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HISQ - Histidine transport system permease protein HisQ
UniProt: P52094 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12125
Length: 228 (214)
Sequences: 8024
Seq/Len: 37.50

HISQ
Paralog alert: 0.91 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
26_L 101_G 3.536 1.00
96_G 168_V 3.389 1.00
155_G 212_L 3.018 1.00
189_E 192_Y 2.892 1.00
133_T 136_Q 2.873 1.00
127_A 137_V 2.808 1.00
37_G 49_F 2.744 1.00
180_T 197_C 2.681 1.00
14_L 18_E 2.583 1.00
59_V 64_L 2.551 1.00
34_G 105_G 2.445 1.00
124_I 137_V 2.343 1.00
135_G 139_R 2.332 1.00
123_H 145_S 2.292 1.00
44_L 48_I 2.257 1.00
34_G 109_T 2.143 1.00
35_A 112_F 2.106 1.00
20_A 162_L 2.094 1.00
44_L 47_L 2.086 1.00
115_A 150_A 2.052 1.00
53_T 109_T 2.017 1.00
210_G 214_F 1.938 1.00
38_K 50_E 1.896 1.00
118_A 149_Y 1.88 1.00
202_L 206_T 1.834 1.00
91_D 94_V 1.792 1.00
13_A 204_F 1.763 1.00
10_L 14_L 1.746 1.00
124_I 128_T 1.723 1.00
20_A 165_T 1.722 1.00
178_K 182_L 1.721 1.00
22_S 97_I 1.71 1.00
18_E 93_M 1.704 1.00
15_V 18_E 1.698 1.00
128_T 137_V 1.696 1.00
30_I 105_G 1.692 1.00
214_F 217_R 1.677 1.00
108_F 154_I 1.668 1.00
68_I 99_T 1.645 1.00
184_G 190_P 1.614 1.00
206_T 210_G 1.598 1.00
39_L 116_F 1.532 1.00
24_V 158_W 1.511 1.00
19_L 168_V 1.509 1.00
133_T 137_V 1.506 1.00
59_V 103_I 1.491 1.00
210_G 213_L 1.462 1.00
11_Q 14_L 1.46 1.00
211_V 214_F 1.453 1.00
134_R 138_F 1.445 1.00
39_L 117_M 1.437 1.00
43_R 47_L 1.429 1.00
56_I 102_F 1.427 1.00
64_L 103_I 1.421 1.00
180_T 193_F 1.42 1.00
93_M 97_I 1.412 1.00
26_L 97_I 1.395 0.99
32_L 112_F 1.39 0.99
34_G 49_F 1.383 0.99
110_E 113_R 1.372 0.99
37_G 40_S 1.366 0.99
33_I 37_G 1.359 0.99
211_V 215_L 1.35 0.99
65_M 99_T 1.345 0.99
136_Q 140_R 1.342 0.99
132_F 136_Q 1.342 0.99
42_N 47_L 1.315 0.99
43_R 46_G 1.29 0.99
136_Q 139_R 1.266 0.99
214_F 218_R 1.25 0.99
168_V 175_D 1.241 0.98
184_G 194_A 1.22 0.98
15_V 173_L 1.185 0.98
18_E 22_S 1.181 0.98
112_F 150_A 1.18 0.98
128_T 134_R 1.178 0.98
31_G 108_F 1.166 0.97
37_G 45_S 1.163 0.97
22_S 101_G 1.162 0.97
29_I 33_I 1.155 0.97
108_F 157_N 1.146 0.97
27_A 104_Y 1.141 0.97
48_I 51_G 1.137 0.97
38_K 110_E 1.134 0.97
166_A 201_Y 1.119 0.96
174_E 178_K 1.103 0.96
162_L 208_S 1.102 0.96
218_R 221_V 1.1 0.96
119_V 149_Y 1.098 0.96
47_L 51_G 1.096 0.96
46_G 50_E 1.093 0.96
25_V 29_I 1.085 0.96
160_V 164_S 1.081 0.95
75_A 78_T 1.08 0.95
132_F 140_R 1.06 0.95
113_R 117_M 1.054 0.95
54_T 206_T 1.052 0.95
127_A 141_I 1.052 0.95
124_I 142_M 1.048 0.94
162_L 204_F 1.045 0.94
111_T 157_N 1.038 0.94
94_V 98_I 1.025 0.93
23_S 101_G 1.018 0.93
179_A 182_L 1.011 0.93
207_V 211_V 1.01 0.93
182_L 186_S 1.004 0.93
138_F 143_F 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.921199.90.622Contact Map0.778
2onkC40.969399.90.644Contact Map0.589
3rlfF10.969399.90.647Contact Map0.62
3d31C20.969399.90.652Contact Map0.54
3rlfG10.956199.80.681Contact Map0.5
3e7lA40.27635.70.963Contact Map0.594
2m8gX10.27193.60.966Contact Map0.473
4l5eA10.20182.50.969Contact Map0.519
1g2hA10.26752.50.969Contact Map0.384
1umqA10.31142.40.969Contact Map0.486

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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