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APAG - Protein ApaG
UniProt: P62672 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10047
Length: 125 (122)
Sequences: 607
Seq/Len: 4.98

APAG
Paralog alert: 0.04 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
47_G 100_E 2.826 1.00
34_T 81_Q 2.173 1.00
96_Q 115_V 2.126 1.00
49_Y 61_E 2.073 1.00
92_L 119_A 1.931 1.00
8_C 38_L 1.929 1.00
52_I 62_V 1.926 1.00
4_S 125_H 1.897 1.00
10_Q 36_R 1.895 1.00
44_Q 73_L 1.843 1.00
98_H 110_S 1.716 1.00
99_Y 113_I 1.691 0.99
103_D 107_V 1.678 0.99
49_Y 63_Q 1.674 0.99
36_R 79_E 1.622 0.99
73_L 104_E 1.598 0.99
32_T 83_T 1.597 0.99
75_A 78_E 1.554 0.99
21_S 24_N 1.521 0.99
29_F 92_L 1.461 0.98
19_Q 85_G 1.43 0.98
100_E 110_S 1.43 0.98
54_N 88_I 1.41 0.97
74_I 78_E 1.378 0.97
15_Y 22_P 1.376 0.97
7_V 43_V 1.373 0.97
25_E 33_V 1.347 0.96
4_S 124_I 1.345 0.96
28_V 87_I 1.344 0.96
92_L 117_R 1.344 0.96
35_I 78_E 1.317 0.96
43_V 125_H 1.311 0.96
29_F 117_R 1.294 0.95
94_T 115_V 1.224 0.93
45_L 101_M 1.222 0.93
46_L 65_E 1.213 0.93
66_G 99_Y 1.211 0.93
13_S 87_I 1.2 0.92
49_Y 98_H 1.191 0.92
11_V 33_V 1.174 0.91
7_V 101_M 1.156 0.90
42_P 74_I 1.144 0.90
10_Q 34_T 1.123 0.88
64_G 95_M 1.121 0.88
53_T 119_A 1.114 0.88
53_T 90_T 1.098 0.87
44_Q 71_Q 1.085 0.86
74_I 80_Y 1.075 0.85
9_I 103_D 1.073 0.85
29_F 94_T 1.06 0.84
75_A 104_E 1.059 0.84
14_V 81_Q 1.049 0.83
29_F 119_A 1.045 0.83
43_V 101_M 1.042 0.83
29_F 114_P 1.037 0.82
12_Q 34_T 1.035 0.82
94_T 120_V 1.034 0.82
13_S 92_L 1.033 0.82
44_Q 102_I 1.031 0.82
42_P 73_L 1.028 0.82
100_E 108_P 1.023 0.81
60_T 89_E 1.018 0.81
63_Q 98_H 1.016 0.80
8_C 36_R 1.011 0.80
41_A 105_N 1.004 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xvsA211000.04Contact Map0.688
2f1eA111000.042Contact Map0.531
1tzaA211000.046Contact Map0.644
1xq4A40.9921000.056Contact Map0.601
3nrfA20.84867.70.916Contact Map0.334
3cfuA20.8835.70.931Contact Map0.397
1cuoA10.78431.20.933Contact Map0.343
2iaaC10.76828.30.934Contact Map0.34
2ccwA10.77626.90.935Contact Map0.314
3ay2A20.78421.60.938Contact Map0.318

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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