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6PGL - 6-phosphogluconolactonase
UniProt: P52697 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13231
Length: 331 (319)
Sequences: 25225
Seq/Len: 79.08

6PGL
Paralog alert: 0.57 [within 20: 0.48] - ratio of genomes with paralogs
Cluster includes: 6PGL YNCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
81_P 98_V 2.826 1.00
60_V 98_V 2.657 1.00
86_H 99_G 2.614 1.00
40_P 53_G 2.565 1.00
151_I 192_C 2.549 1.00
180_H 193_V 2.454 1.00
131_S 145_A 2.449 1.00
51_Y 96_V 2.406 1.00
35_P 52_V 2.348 1.00
106_V 144_P 2.342 1.00
15_I 52_V 2.326 1.00
125_G 144_P 2.197 1.00
233_D 247_D 2.166 1.00
200_V 246_C 2.142 1.00
51_Y 89_T 2.132 1.00
51_Y 62_A 2.117 1.00
107_S 122_V 2.117 1.00
97_F 141_L 2.08 1.00
61_L 77_E 2.047 1.00
175_G 192_C 2.025 1.00
97_F 108_V 2.024 1.00
152_C 171_T 2.019 1.00
61_L 74_F 2.006 1.00
192_C 203_W 1.989 1.00
201_D 217_T 1.971 1.00
279_G 293_G 1.946 1.00
97_F 134_I 1.933 1.00
191_Y 243_L 1.873 1.00
88_S 133_N 1.87 1.00
191_Y 236_I 1.86 1.00
107_S 116_P 1.834 1.00
42_V 88_S 1.827 1.00
254_T 270_F 1.823 1.00
7_I 43_V 1.775 1.00
133_N 182_V 1.77 1.00
7_I 50_L 1.745 1.00
253_I 292_A 1.736 1.00
100_S 103_A 1.732 1.00
90_D 134_I 1.716 1.00
144_P 154_F 1.688 1.00
16_H 31_V 1.664 1.00
194_N 197_N 1.659 1.00
254_T 267_K 1.644 1.00
54_V 57_E 1.636 1.00
135_S 183_F 1.624 1.00
125_G 129_C 1.623 1.00
201_D 214_C 1.613 1.00
110_R 113_D 1.604 1.00
193_V 231_A 1.599 1.00
52_V 63_Y 1.58 1.00
235_H 281_N 1.568 1.00
98_V 109_T 1.556 1.00
225_F 246_C 1.545 1.00
143_V 190_A 1.535 1.00
235_H 280_F 1.534 1.00
130_H 147_K 1.529 1.00
100_S 105_N 1.523 1.00
182_V 235_H 1.491 1.00
191_Y 202_V 1.488 1.00
136_P 183_F 1.481 1.00
278_R 295_K 1.479 1.00
45_P 93_G 1.477 1.00
51_Y 87_I 1.463 1.00
85_T 102_N 1.462 1.00
145_A 178_P 1.453 1.00
175_G 194_N 1.433 1.00
16_H 28_L 1.433 1.00
64_R 69_D 1.425 1.00
143_V 183_F 1.422 1.00
53_G 84_P 1.42 1.00
191_Y 234_I 1.416 1.00
97_F 132_A 1.413 1.00
290_I 301_V 1.41 1.00
39_Q 56_P 1.4 0.99
182_V 234_I 1.398 0.99
155_T 158_D 1.396 0.99
237_T 282_V 1.396 0.99
194_N 199_S 1.382 0.99
283_D 287_K 1.378 0.99
8_A 18_W 1.375 0.99
247_D 277_P 1.372 0.99
184_H 236_I 1.363 0.99
193_V 234_I 1.357 0.99
99_G 129_C 1.355 0.99
80_L 109_T 1.333 0.99
91_H 138_N 1.331 0.99
44_S 48_R 1.33 0.99
204_E 209_H 1.316 0.99
146_L 150_R 1.314 0.99
28_L 31_V 1.311 0.99
267_K 270_F 1.309 0.99
125_G 146_L 1.308 0.99
256_F 267_K 1.306 0.99
88_S 132_A 1.301 0.99
152_C 162_L 1.297 0.99
214_C 217_T 1.295 0.99
54_V 59_R 1.295 0.99
81_P 103_A 1.29 0.99
245_A 289_L 1.286 0.99
53_G 87_I 1.283 0.99
74_F 77_E 1.278 0.99
81_P 100_S 1.277 0.99
44_S 89_T 1.275 0.99
238_P 286_G 1.273 0.99
179_R 196_L 1.256 0.99
125_G 148_Q 1.255 0.99
246_C 256_F 1.252 0.99
257_S 260_E 1.249 0.99
203_W 214_C 1.246 0.98
99_G 132_A 1.245 0.98
90_D 94_Q 1.243 0.98
133_N 181_M 1.234 0.98
7_I 17_V 1.23 0.98
175_G 197_N 1.22 0.98
143_V 181_M 1.218 0.98
185_P 236_I 1.218 0.98
135_S 139_R 1.213 0.98
185_P 240_G 1.201 0.98
136_P 187_E 1.199 0.98
91_H 134_I 1.198 0.98
248_R 252_L 1.195 0.98
7_I 41_M 1.186 0.98
49_Y 75_A 1.181 0.98
19_N 23_E 1.179 0.98
220_M 224_N 1.17 0.97
81_P 84_P 1.166 0.97
245_A 282_V 1.16 0.97
204_E 208_P 1.149 0.97
145_A 181_M 1.147 0.97
281_N 327_V 1.139 0.97
290_I 328_V 1.139 0.97
42_V 87_I 1.131 0.97
35_P 54_V 1.13 0.97
232_A 249_T 1.127 0.97
40_P 86_H 1.122 0.97
59_R 77_E 1.117 0.96
10_P 14_Q 1.11 0.96
233_D 279_G 1.11 0.96
64_R 75_A 1.108 0.96
9_S 38_V 1.105 0.96
184_H 188_Q 1.095 0.96
134_I 156_V 1.092 0.96
197_N 201_D 1.089 0.96
43_V 65_I 1.088 0.96
150_R 171_T 1.085 0.96
236_I 258_V 1.081 0.95
296_S 300_S 1.075 0.95
202_V 218_L 1.073 0.95
242_H 268_E 1.071 0.95
305_V 308_Q 1.07 0.95
294_Q 298_H 1.064 0.95
292_A 302_Y 1.063 0.95
183_F 205_L 1.061 0.95
250_A 254_T 1.06 0.95
220_M 256_F 1.058 0.95
255_V 271_Q 1.051 0.94
233_D 280_F 1.05 0.94
313_E 316_R 1.049 0.94
189_Y 215_V 1.044 0.94
81_P 107_S 1.033 0.94
253_I 280_F 1.029 0.94
247_D 280_F 1.028 0.94
300_S 316_R 1.024 0.93
86_H 131_S 1.019 0.93
174_E 203_W 1.019 0.93
103_A 107_S 1.019 0.93
40_P 87_I 1.012 0.93
95_F 117_V 1.007 0.93
89_T 282_V 1.006 0.93
54_V 61_L 1.004 0.93
89_T 111_L 1.002 0.92
182_V 236_I 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vyhC100.80971000.036Contact Map0.9
4jsnD20.89121000.067Contact Map0.785
3sfzA10.90631000.076Contact Map0.755
3ow8A40.81871000.079Contact Map0.878
4j0xA20.90331000.097Contact Map0.604
1gotB10.81271000.097Contact Map0.831
2ymuA20.8551000.106Contact Map0.938
4j87A10.83081000.11Contact Map0.814
3iz6a10.8551000.12Contact Map0.659
3dm0A10.82481000.127Contact Map0.863

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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