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AQPZ - Aquaporin Z
UniProt: P60844 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13270
Length: 231 (228)
Sequences: 2985
Seq/Len: 13.09

AQPZ
Paralog alert: 0.53 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: AQPZ GLPF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
9_C 94_V 4.103 1.00
67_T 81_V 3.722 1.00
139_L 218_I 3.634 1.00
71_W 78_A 3.52 1.00
13_F 98_L 3.435 1.00
139_L 214_V 3.303 1.00
9_C 90_V 3.057 1.00
135_L 211_V 3.018 1.00
71_W 81_V 2.971 1.00
5_L 87_A 2.897 1.00
13_F 95_A 2.846 1.00
5_L 83_G 2.769 1.00
148_V 169_A 2.747 1.00
135_L 139_L 2.672 1.00
72_A 217_I 2.665 1.00
143_A 219_G 2.572 1.00
141_L 177_S 2.536 1.00
44_G 171_T 2.504 1.00
4_K 80_E 2.43 1.00
191_T 195_I 2.305 1.00
85_V 213_I 2.172 1.00
184_S 190_S 2.152 1.00
68_I 213_I 2.112 1.00
54_V 62_F 2.039 1.00
213_I 217_I 1.928 1.00
48_L 167_G 1.926 1.00
19_G 43_F 1.862 1.00
174_H 183_T 1.845 1.00
174_H 178_I 1.824 1.00
141_L 185_V 1.818 1.00
11_G 62_F 1.809 1.00
61_H 84_Y 1.742 1.00
50_M 54_V 1.719 1.00
68_I 85_V 1.709 1.00
206_W 210_V 1.693 1.00
47_V 170_L 1.684 1.00
191_T 209_W 1.587 1.00
205_L 209_W 1.582 1.00
215_G 219_G 1.563 1.00
154_D 223_Y 1.514 1.00
97_A 196_F 1.483 1.00
143_A 222_I 1.479 1.00
170_L 185_V 1.478 1.00
93_I 192_A 1.473 1.00
66_V 149_I 1.469 1.00
173_I 185_V 1.464 1.00
146_L 216_G 1.446 1.00
17_F 98_L 1.421 1.00
87_A 91_G 1.42 1.00
134_A 181_T 1.41 1.00
76_F 81_V 1.401 0.99
78_A 81_V 1.394 0.99
67_T 88_Q 1.375 0.99
37_A 41_L 1.358 0.99
97_A 101_L 1.348 0.99
69_G 73_G 1.346 0.99
70_L 76_F 1.329 0.99
142_S 216_G 1.305 0.99
67_T 76_F 1.305 0.99
129_Y 201_A 1.299 0.99
18_G 46_T 1.279 0.99
138_E 181_T 1.278 0.99
137_V 180_V 1.256 0.99
190_S 194_A 1.251 0.99
74_G 224_R 1.247 0.99
25_L 180_V 1.243 0.98
54_V 60_G 1.225 0.98
143_A 218_I 1.224 0.98
93_I 196_F 1.224 0.98
92_G 96_A 1.224 0.98
96_A 193_V 1.223 0.98
143_A 147_L 1.221 0.98
102_I 137_V 1.219 0.98
23_A 39_V 1.203 0.98
109_F 121_Y 1.188 0.98
137_V 141_L 1.185 0.98
137_V 181_T 1.181 0.98
197_Q 200_W 1.173 0.98
51_A 163_P 1.161 0.97
98_L 140_V 1.153 0.97
135_L 207_F 1.153 0.97
14_W 144_G 1.146 0.97
139_L 215_G 1.144 0.97
89_V 209_W 1.139 0.97
7_A 57_I 1.135 0.97
2_F 5_L 1.13 0.97
48_L 164_I 1.114 0.96
164_I 168_L 1.113 0.96
15_L 47_V 1.108 0.96
89_V 191_T 1.106 0.96
13_F 94_V 1.104 0.96
50_M 62_F 1.099 0.96
53_A 148_V 1.097 0.96
71_W 76_F 1.086 0.96
20_C 99_L 1.086 0.96
211_V 215_G 1.082 0.96
78_A 82_V 1.076 0.95
132_L 136_V 1.076 0.95
139_L 211_V 1.067 0.95
92_G 192_A 1.064 0.95
16_V 20_C 1.061 0.95
23_A 27_A 1.059 0.95
135_L 210_V 1.056 0.95
145_F 170_L 1.053 0.95
191_T 205_L 1.045 0.94
94_V 97_A 1.023 0.93
162_A 166_I 1.013 0.93
32_L 36_F 1.01 0.93
21_G 99_L 1.01 0.93
104_S 110_D 1.01 0.93
41_L 171_T 1.009 0.93
131_M 207_F 1.008 0.93
51_A 66_V 1.002 0.92
85_V 89_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2o9gA111000.057Contact Map0.808
3llqA20.9871000.079Contact Map0.825
1ldfA10.99571000.119Contact Map0.804
3iyzA10.94811000.125Contact Map0.089
3c02A10.9741000.127Contact Map0.806
1j4nA10.95241000.133Contact Map0.783
2zz9A10.94811000.134Contact Map0.791
3cn5A10.96541000.14Contact Map0.808
2b6oA10.93511000.14Contact Map0.824
3gd8A10.93941000.142Contact Map0.835

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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