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CSGD - CsgBAC operon transcriptional regulatory protein
UniProt: P52106 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13410
Length: 216 (203)
Sequences: 29865
Seq/Len: 147.12

CSGD
Paralog alert: 0.94 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_A 40_L 3.236 1.00
44_Q 64_D 2.7 1.00
16_I 46_S 2.483 1.00
23_A 42_N 2.48 1.00
65_K 74_T 2.423 1.00
159_R 162_E 2.412 1.00
93_Y 113_D 2.355 1.00
27_L 31_K 2.33 1.00
173_N 188_K 2.321 1.00
39_K 53_G 2.287 1.00
185_N 188_K 2.27 1.00
43_I 65_K 2.257 1.00
96_R 116_R 2.246 1.00
160_E 197_K 2.171 1.00
29_H 114_Q 2.107 1.00
47_L 74_T 2.092 1.00
12_T 37_T 2.015 1.00
66_K 69_H 1.977 1.00
165_N 169_I 1.945 1.00
27_L 40_L 1.866 1.00
12_T 39_K 1.846 1.00
142_H 150_S 1.838 1.00
30_L 121_L 1.804 1.00
190_H 193_N 1.802 1.00
72_Q 84_I 1.795 1.00
55_I 121_L 1.793 1.00
86_L 99_E 1.785 1.00
85_L 124_V 1.751 1.00
58_L 71_W 1.703 1.00
61_M 90_P 1.67 1.00
101_W 122_Q 1.655 1.00
166_K 179_S 1.651 1.00
60_M 86_L 1.636 1.00
166_K 176_I 1.627 1.00
58_L 72_Q 1.609 1.00
72_Q 86_L 1.6 1.00
172_S 175_E 1.592 1.00
74_T 77_R 1.578 1.00
105_N 127_G 1.574 1.00
17_T 23_A 1.529 1.00
65_K 69_H 1.503 1.00
200_V 209_W 1.501 1.00
86_L 104_I 1.501 1.00
171_A 179_S 1.482 1.00
56_I 82_I 1.48 1.00
90_P 95_Y 1.479 1.00
43_I 71_W 1.461 1.00
47_L 71_W 1.449 1.00
16_I 62_E 1.427 1.00
76_S 105_N 1.409 1.00
39_K 49_D 1.405 0.99
106_G 120_G 1.397 0.99
68_I 102_P 1.352 0.99
42_N 45_R 1.348 0.99
23_A 41_H 1.335 0.99
69_H 73_D 1.334 0.99
44_Q 65_K 1.312 0.99
60_M 68_I 1.308 0.99
74_T 78_K 1.299 0.99
41_H 49_D 1.288 0.99
166_K 171_A 1.281 0.99
44_Q 48_D 1.271 0.99
35_A 122_Q 1.269 0.99
47_L 65_K 1.266 0.99
92_D 95_Y 1.254 0.99
36_I 122_Q 1.249 0.99
50_I 75_L 1.228 0.98
73_D 98_I 1.228 0.98
14_L 41_H 1.216 0.98
157_T 197_K 1.211 0.98
46_S 50_I 1.2 0.98
34_L 118_V 1.199 0.98
189_T 192_Y 1.194 0.98
55_I 125_L 1.181 0.98
27_L 41_H 1.181 0.98
164_L 206_A 1.181 0.98
186_T 190_H 1.174 0.98
18_K 59_D 1.171 0.98
174_N 184_E 1.168 0.97
191_L 195_F 1.16 0.97
174_N 178_R 1.159 0.97
13_L 36_I 1.154 0.97
148_Y 162_E 1.15 0.97
209_W 213_N 1.146 0.97
94_P 98_I 1.144 0.97
171_A 175_E 1.121 0.97
162_E 165_N 1.105 0.96
20_S 42_N 1.102 0.96
26_L 87_L 1.1 0.96
45_R 49_D 1.098 0.96
14_L 46_S 1.098 0.96
39_K 51_S 1.097 0.96
124_V 127_G 1.079 0.95
145_N 165_N 1.077 0.95
61_M 89_T 1.077 0.95
17_T 62_E 1.074 0.95
68_I 98_I 1.073 0.95
97_D 115_E 1.072 0.95
16_I 56_I 1.069 0.95
45_R 48_D 1.067 0.95
49_D 53_G 1.059 0.95
62_E 71_W 1.052 0.95
123_G 128_E 1.049 0.94
161_K 165_N 1.043 0.94
175_E 179_S 1.041 0.94
14_L 53_G 1.038 0.94
26_L 117_V 1.023 0.93
15_L 38_G 1.02 0.93
93_Y 97_D 1.013 0.93
14_L 49_D 1.011 0.93
56_I 75_L 1.007 0.93
185_N 189_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c3wA20.95371000.118Contact Map0.59
4gvpA40.93981000.137Contact Map0.762
1a04A20.97221000.151Contact Map0.683
3kloA40.97691000.156Contact Map0.504
4hyeA20.94911000.158Contact Map0.802
1yioA10.92591000.192Contact Map0.698
4b09A120.98611000.197Contact Map0.652
1ys7A20.97691000.199Contact Map0.748
2gwrA10.95371000.224Contact Map0.645
3q9sA10.97221000.226Contact Map0.659

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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