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GLRK - Sensor histidine kinase GlrK
UniProt: P52101 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13461
Length: 475 (466)
Sequences: 1052
Seq/Len: 2.26

GLRK
Paralog alert: 0.52 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
445_I 466_I 2.986 1.00
402_I 463_C 2.489 1.00
456_D 459_G 2.302 1.00
441_A 452_L 2.279 1.00
379_Y 422_Q 2.224 1.00
456_D 462_V 2.164 1.00
210_R 215_R 2.161 1.00
326_E 329_P 2.15 1.00
227_S 230_R 2.128 1.00
457_E 460_Q 2.084 0.99
258_S 263_T 1.867 0.99
71_S 86_V 1.826 0.98
444_C 448_M 1.823 0.98
442_R 446_R 1.814 0.98
236_I 239_L 1.813 0.98
368_V 445_I 1.746 0.98
261_L 305_I 1.742 0.98
403_N 407_P 1.726 0.97
67_E 143_A 1.699 0.97
396_R 467_E 1.694 0.97
384_G 404_T 1.693 0.97
261_L 304_L 1.662 0.96
380_G 404_T 1.66 0.96
262_K 270_E 1.597 0.95
225_G 230_R 1.594 0.95
399_I 466_I 1.577 0.95
368_V 444_C 1.575 0.95
74_Q 86_V 1.547 0.94
350_D 387_C 1.544 0.94
454_L 464_F 1.53 0.94
255_R 367_S 1.529 0.94
256_H 262_K 1.528 0.94
389_R 400_D 1.524 0.93
102_A 115_R 1.516 0.93
387_C 404_T 1.504 0.93
416_I 464_F 1.5 0.93
71_S 74_Q 1.498 0.93
269_R 298_S 1.493 0.93
214_G 239_L 1.481 0.92
258_S 379_Y 1.48 0.92
327_L 399_I 1.472 0.92
67_E 70_R 1.463 0.92
283_L 287_Q 1.462 0.91
360_A 365_L 1.444 0.91
360_A 448_M 1.438 0.91
256_H 263_T 1.429 0.90
387_C 402_I 1.425 0.90
413_R 454_L 1.424 0.90
74_Q 83_L 1.421 0.90
262_K 302_Q 1.414 0.90
255_R 260_E 1.404 0.89
93_R 96_E 1.402 0.89
272_T 294_L 1.398 0.89
71_S 87_Y 1.395 0.89
260_E 263_T 1.37 0.88
368_V 448_M 1.37 0.88
323_E 362_P 1.37 0.88
456_D 460_Q 1.369 0.87
389_R 402_I 1.367 0.87
258_S 422_Q 1.366 0.87
249_Q 436_L 1.362 0.87
201_V 232_V 1.362 0.87
453_Y 466_I 1.362 0.87
348_H 385_N 1.358 0.87
247_E 250_R 1.351 0.87
247_E 260_E 1.351 0.87
373_Y 388_L 1.34 0.86
75_Y 84_A 1.33 0.85
67_E 86_V 1.327 0.85
255_R 315_Q 1.322 0.85
263_T 379_Y 1.32 0.85
254_L 263_T 1.318 0.85
258_S 262_K 1.316 0.85
247_E 263_T 1.309 0.84
69_E 73_R 1.308 0.84
253_F 378_H 1.296 0.83
407_P 461_D 1.296 0.83
247_E 266_A 1.29 0.83
204_I 229_L 1.282 0.82
253_F 379_Y 1.281 0.82
250_R 263_T 1.279 0.82
352_D 387_C 1.277 0.82
262_K 301_L 1.277 0.82
70_R 86_V 1.275 0.82
385_N 404_T 1.272 0.82
262_K 311_Y 1.272 0.82
264_P 371_N 1.269 0.81
251_H 424_S 1.269 0.81
71_S 78_L 1.264 0.81
136_A 140_E 1.261 0.81
371_N 420_F 1.261 0.81
208_I 239_L 1.258 0.81
50_T 185_V 1.255 0.80
264_P 433_G 1.252 0.80
266_A 441_A 1.246 0.80
342_A 349_T 1.238 0.79
380_G 422_Q 1.234 0.79
50_T 54_D 1.233 0.79
391_S 398_Y 1.233 0.79
256_H 270_E 1.232 0.79
255_R 262_K 1.232 0.79
11_L 14_L 1.224 0.78
258_S 371_N 1.222 0.78
265_L 304_L 1.221 0.78
400_D 463_C 1.216 0.78
71_S 90_Q 1.216 0.78
200_P 239_L 1.214 0.77
264_P 464_F 1.213 0.77
237_L 240_S 1.212 0.77
70_R 74_Q 1.209 0.77
253_F 258_S 1.207 0.77
262_K 267_S 1.206 0.77
260_E 367_S 1.204 0.77
220_S 237_L 1.198 0.76
267_S 307_Q 1.194 0.76
298_S 313_R 1.192 0.76
412_E 423_G 1.192 0.76
84_A 87_Y 1.191 0.75
258_S 378_H 1.19 0.75
371_N 464_F 1.187 0.75
267_S 301_L 1.183 0.75
256_H 419_P 1.182 0.75
403_N 461_D 1.178 0.74
417_F 420_F 1.173 0.74
258_S 374_S 1.172 0.74
263_T 436_L 1.168 0.73
350_D 385_N 1.168 0.73
263_T 422_Q 1.167 0.73
74_Q 78_L 1.167 0.73
331_V 351_V 1.154 0.72
67_E 90_Q 1.149 0.72
413_R 456_D 1.149 0.72
263_T 301_L 1.148 0.72
262_K 422_Q 1.147 0.71
253_F 374_S 1.147 0.71
251_H 379_Y 1.142 0.71
261_L 267_S 1.141 0.71
390_S 399_I 1.14 0.71
47_V 50_T 1.14 0.71
260_E 266_A 1.138 0.71
14_L 227_S 1.137 0.71
281_G 287_Q 1.137 0.71
262_K 308_L 1.136 0.70
71_S 84_A 1.134 0.70
246_L 270_E 1.131 0.70
269_R 302_Q 1.131 0.70
69_E 74_Q 1.131 0.70
254_L 260_E 1.13 0.70
255_R 316_A 1.13 0.70
259_H 263_T 1.128 0.70
250_R 260_E 1.127 0.70
298_S 302_Q 1.127 0.70
256_H 301_L 1.126 0.69
256_H 305_I 1.126 0.69
378_H 422_Q 1.121 0.69
410_Q 457_E 1.12 0.69
102_A 118_L 1.115 0.68
262_K 266_A 1.115 0.68
256_H 423_G 1.112 0.68
258_S 264_P 1.109 0.68
371_N 374_S 1.109 0.68
211_L 239_L 1.109 0.68
329_P 401_V 1.108 0.68
316_A 364_L 1.108 0.68
140_E 143_A 1.107 0.68
379_Y 433_G 1.103 0.67
368_V 441_A 1.103 0.67
393_H 398_Y 1.097 0.67
274_L 307_Q 1.096 0.66
78_L 83_L 1.093 0.66
260_E 301_L 1.092 0.66
70_R 73_R 1.089 0.66
380_G 384_G 1.088 0.66
74_Q 87_Y 1.088 0.66
388_L 462_V 1.087 0.66
263_T 380_G 1.086 0.65
417_F 433_G 1.086 0.65
284_T 287_Q 1.085 0.65
326_E 357_A 1.084 0.65
301_L 309_L 1.083 0.65
263_T 423_G 1.082 0.65
377_V 388_L 1.081 0.65
250_R 266_A 1.081 0.65
251_H 422_Q 1.078 0.65
263_T 315_Q 1.075 0.64
69_E 87_Y 1.073 0.64
255_R 266_A 1.072 0.64
408_I 462_V 1.07 0.64
259_H 372_L 1.064 0.63
259_H 264_P 1.064 0.63
259_H 371_N 1.062 0.63
257_L 262_K 1.062 0.63
311_Y 338_H 1.06 0.63
262_K 379_Y 1.058 0.62
445_I 448_M 1.058 0.62
254_L 364_L 1.057 0.62
69_E 117_D 1.057 0.62
263_T 267_S 1.055 0.62
256_H 311_Y 1.053 0.62
445_I 450_G 1.052 0.62
251_H 423_G 1.05 0.62
370_D 441_A 1.046 0.61
266_A 270_E 1.045 0.61
215_R 218_G 1.044 0.61
379_Y 424_S 1.044 0.61
254_L 301_L 1.043 0.61
453_Y 467_E 1.042 0.61
352_D 389_R 1.041 0.61
262_K 370_D 1.04 0.60
266_A 271_G 1.04 0.60
398_Y 467_E 1.039 0.60
263_T 364_L 1.038 0.60
50_T 110_L 1.037 0.60
238_W 402_I 1.036 0.60
74_Q 77_V 1.035 0.60
328_A 332_E 1.035 0.60
409_P 412_E 1.034 0.60
256_H 266_A 1.034 0.60
263_T 266_A 1.033 0.60
255_R 301_L 1.033 0.60
368_V 466_I 1.031 0.59
312_N 379_Y 1.026 0.59
23_L 175_F 1.025 0.59
261_L 265_L 1.024 0.59
358_C 397_V 1.023 0.59
256_H 271_G 1.023 0.59
256_H 337_A 1.02 0.58
75_Y 87_Y 1.02 0.58
61_M 94_Y 1.019 0.58
249_Q 261_L 1.019 0.58
15_V 19_F 1.018 0.58
255_R 258_S 1.018 0.58
264_P 444_C 1.017 0.58
254_L 315_Q 1.017 0.58
265_L 274_L 1.017 0.58
267_S 270_E 1.015 0.58
364_L 444_C 1.012 0.57
275_L 283_L 1.012 0.57
47_V 51_T 1.012 0.57
325_V 360_A 1.011 0.57
247_E 262_K 1.009 0.57
152_A 155_T 1.008 0.57
247_E 258_S 1.005 0.57
417_F 464_F 1.005 0.57
271_G 297_S 1.003 0.56
255_R 263_T 1.002 0.56
251_H 263_T 1.002 0.56
256_H 422_Q 1.002 0.56
459_G 462_V 1 0.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.65681000.456Contact Map0.452
4ew8A20.54111000.566Contact Map0.4
2btzA10.65471000.57Contact Map0.293
2c2aA10.51581000.576Contact Map0.367
4gczA20.71791000.58Contact Map0.363
3jz3A20.45891000.581Contact Map0.603
2q8gA10.67791000.582Contact Map0.294
2e0aA20.66321000.585Contact Map0.316
4e01A10.68841000.585Contact Map0.291
3d36A20.48211000.588Contact Map0.399

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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