 1.002 0.57
62_P 65_A 1.002 0.57
31_T 56_V 1.001 0.57
65_A 83_V 1.001 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zx6A20.59681000.489Contact Map0.43
1qu7A20.44071000.579Contact Map0.372
2ch7A10.52771000.636Contact Map0.262
3g67A20.42091000.682Contact Map0.412
4i3mA10.33499.90.799Contact Map0.466
2gj3A20.235299.80.845Contact Map0.396
3lyxA20.243199.70.864Contact Map0.341
3ewkA10.231299.60.866Contact Map0.402
3volA10.399299.50.879Contact Map0.336
3f1pA10.227399.50.879Contact Map0.326

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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