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ADIC - Arginine/agmatine antiporter
UniProt: P60061 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12462
Length: 445 (425)
Sequences: 10850
Seq/Len: 25.53

ADIC
Paralog alert: 0.82 [within 20: 0.39] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
313_I 325_A 4.211 1.00
137_V 331_G 3.561 1.00
316_R 325_A 3.212 1.00
305_A 315_A 3.2 1.00
169_G 245_A 3.185 1.00
11_G 218_K 3.091 1.00
374_L 378_G 3.062 1.00
222_R 226_I 3.056 1.00
50_I 236_A 2.921 1.00
366_L 395_F 2.814 1.00
219_N 222_R 2.746 1.00
254_A 268_M 2.463 1.00
328_I 332_I 2.443 1.00
308_G 312_P 2.418 1.00
16_T 230_G 2.381 1.00
217_V 223_N 2.35 1.00
12_L 230_G 2.345 1.00
313_I 316_R 2.336 1.00
302_K 306_D 2.315 1.00
167_V 171_F 2.294 1.00
369_C 394_A 2.278 1.00
90_N 304_A 2.271 1.00
318_N 324_V 2.216 1.00
273_T 277_I 2.211 1.00
59_V 369_C 2.155 1.00
74_Y 307_D 2.094 1.00
392_T 396_L 2.081 1.00
215_G 306_D 2.071 1.00
12_L 223_N 2.05 1.00
314_F 329_I 2.019 1.00
78_R 83_P 1.986 1.00
62_K 376_G 1.983 1.00
11_G 14_P 1.978 1.00
78_R 86_G 1.968 1.00
81_F 370_A 1.957 1.00
6_D 317_V 1.945 1.00
12_L 16_T 1.942 1.00
81_F 374_L 1.937 1.00
216_V 299_Q 1.926 1.00
137_V 327_L 1.923 1.00
15_V 217_V 1.912 1.00
51_I 55_G 1.894 1.00
141_I 324_V 1.873 1.00
145_K 149_R 1.862 1.00
226_I 230_G 1.856 1.00
130_V 338_Q 1.842 1.00
374_L 377_H 1.836 1.00
159_L 163_V 1.825 1.00
138_L 142_V 1.798 1.00
130_V 335_T 1.788 1.00
94_W 330_V 1.768 1.00
141_I 328_I 1.75 1.00
156_V 160_I 1.732 1.00
89_T 367_Y 1.686 1.00
229_I 233_L 1.676 1.00
77_A 89_T 1.674 1.00
14_P 152_A 1.673 1.00
251_P 254_A 1.662 1.00
134_W 335_T 1.661 1.00
45_G 196_T 1.659 1.00
219_N 226_I 1.655 1.00
47_L 240_V 1.625 1.00
10_V 14_P 1.608 1.00
233_L 237_V 1.595 1.00
16_T 234_I 1.576 1.00
220_P 225_P 1.551 1.00
276_A 280_F 1.539 1.00
264_D 267_R 1.538 1.00
318_N 322_T 1.536 1.00
133_L 334_M 1.53 1.00
325_A 329_I 1.52 1.00
312_P 315_A 1.506 1.00
297_A 330_V 1.499 1.00
160_I 164_G 1.495 1.00
301_A 326_G 1.487 1.00
82_G 85_L 1.486 1.00
389_A 393_I 1.484 1.00
129_C 338_Q 1.484 1.00
101_N 334_M 1.478 1.00
219_N 223_N 1.476 1.00
81_F 85_L 1.463 1.00
41_I 193_I 1.458 1.00
396_L 400_W 1.453 1.00
213_A 295_L 1.453 1.00
264_D 268_M 1.445 1.00
112_L 128_T 1.441 1.00
23_I 235_A 1.439 1.00
77_A 367_Y 1.436 1.00
140_N 291_G 1.436 1.00
298_G 327_L 1.425 1.00
12_L 226_I 1.41 1.00
105_V 133_L 1.406 0.99
166_A 241_L 1.402 0.99
91_V 420_I 1.398 0.99
169_G 249_M 1.394 0.99
267_R 275_G 1.39 0.99
57_S 232_V 1.389 0.99
320_A 324_V 1.387 0.99
134_W 331_G 1.367 0.99
422_A 426_L 1.364 0.99
56_L 369_C 1.359 0.99
20_S 234_I 1.358 0.99
136_F 290_L 1.358 0.99
332_I 336_I 1.35 0.99
173_F 248_G 1.35 0.99
67_D 79_R 1.342 0.99
137_V 328_I 1.336 0.99
105_V 290_L 1.336 0.99
370_A 395_F 1.335 0.99
142_V 320_A 1.332 0.99
126_T 130_V 1.329 0.99
10_V 148_T 1.324 0.99
80_C 371_A 1.322 0.99
223_N 226_I 1.311 0.99
312_P 316_R 1.31 0.99
64_S 76_Y 1.31 0.99
49_T 200_T 1.308 0.99
258_S 264_D 1.308 0.99
170_W 245_A 1.303 0.99
161_P 281_C 1.294 0.99
414_F 418_M 1.291 0.99
19_V 231_G 1.286 0.99
87_Y 91_V 1.282 0.99
370_A 374_L 1.282 0.99
267_R 272_D 1.281 0.99
59_V 391_T 1.271 0.99
395_F 399_I 1.27 0.99
301_A 310_F 1.268 0.99
137_V 141_I 1.268 0.99
130_V 134_W 1.263 0.99
70_P 215_G 1.261 0.99
271_G 274_A 1.26 0.99
366_L 370_A 1.253 0.99
51_I 393_I 1.243 0.98
57_S 228_T 1.242 0.98
43_I 244_T 1.241 0.98
411_M 415_V 1.241 0.98
52_G 397_Y 1.24 0.98
316_R 324_V 1.235 0.98
7_A 321_G 1.231 0.98
380_F 384_R 1.226 0.98
91_V 310_F 1.226 0.98
306_D 315_A 1.225 0.98
10_V 15_V 1.224 0.98
317_V 321_G 1.221 0.98
302_K 317_V 1.205 0.98
205_I 361_T 1.201 0.98
69_S 75_A 1.2 0.98
30_L 107_I 1.198 0.98
75_A 79_R 1.193 0.98
133_L 331_G 1.186 0.98
373_L 392_T 1.185 0.98
237_V 241_L 1.183 0.98
325_A 328_I 1.176 0.98
418_M 422_A 1.172 0.98
108_G 283_A 1.165 0.97
44_Y 193_I 1.165 0.97
144_P 295_L 1.164 0.97
13_I 149_R 1.164 0.97
150_V 154_A 1.162 0.97
270_L 274_A 1.158 0.97
249_M 265_A 1.156 0.97
415_V 419_V 1.155 0.97
386_A 390_V 1.153 0.97
379_H 382_K 1.146 0.97
159_L 238_C 1.144 0.97
13_I 17_L 1.138 0.97
388_L 392_T 1.137 0.97
127_I 131_V 1.131 0.97
422_A 425_A 1.129 0.97
141_I 322_T 1.123 0.97
138_L 141_I 1.122 0.97
77_A 85_L 1.119 0.96
77_A 371_A 1.111 0.96
50_I 204_F 1.107 0.96
106_V 341_S 1.103 0.96
130_V 339_L 1.097 0.96
112_L 283_A 1.093 0.96
415_V 418_M 1.091 0.96
14_P 149_R 1.089 0.96
9_K 145_K 1.084 0.96
55_G 393_I 1.083 0.96
84_F 421_T 1.079 0.95
218_K 223_N 1.074 0.95
62_K 65_F 1.074 0.95
74_Y 303_A 1.064 0.95
412_W 415_V 1.063 0.95
251_P 268_M 1.061 0.95
47_L 51_I 1.061 0.95
241_L 245_A 1.055 0.95
61_A 65_F 1.049 0.94
11_G 145_K 1.048 0.94
58_M 229_I 1.047 0.94
6_D 302_K 1.046 0.94
66_L 384_R 1.042 0.94
94_W 301_A 1.04 0.94
66_L 382_K 1.036 0.94
151_Q 291_G 1.036 0.94
19_V 210_A 1.036 0.94
318_N 321_G 1.035 0.94
15_V 227_A 1.033 0.94
71_G 74_Y 1.033 0.94
60_Y 73_S 1.031 0.94
18_M 213_A 1.026 0.94
139_L 150_V 1.025 0.93
96_A 361_T 1.021 0.93
170_W 174_R 1.015 0.93
208_E 212_V 1.015 0.93
63_M 372_L 1.013 0.93
74_Y 90_N 1.013 0.93
44_Y 47_L 1.011 0.93
236_A 240_V 1.008 0.93
171_F 176_E 1.002 0.92
214_A 224_V 1.002 0.92
389_A 392_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l1lA111000.264Contact Map0.687
3giaA10.96631000.339Contact Map0.586
4djkA20.97981000.353Contact Map0.607
2jlnA10.903498.80.869Contact Map0.415
3dh4A40.955198.20.888Contact Map0.402
2xq2A10.955197.80.899Contact Map0.491
4m48A10.959695.60.924Contact Map0.373
2a65A10.939394.30.93Contact Map0.432
2wswA10.804575.40.949Contact Map0.288
4ainA30.883164.50.952Contact Map0.376

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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