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COBC - Alpha-ribazole phosphatase
UniProt: P52086 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13240
Length: 203 (197)
Sequences: 6644
Seq/Len: 33.73

COBC
Paralog alert: 0.82 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: COBC GPMA GPMB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
10_E 30_R 3.144 1.00
32_I 60_H 3.143 1.00
54_E 80_N 3.079 1.00
86_D 117_N 2.977 1.00
78_E 134_R 2.869 1.00
78_E 130_R 2.61 1.00
59_Q 75_I 2.392 1.00
2_R 180_A 2.329 1.00
129_E 159_R 2.306 1.00
36_Q 64_L 2.296 1.00
78_E 131_F 2.189 1.00
49_L 74_Q 2.175 1.00
26_P 56_E 2.137 1.00
128_V 152_V 2.118 1.00
148_S 152_V 2.057 1.00
26_P 60_H 2.052 1.00
32_I 64_L 2.051 1.00
10_E 28_T 2.033 1.00
60_H 63_R 2.032 1.00
6_I 38_L 2.032 1.00
50_V 62_A 1.997 1.00
2_R 143_N 1.99 1.00
90_R 98_E 1.989 1.00
6_I 65_V 1.956 1.00
50_V 66_L 1.954 1.00
119_E 127_R 1.943 1.00
6_I 145_L 1.867 1.00
79_L 131_F 1.819 1.00
48_D 142_Q 1.797 1.00
12_Q 28_T 1.778 1.00
29_A 32_I 1.778 1.00
2_R 182_D 1.777 1.00
120_G 123_A 1.758 1.00
4_W 47_F 1.728 1.00
12_Q 16_D 1.681 1.00
54_E 77_P 1.664 1.00
59_Q 63_R 1.646 1.00
32_I 36_Q 1.642 1.00
22_H 83_F 1.629 1.00
148_S 153_L 1.623 1.00
40_T 68_D 1.595 1.00
35_A 61_T 1.592 1.00
33_E 36_Q 1.584 1.00
22_H 80_N 1.561 1.00
47_F 145_L 1.531 1.00
33_E 37_N 1.477 1.00
51_L 131_F 1.454 1.00
48_D 143_N 1.445 1.00
65_V 147_V 1.442 1.00
153_L 173_V 1.438 1.00
4_W 143_N 1.431 1.00
190_L 193_L 1.421 1.00
91_H 94_D 1.418 1.00
52_C 75_I 1.401 0.99
13_A 18_L 1.393 0.99
123_A 126_Q 1.376 0.99
76_I 131_F 1.353 0.99
40_T 43_H 1.347 0.99
122_Q 126_Q 1.346 0.99
192_V 195_S 1.336 0.99
30_R 33_E 1.329 0.99
114_I 123_A 1.329 0.99
109_D 112_H 1.327 0.99
128_V 156_L 1.315 0.99
30_R 34_Q 1.313 0.99
37_N 40_T 1.309 0.99
49_L 142_Q 1.308 0.99
76_I 134_R 1.304 0.99
13_A 20_S 1.297 0.99
174_D 194_N 1.289 0.99
180_A 192_V 1.273 0.99
23_A 88_E 1.244 0.98
36_Q 67_S 1.239 0.98
28_T 31_G 1.238 0.98
10_E 15_I 1.237 0.98
182_D 191_R 1.235 0.98
129_E 133_A 1.226 0.98
83_F 88_E 1.205 0.98
29_A 33_E 1.184 0.98
90_R 94_D 1.164 0.97
14_N 175_Q 1.153 0.97
4_W 180_A 1.147 0.97
51_L 139_Q 1.142 0.97
51_L 74_Q 1.139 0.97
52_C 73_V 1.119 0.96
11_T 20_S 1.113 0.96
22_H 54_E 1.105 0.96
63_R 67_S 1.099 0.96
20_S 25_T 1.098 0.96
87_W 95_L 1.094 0.96
13_A 25_T 1.085 0.96
52_C 59_Q 1.066 0.95
124_F 152_V 1.061 0.95
131_F 146_V 1.051 0.94
36_Q 68_D 1.04 0.94
53_S 149_H 1.038 0.94
5_L 153_L 1.035 0.94
41_L 195_S 1.031 0.94
164_P 167_A 1.029 0.94
93_R 97_Q 1.025 0.93
52_C 58_A 1.019 0.93
47_F 143_N 1.019 0.93
39_H 64_L 1.015 0.93
11_T 175_Q 1.006 0.93
66_L 73_V 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ij5A211000.101Contact Map0.819
1h2eA111000.118Contact Map0.807
3gp3A411000.145Contact Map0.802
4embA411000.152Contact Map0.743
1e58A111000.152Contact Map0.735
3kkkA411000.155Contact Map0.84
3d8hA211000.16Contact Map0.792
4gpzA211000.162Contact Map0.804
3r7aA20.97041000.167Contact Map0.755
2hhjA211000.168Contact Map0.767

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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