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HIS5 - Imidazole glycerol phosphate synthase subunit HisH
UniProt: P60595 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10450
Length: 196 (180)
Sequences: 8579
Seq/Len: 47.66

HIS5
Paralog alert: 0.89 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: HIS5 PABA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
104_P 148_P 3.24 1.00
83_L 172_F 3.087 1.00
4_V 30_S 2.991 1.00
84_G 147_M 2.862 1.00
102_D 148_P 2.776 1.00
2_N 26_E 2.697 1.00
134_E 185_A 2.344 1.00
152_W 167_V 2.157 1.00
20_I 43_F 2.141 1.00
153_T 163_F 2.083 1.00
32_D 35_V 2.079 1.00
188_K 191_K 2.066 1.00
80_M 174_G 2.021 1.00
191_K 195_E 1.996 1.00
152_W 169_K 1.979 1.00
84_G 166_A 1.977 1.00
5_I 17_K 1.957 1.00
37_L 68_A 1.89 1.00
23_H 191_K 1.889 1.00
22_R 187_A 1.833 1.00
2_N 28_K 1.813 1.00
168_Q 171_N 1.797 1.00
149_V 156_Q 1.762 1.00
66_I 82_L 1.758 1.00
154_I 167_V 1.728 1.00
120_R 136_G 1.707 1.00
51_Q 85_R 1.702 1.00
155_A 165_A 1.684 1.00
64_D 67_K 1.645 1.00
185_A 188_K 1.637 1.00
17_K 21_A 1.606 1.00
122_Y 156_Q 1.574 1.00
104_P 146_A 1.565 1.00
64_D 68_A 1.512 1.00
166_A 174_G 1.5 1.00
103_V 147_M 1.484 1.00
8_T 44_L 1.479 1.00
3_V 41_K 1.455 1.00
19_A 187_A 1.441 1.00
4_V 39_A 1.439 1.00
63_F 86_R 1.438 1.00
84_G 101_E 1.413 1.00
138_Y 184_A 1.407 0.99
124_Q 156_Q 1.406 0.99
80_M 147_M 1.401 0.99
127_N 167_V 1.378 0.99
137_A 185_A 1.372 0.99
70_T 170_D 1.352 0.99
153_T 156_Q 1.341 0.99
116_M 144_S 1.324 0.99
133_I 137_A 1.317 0.99
120_R 138_Y 1.312 0.99
74_L 175_V 1.303 0.99
28_K 39_A 1.272 0.99
65_L 68_A 1.271 0.99
157_C 165_A 1.27 0.99
44_L 62_L 1.269 0.99
43_F 74_L 1.253 0.99
151_P 169_K 1.247 0.99
121_V 139_F 1.241 0.98
125_A 152_W 1.24 0.98
5_I 43_F 1.238 0.98
58_R 63_F 1.234 0.98
18_S 21_A 1.232 0.98
119_N 140_Y 1.226 0.98
122_Y 136_G 1.223 0.98
147_M 166_A 1.218 0.98
25_Y 194_L 1.218 0.98
106_M 146_A 1.217 0.98
16_V 76_I 1.215 0.98
15_S 18_S 1.213 0.98
63_F 85_R 1.205 0.98
167_V 173_Y 1.199 0.98
41_K 193_F 1.197 0.98
129_L 173_Y 1.19 0.98
62_L 82_L 1.178 0.98
131_Q 195_E 1.155 0.97
83_L 174_G 1.154 0.97
51_Q 102_D 1.152 0.97
63_F 67_K 1.128 0.97
67_K 86_R 1.12 0.96
127_N 154_I 1.095 0.96
90_S 172_F 1.072 0.95
17_K 29_V 1.07 0.95
49_T 52_A 1.056 0.95
36_V 39_A 1.05 0.94
3_V 25_Y 1.044 0.94
23_H 190_L 1.033 0.94
42_L 69_C 1.019 0.93
102_D 149_V 1.015 0.93
5_I 20_I 1.015 0.93
132_G 192_N 1 0.92
85_R 102_D 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tqiA40.89291000.282Contact Map0.761
2ywbA40.88271000.286Contact Map0.772
1gpmA40.89291000.292Contact Map0.792
1jvnA20.98471000.292Contact Map0.621
2vxoA20.88781000.303Contact Map0.724
4gudA20.99491000.311Contact Map0.681
3uowA20.91841000.315Contact Map0.71
2lxnA10.87241000.338Contact Map0.64
2a9vA40.90311000.339Contact Map0.807
1gpwB30.9491000.345Contact Map0.665

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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