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LOLB - Outer-membrane lipoprotein LolB
UniProt: P61320 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11293
Length: 207 (201)
Sequences: 369
Seq/Len: 1.84

LOLB
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
152_D 156_R 3.197 1.00
75_Q 81_Y 2.395 1.00
87_N 93_E 1.882 0.98
59_A 68_Y 1.698 0.95
59_A 198_K 1.663 0.95
83_L 135_L 1.649 0.94
87_N 92_T 1.614 0.94
59_A 189_E 1.579 0.93
175_G 186_A 1.556 0.92
81_Y 98_A 1.548 0.92
137_Q 145_D 1.527 0.91
65_Q 71_F 1.497 0.90
9_I 167_K 1.472 0.89
104_Q 114_T 1.466 0.88
57_A 198_K 1.455 0.88
143_P 176_Y 1.449 0.88
42_H 176_Y 1.446 0.87
39_W 143_P 1.436 0.87
63_D 66_K 1.434 0.87
140_L 197_I 1.434 0.87
21_A 66_K 1.409 0.86
57_A 86_T 1.404 0.85
7_R 34_P 1.401 0.85
54_T 71_F 1.399 0.85
75_Q 98_A 1.37 0.83
52_Y 71_F 1.365 0.83
70_R 202_D 1.333 0.81
7_R 168_N 1.327 0.81
83_L 96_L 1.317 0.80
162_Y 166_G 1.308 0.79
77_G 167_K 1.304 0.79
60_Y 128_M 1.299 0.79
80_R 99_Q 1.293 0.78
88_P 140_L 1.286 0.78
94_L 126_T 1.277 0.77
105_L 115_A 1.267 0.76
98_A 103_V 1.253 0.75
149_Y 157_L 1.248 0.75
111_Q 198_K 1.243 0.74
110_G 198_K 1.242 0.74
83_L 117_D 1.239 0.74
177_D 188_M 1.222 0.72
40_R 49_L 1.219 0.72
59_A 87_N 1.214 0.72
119_E 139_I 1.212 0.71
193_G 201_M 1.21 0.71
19_L 22_C 1.209 0.71
159_E 170_K 1.207 0.71
53_Q 173_Y 1.204 0.71
39_W 157_L 1.196 0.70
6_F 9_I 1.192 0.70
62_S 118_A 1.188 0.69
126_T 130_I 1.187 0.69
158_S 201_M 1.187 0.69
119_E 133_N 1.183 0.69
83_L 87_N 1.178 0.68
57_A 63_D 1.173 0.68
119_E 128_M 1.173 0.68
100_P 105_L 1.172 0.68
130_I 205_I 1.171 0.68
75_Q 128_M 1.163 0.67
102_N 114_T 1.16 0.67
10_R 13_P 1.157 0.66
71_F 149_Y 1.138 0.64
59_A 202_D 1.135 0.64
115_A 121_M 1.132 0.64
52_Y 65_Q 1.13 0.64
199_L 202_D 1.129 0.64
52_Y 60_Y 1.126 0.63
63_D 88_P 1.12 0.63
89_L 92_T 1.118 0.62
7_R 31_G 1.116 0.62
98_A 118_A 1.11 0.62
74_Q 80_R 1.107 0.61
118_A 175_G 1.103 0.61
87_N 113_Y 1.1 0.61
11_L 14_L 1.097 0.60
85_L 126_T 1.087 0.59
52_Y 75_Q 1.086 0.59
61_I 198_K 1.084 0.59
93_E 157_L 1.083 0.59
6_F 77_G 1.076 0.58
83_L 94_L 1.064 0.57
37_P 46_V 1.057 0.56
179_K 182_P 1.055 0.56
54_T 139_I 1.055 0.56
53_Q 146_A 1.055 0.56
64_Q 172_V 1.051 0.55
107_D 111_Q 1.032 0.53
81_Y 132_L 1.031 0.53
75_Q 79_D 1.028 0.53
107_D 125_L 1.027 0.53
52_Y 139_I 1.02 0.52
81_Y 128_M 1.019 0.52
77_G 174_G 1.019 0.52
77_G 168_N 1.013 0.51
59_A 126_T 1.005 0.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1iwmA20.89861000.213Contact Map0.379
3zbiC140.231983.50.92Contact Map0
1fftB20.772939.70.941Contact Map0.014
4jg9A20.782629.90.945Contact Map0.026
4gb7A10.946915.10.952Contact Map0.07
3buuA20.859911.70.955Contact Map0.158
4fajA10.85519.80.956Contact Map0.044
4av2M120.60395.40.961Contact Map0.243
1iwlA10.7155.40.961Contact Map0.251
2hyxA40.85513.20.965Contact Map0.231

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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