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CAN - Carbonic anhydrase 2
UniProt: P61517 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12319
Length: 220 (203)
Sequences: 1824
Seq/Len: 8.99

CAN
Paralog alert: 0.45 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: CAN CYNT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
151_V 178_G 4.295 1.00
159_G 168_W 3.802 1.00
36_R 91_E 3.786 1.00
67_A 103_G 2.906 1.00
5_D 9_S 2.889 1.00
155_V 178_G 2.831 1.00
170_R 173_K 2.692 1.00
82_Q 86_D 2.357 1.00
66_V 80_V 2.343 1.00
92_H 177_H 2.308 1.00
165_Q 169_K 2.304 1.00
33_Q 45_S 2.259 1.00
38_L 81_V 2.18 1.00
155_V 176_I 2.147 1.00
147_C 180_A 2.105 1.00
166_S 170_R 2.034 1.00
84_A 90_V 1.9 1.00
99_Y 180_A 1.897 1.00
12_A 187_L 1.821 1.00
85_V 167_A 1.796 1.00
91_E 173_K 1.788 1.00
89_E 167_A 1.783 1.00
8_I 190_D 1.746 1.00
78_L 161_S 1.723 1.00
13_L 54_G 1.609 1.00
9_S 13_L 1.579 1.00
12_A 16_K 1.568 1.00
167_A 173_K 1.554 1.00
83_Y 102_G 1.487 1.00
182_G 185_D 1.477 1.00
53_T 60_L 1.466 1.00
94_I 179_W 1.453 1.00
39_W 96_C 1.435 0.99
68_N 150_N 1.428 0.99
63_H 80_V 1.419 0.99
179_W 188_L 1.408 0.99
182_G 189_R 1.407 0.99
105_Q 109_E 1.405 0.99
43_S 61_F 1.4 0.99
148_E 189_R 1.385 0.99
164_M 174_V 1.369 0.99
108_V 146_L 1.364 0.99
151_V 155_V 1.354 0.99
143_L 147_C 1.342 0.99
81_V 158_L 1.329 0.99
38_L 90_V 1.293 0.99
133_L 145_T 1.28 0.98
105_Q 143_L 1.279 0.98
32_A 100_G 1.277 0.98
27_E 30_A 1.263 0.98
17_M 21_E 1.263 0.98
10_N 14_W 1.258 0.98
159_G 176_I 1.245 0.98
92_H 175_T 1.244 0.98
43_S 88_L 1.239 0.98
192_D 199_E 1.23 0.98
38_L 93_I 1.22 0.98
43_S 63_H 1.217 0.98
157_N 160_H 1.217 0.98
167_A 174_V 1.205 0.98
53_T 96_C 1.198 0.97
38_L 80_V 1.181 0.97
100_G 184_H 1.18 0.97
148_E 180_A 1.179 0.97
39_W 53_T 1.167 0.97
83_Y 87_V 1.131 0.96
47_V 62_V 1.118 0.96
85_V 90_V 1.115 0.96
62_V 65_N 1.105 0.95
99_Y 182_G 1.105 0.95
65_N 68_N 1.099 0.95
55_L 59_E 1.083 0.95
96_C 179_W 1.081 0.94
151_V 180_A 1.078 0.94
104_V 123_I 1.076 0.94
102_G 116_I 1.071 0.94
41_G 47_V 1.06 0.94
66_V 103_G 1.058 0.94
126_I 153_E 1.056 0.94
34_K 89_E 1.054 0.93
13_L 17_M 1.054 0.93
149_L 152_M 1.052 0.93
85_V 164_M 1.04 0.93
198_R 203_Q 1.038 0.93
87_V 116_I 1.033 0.93
33_Q 102_G 1.032 0.93
25_F 28_K 1.031 0.92
179_W 190_D 1.031 0.92
134_L 137_M 1.03 0.92
97_G 151_V 1.029 0.92
158_L 176_I 1.002 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qy1A211000.161Contact Map0.765
1ddzA211000.167Contact Map0.62
3e3iA120.99551000.174Contact Map0.72
3ucjA20.96821000.194Contact Map0.74
2w3qA10.90911000.202Contact Map0.649
1ekjA80.91821000.221Contact Map0.759
3eyxA20.91000.23Contact Map0.751
1ym3A10.87271000.253Contact Map0.585
3vqjA10.87731000.272Contact Map0.548
3lasA20.74091000.347Contact Map0.7

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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