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AEEP - L-Ala-D/L-Glu epimerase
UniProt: P51981 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13228
Length: 321 (318)
Sequences: 3786
Seq/Len: 11.91

AEEP
Paralog alert: 0.61 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: AEEP DGOD GUDD GUDX MENC RHMD RSPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
39_I 98_L 3.375 1.00
138_S 167_A 3.25 1.00
5_K 33_E 3.223 1.00
190_C 201_L 3.184 1.00
100_A 107_L 3.088 1.00
92_D 255_T 3.062 1.00
217_I 242_E 3.024 1.00
182_R 185_G 2.952 1.00
73_L 81_I 2.918 1.00
231_R 256_E 2.877 1.00
35_E 40_K 2.676 1.00
238_K 269_F 2.623 1.00
191_Q 194_A 2.617 1.00
209_D 212_A 2.6 1.00
118_T 318_E 2.6 1.00
39_I 102_R 2.489 1.00
251_T 260_L 2.449 1.00
134_A 167_A 2.416 1.00
138_S 142_Q 2.251 1.00
33_E 40_K 2.251 1.00
194_A 219_P 2.244 1.00
190_C 218_H 2.161 1.00
192_L 195_D 2.155 1.00
151_K 178_N 2.127 1.00
59_M 63_M 2.114 1.00
120_I 146_K 2.11 1.00
141_W 171_A 2.047 1.00
189_R 193_L 2.041 1.00
130_P 134_A 1.966 1.00
187_A 216_F 1.952 1.00
162_V 166_T 1.928 1.00
34_L 95_L 1.881 1.00
129_T 132_Q 1.873 1.00
205_L 216_F 1.856 1.00
183_A 216_F 1.744 1.00
92_D 96_W 1.736 1.00
223_C 245_N 1.729 1.00
162_V 196_L 1.728 1.00
262_T 265_R 1.722 1.00
194_A 220_L 1.72 1.00
10_A 26_E 1.708 1.00
39_I 101_R 1.706 1.00
158_S 192_L 1.7 1.00
168_V 173_L 1.665 1.00
162_V 195_D 1.644 1.00
174_I 199_A 1.635 1.00
33_E 42_T 1.618 1.00
18_V 23_S 1.617 1.00
45_C 90_A 1.599 1.00
248_L 257_A 1.581 1.00
105_Q 109_D 1.557 1.00
7_F 33_E 1.555 1.00
163_A 166_T 1.539 1.00
159_E 162_V 1.538 1.00
128_G 132_Q 1.532 1.00
175_V 198_V 1.531 1.00
148_L 171_A 1.529 1.00
246_I 257_A 1.525 1.00
156_L 159_E 1.519 1.00
60_A 64_S 1.515 1.00
172_T 199_A 1.513 1.00
256_E 259_A 1.489 1.00
37_E 102_R 1.478 1.00
230_T 233_N 1.473 1.00
187_A 215_N 1.47 1.00
97_D 101_R 1.467 1.00
139_T 142_Q 1.467 1.00
114_T 117_E 1.46 1.00
259_A 265_R 1.459 1.00
211_A 236_A 1.457 1.00
138_S 141_W 1.444 1.00
5_K 35_E 1.441 1.00
161_M 196_L 1.439 1.00
257_A 289_L 1.42 1.00
237_L 241_Y 1.416 1.00
134_A 166_T 1.41 1.00
96_W 255_T 1.406 0.99
238_K 263_E 1.395 0.99
141_W 148_L 1.39 0.99
315_T 320_H 1.375 0.99
135_N 138_S 1.366 0.99
73_L 77_E 1.362 0.99
247_K 274_G 1.359 0.99
238_K 267_Q 1.358 0.99
4_V 34_L 1.341 0.99
251_T 257_A 1.331 0.99
234_L 260_L 1.326 0.99
203_Q 245_N 1.325 0.99
183_A 215_N 1.323 0.99
158_S 162_V 1.319 0.99
132_Q 135_N 1.314 0.99
224_A 237_L 1.311 0.99
153_D 157_I 1.308 0.99
158_S 196_L 1.299 0.99
181_W 201_L 1.296 0.99
163_A 167_A 1.291 0.99
137_A 168_V 1.287 0.99
31_V 42_T 1.274 0.99
150_V 164_I 1.274 0.99
3_T 35_E 1.254 0.99
106_S 109_D 1.245 0.98
131_D 135_N 1.242 0.98
130_P 159_E 1.242 0.98
165_R 170_D 1.237 0.98
31_V 281_R 1.234 0.98
216_F 222_I 1.226 0.98
10_A 28_R 1.221 0.98
100_A 110_L 1.221 0.98
287_L 319_L 1.212 0.98
234_L 244_V 1.209 0.98
74_T 109_D 1.208 0.98
258_L 262_T 1.201 0.98
135_N 139_T 1.2 0.98
82_L 88_R 1.2 0.98
263_E 266_A 1.197 0.98
205_L 212_A 1.182 0.98
16_P 23_S 1.174 0.98
147_L 174_I 1.173 0.98
99_A 103_Q 1.162 0.97
139_T 143_A 1.161 0.97
161_M 193_L 1.161 0.97
194_A 218_H 1.16 0.97
233_N 236_A 1.16 0.97
134_A 168_V 1.154 0.97
134_A 138_S 1.15 0.97
136_S 139_T 1.148 0.97
165_R 173_L 1.145 0.97
107_L 254_L 1.14 0.97
314_F 319_L 1.136 0.97
177_A 201_L 1.129 0.97
158_S 195_D 1.128 0.97
214_E 240_R 1.122 0.97
204_P 222_I 1.12 0.96
8_E 28_R 1.116 0.96
108_A 288_P 1.102 0.96
57_S 60_A 1.1 0.96
93_C 285_A 1.095 0.96
161_M 175_V 1.091 0.96
225_D 247_K 1.089 0.96
177_A 181_W 1.088 0.96
223_C 243_M 1.086 0.96
229_H 233_N 1.082 0.96
76_E 102_R 1.082 0.96
63_M 66_V 1.072 0.95
191_Q 219_P 1.071 0.95
95_L 99_A 1.069 0.95
188_A 192_L 1.066 0.95
74_T 77_E 1.062 0.95
181_W 189_R 1.059 0.95
62_I 91_L 1.055 0.95
231_R 263_E 1.042 0.94
203_Q 225_D 1.04 0.94
205_L 213_L 1.03 0.94
228_C 233_N 1.027 0.94
213_L 224_A 1.026 0.94
41_G 94_A 1.022 0.93
164_I 168_V 1.022 0.93
235_K 263_E 1.012 0.93
198_V 220_L 1.012 0.93
159_E 163_A 1.011 0.93
140_L 143_A 1.006 0.93
183_A 205_L 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jpdX111000.075Contact Map0.726
4gfiA40.99381000.089Contact Map0.76
3s5sA20.99071000.13Contact Map0.67
3u9iA20.99071000.131Contact Map0.737
2pgeA10.99691000.132Contact Map0.654
3ijlA20.97821000.135Contact Map0.804
1wufA20.99381000.142Contact Map0.821
3qldA20.99381000.144Contact Map0.78
3i6eA811000.144Contact Map0.735
1wueA20.99381000.146Contact Map0.811

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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