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LOLA - Outer-membrane lipoprotein carrier protein
UniProt: P61316 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12684
Length: 203 (189)
Sequences: 731
Seq/Len: 3.87

LOLA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
63_K 185_A 3.265 1.00
40_S 177_S 3.221 1.00
86_T 99_A 2.31 1.00
39_A 60_L 2.28 1.00
183_V 187_K 2.143 1.00
90_Y 196_V 1.959 1.00
152_V 158_I 1.888 1.00
38_H 179_Q 1.808 0.99
190_F 195_G 1.767 0.99
60_L 150_I 1.713 0.99
88_W 190_F 1.712 0.99
36_S 180_N 1.687 0.99
90_Y 190_F 1.644 0.99
61_W 183_V 1.642 0.99
61_W 187_K 1.64 0.99
95_E 196_V 1.528 0.98
83_D 189_T 1.524 0.98
69_N 79_I 1.523 0.98
15_V 19_V 1.478 0.97
184_D 187_K 1.474 0.97
91_N 94_V 1.463 0.97
161_F 175_L 1.46 0.97
63_K 67_L 1.452 0.97
71_H 79_I 1.432 0.96
37_F 62_V 1.399 0.96
57_Q 74_Q 1.394 0.95
14_L 133_D 1.385 0.95
64_R 175_L 1.349 0.94
59_D 170_R 1.319 0.93
40_S 73_T 1.313 0.93
164_V 170_R 1.302 0.93
80_L 89_F 1.288 0.92
192_P 198_V 1.285 0.92
59_D 71_H 1.281 0.92
38_H 61_W 1.278 0.92
22_D 25_S 1.241 0.90
88_W 97_A 1.237 0.90
37_F 60_L 1.219 0.89
113_L 150_I 1.211 0.89
96_Q 114_I 1.211 0.89
47_D 127_I 1.201 0.88
26_D 29_S 1.199 0.88
42_T 57_Q 1.198 0.88
18_S 21_A 1.197 0.88
148_F 163_A 1.194 0.88
128_K 135_V 1.192 0.88
64_R 109_T 1.181 0.87
82_S 102_L 1.172 0.87
25_S 29_S 1.162 0.86
109_T 113_L 1.159 0.86
78_S 93_F 1.158 0.86
50_G 110_P 1.156 0.86
135_V 147_Q 1.153 0.85
47_D 50_G 1.15 0.85
111_F 165_E 1.139 0.84
78_S 94_V 1.129 0.84
99_A 198_V 1.128 0.84
78_S 100_T 1.125 0.83
127_I 136_L 1.122 0.83
25_S 63_K 1.112 0.82
60_L 123_Q 1.112 0.82
165_E 169_Q 1.111 0.82
39_A 115_A 1.106 0.82
47_D 51_A 1.097 0.81
109_T 169_Q 1.096 0.81
37_F 178_Q 1.093 0.81
117_N 141_S 1.091 0.81
90_Y 97_A 1.08 0.80
131_G 177_S 1.074 0.79
31_L 37_F 1.074 0.79
96_Q 190_F 1.074 0.79
111_F 116_R 1.073 0.79
23_A 104_D 1.072 0.79
38_H 59_D 1.065 0.79
38_H 187_K 1.056 0.78
121_D 165_E 1.055 0.78
165_E 173_Y 1.055 0.78
88_W 99_A 1.047 0.77
39_A 96_Q 1.041 0.76
72_M 112_M 1.038 0.76
71_H 77_E 1.037 0.76
66_N 114_I 1.036 0.76
27_L 152_V 1.035 0.76
116_R 145_L 1.028 0.75
127_I 134_F 1.028 0.75
44_K 174_Q 1.024 0.75
74_Q 198_V 1.023 0.75
36_S 179_Q 1.016 0.74
192_P 195_G 1.013 0.74
141_S 196_V 1.012 0.73
160_Q 174_Q 1.011 0.73
110_P 113_L 1.004 0.73
70_W 163_A 1.003 0.73
16_A 19_V 1.001 0.72
80_L 124_Q 1 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1iwlA10.89661000.246Contact Map0.51
2w7qA20.96061000.284Contact Map0.585
4mxtA10.85711000.426Contact Map0.571
2yzyA10.891699.90.548Contact Map0.659
3buuA20.891699.90.593Contact Map0.595
3m4wA40.876899.50.697Contact Map0.445
3bk5A10.886799.50.701Contact Map0.554
3a24A20.615849.10.93Contact Map0.078
3mh9C20.8677.10.953Contact Map0.361
2jnaA20.41876.70.954Contact Map0.047

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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