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CLPB - Chaperone protein ClpB
UniProt: P63284 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10157
Length: 857 (856)
Sequences: 3435
Seq/Len: 4.01

CLPB
Paralog alert: 0.82 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CLPA CLPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
796_S 847_E 5.767 1.00
170_E 174_Q 5.31 1.00
167_D 236_R 5.133 1.00
776_Q 800_L 5.053 1.00
346_T 374_A 4.887 1.00
165_T 238_L 4.283 1.00
772_A 801_K 4.201 1.00
832_Q 837_E 3.773 1.00
343_V 374_A 3.652 1.00
768_E 805_E 3.626 1.00
798_E 847_E 3.495 1.00
565_E 568_H 3.301 1.00
193_V 336_V 3.082 1.00
267_A 307_E 3.078 1.00
698_R 706_T 2.975 1.00
567_H 574_N 2.965 1.00
561_R 564_Q 2.955 1.00
412_L 455_Y 2.935 1.00
419_I 448_L 2.922 1.00
243_G 298_M 2.92 1.00
716_M 757_I 2.849 1.00
600_S 694_L 2.787 1.00
825_I 846_L 2.765 1.00
562_M 621_F 2.717 1.00
490_R 502_Q 2.703 1.00
796_S 845_R 2.576 1.00
347_I 370_I 2.517 1.00
166_I 171_R 2.51 1.00
508_E 512_Q 2.497 1.00
582_N 831_Q 2.431 1.00
779_L 795_I 2.419 1.00
563_E 578_D 2.415 1.00
423_K 452_E 2.385 1.00
190_T 336_V 2.377 1.00
720_L 745_V 2.34 1.00
780_K 783_Y 2.332 1.00
342_S 345_D 2.329 1.00
799_A 853_I 2.308 1.00
615_C 715_I 2.297 1.00
582_N 827_N 2.262 1.00
532_T 535_E 2.235 1.00
802_L 848_V 2.208 1.00
693_V 714_V 2.201 1.00
250_K 254_E 2.197 1.00
602_L 757_I 2.194 1.00
720_L 748_N 2.184 1.00
479_L 506_I 2.175 1.00
426_Q 445_N 2.141 1.00
745_V 754_I 2.136 1.00
365_I 398_A 2.125 1.00
829_L 844_I 2.121 1.00
26_N 68_L 2.106 1.00
50_L 55_I 2.098 1.00
571_I 777_I 2.091 1.00
242_M 245_L 2.075 1.00
343_V 378_H 2.073 1.00
167_D 170_E 2.068 1.00
264_N 268_K 2.062 1.00
630_V 672_S 2.059 1.00
203_V 280_L 2.037 1.00
767_G 770_H 2.022 1.00
641_H 650_P 2.02 1.00
553_E 561_R 2.019 1.00
63_D 128_A 1.993 1.00
496_A 500_E 1.992 1.00
159_Q 162_K 1.99 1.00
563_E 585_R 1.989 1.00
569_R 617_A 1.988 1.00
577_V 614_L 1.988 1.00
838_L 844_I 1.982 1.00
230_E 233_K 1.965 1.00
768_E 801_K 1.955 1.00
90_V 114_A 1.943 1.00
640_K 685_D 1.927 1.00
802_L 853_I 1.923 1.00
497_R 500_E 1.91 1.00
488_Q 492_V 1.9 1.00
725_I 737_M 1.9 1.00
803_L 820_A 1.898 1.00
321_Q 658_E 1.882 1.00
778_Q 818_K 1.876 1.00
245_L 262_V 1.862 1.00
264_N 267_A 1.861 1.00
226_G 233_K 1.85 1.00
806_N 824_Q 1.849 1.00
207_E 316_L 1.848 1.00
602_L 679_V 1.84 1.00
771_I 804_S 1.839 1.00
280_L 323_I 1.835 1.00
847_E 854_V 1.834 1.00
372_A 533_D 1.823 1.00
693_V 699_L 1.818 1.00
794_H 845_R 1.816 1.00
775_A 804_S 1.809 1.00
36_S 65_N 1.808 1.00
393_L 540_L 1.799 1.00
178_D 197_R 1.793 0.99
666_V 712_T 1.776 0.99
569_R 613_E 1.767 0.99
782_L 821_I 1.765 0.99
641_H 644_S 1.757 0.99
505_K 508_E 1.743 0.99
594_P 785_R 1.74 0.99
446_E 450_D 1.737 0.99
789_R 840_P 1.736 0.99
401_I 531_V 1.731 0.99
482_A 506_I 1.73 0.99
799_A 848_V 1.715 0.99
603_F 715_I 1.714 0.99
10_F 111_F 1.708 0.99
638_M 642_S 1.698 0.99
604_L 718_S 1.695 0.99
353_L 356_R 1.688 0.99
567_H 577_V 1.683 0.99
189_R 396_E 1.672 0.99
339_A 669_R 1.671 0.99
569_R 620_N 1.669 0.99
772_A 797_D 1.653 0.99
778_Q 781_R 1.648 0.99
794_H 843_V 1.644 0.99
373_A 394_I 1.638 0.99
63_D 66_Q 1.634 0.99
222_R 227_E 1.633 0.99
479_L 513_L 1.624 0.99
795_I 799_A 1.62 0.99
579_A 761_V 1.611 0.99
475_I 513_L 1.609 0.99
602_L 745_V 1.607 0.99
820_A 824_Q 1.604 0.99
565_E 621_F 1.591 0.98
628_A 669_R 1.588 0.98
90_V 115_A 1.572 0.98
486_I 506_I 1.566 0.98
734_Y 737_M 1.561 0.98
337_F 669_R 1.557 0.98
35_M 122_L 1.554 0.98
839_V 842_K 1.546 0.98
427_Q 430_M 1.545 0.98
34_L 87_L 1.545 0.98
343_V 375_T 1.54 0.98
471_G 512_Q 1.538 0.98
575_E 764_H 1.531 0.98
500_E 505_K 1.531 0.98
348_A 351_R 1.526 0.98
585_R 831_Q 1.516 0.98
792_E 843_V 1.516 0.98
375_T 788_E 1.514 0.98
371_V 375_T 1.512 0.98
177_L 221_Q 1.508 0.98
418_R 447_E 1.508 0.98
162_K 170_E 1.508 0.98
171_R 176_K 1.491 0.97
449_S 453_R 1.489 0.97
561_R 565_E 1.485 0.97
742_L 745_V 1.481 0.97
478_E 512_Q 1.475 0.97
477_A 481_Q 1.466 0.97
364_Q 530_K 1.462 0.97
277_I 310_C 1.461 0.97
666_V 709_F 1.459 0.97
55_I 60_L 1.456 0.97
27_Q 74_V 1.448 0.97
779_L 821_I 1.445 0.97
791_Y 838_L 1.444 0.97
418_R 421_Q 1.439 0.97
587_S 592_A 1.432 0.97
83_P 87_L 1.429 0.96
566_L 570_V 1.427 0.96
828_P 855_A 1.421 0.96
434_D 437_S 1.42 0.96
630_V 666_V 1.418 0.96
644_S 647_V 1.413 0.96
160_A 261_G 1.409 0.96
575_E 738_K 1.406 0.96
482_A 486_I 1.39 0.96
764_H 770_H 1.389 0.96
408_K 416_D 1.388 0.96
351_R 367_D 1.386 0.96
560_L 834_L 1.385 0.96
151_D 157_Q 1.383 0.96
744_V 747_H 1.382 0.96
802_L 806_N 1.377 0.95
773_S 776_Q 1.376 0.95
637_F 661_Y 1.375 0.95
459_E 463_K 1.374 0.95
559_L 588_R 1.367 0.95
14_L 91_L 1.353 0.95
343_V 346_T 1.35 0.95
425_E 440_R 1.346 0.95
167_D 238_L 1.339 0.94
676_L 693_V 1.338 0.94
638_M 688_N 1.338 0.94
690_L 693_V 1.337 0.94
647_V 689_I 1.336 0.94
259_L 262_V 1.335 0.94
289_A 293_M 1.334 0.94
117_E 133_T 1.324 0.94
169_T 172_A 1.32 0.94
474_T 477_A 1.319 0.94
377_S 389_K 1.315 0.94
481_Q 485_A 1.314 0.94
798_E 801_K 1.314 0.94
9_K 12_L 1.314 0.94
26_N 33_H 1.311 0.94
170_E 173_E 1.31 0.94
439_K 443_M 1.31 0.94
263_L 302_A 1.309 0.94
483_K 510_E 1.306 0.93
453_R 457_E 1.296 0.93
347_I 371_V 1.295 0.93
482_A 505_K 1.293 0.93
569_R 626_D 1.286 0.93
343_V 347_I 1.281 0.93
199_K 392_D 1.279 0.92
643_V 689_I 1.276 0.92
397_A 536_I 1.273 0.92
46_V 112_V 1.271 0.92
638_M 685_D 1.27 0.92
724_L 744_V 1.267 0.92
511_K 515_A 1.262 0.92
426_Q 441_L 1.262 0.92
284_V 329_L 1.262 0.92
370_I 394_I 1.261 0.92
133_T 137_T 1.26 0.92
783_Y 793_I 1.26 0.92
849_N 852_R 1.259 0.92
169_T 224_I 1.257 0.92
419_I 451_K 1.257 0.92
832_Q 835_S 1.256 0.92
795_I 846_L 1.255 0.92
160_A 265_D 1.254 0.91
415_L 451_K 1.254 0.91
775_A 800_L 1.252 0.91
772_A 800_L 1.251 0.91
234_G 272_N 1.247 0.91
499_S 502_Q 1.247 0.91
645_R 649_A 1.247 0.91
52_S 142_Q 1.242 0.91
169_T 177_L 1.241 0.91
475_I 509_L 1.239 0.91
377_S 386_L 1.239 0.91
632_I 645_R 1.238 0.91
796_S 799_A 1.238 0.91
280_L 312_G 1.236 0.91
122_L 126_L 1.235 0.91
414_R 418_R 1.235 0.91
555_E 588_R 1.233 0.91
467_A 471_G 1.231 0.90
510_E 514_E 1.231 0.90
463_K 467_A 1.231 0.90
158_R 162_K 1.226 0.90
802_L 824_Q 1.225 0.90
478_E 505_K 1.224 0.90
20_L 24_H 1.222 0.90
737_M 764_H 1.219 0.90
437_S 440_R 1.219 0.90
622_M 713_V 1.217 0.90
807_G 817_L 1.215 0.90
422_L 444_L 1.215 0.90
189_R 192_Q 1.211 0.89
795_I 800_L 1.201 0.89
208_P 385_Q 1.198 0.89
320_R 703_Q 1.196 0.89
482_A 501_L 1.196 0.89
36_S 61_R 1.196 0.89
354_K 367_D 1.196 0.89
453_R 456_S 1.194 0.89
791_Y 844_I 1.193 0.89
629_M 673_V 1.193 0.89
97_L 101_R 1.191 0.88
838_L 842_K 1.191 0.88
386_L 390_A 1.19 0.88
192_Q 400_S 1.177 0.88
798_E 848_V 1.172 0.87
562_M 581_S 1.172 0.87
586_R 827_N 1.172 0.87
785_R 826_E 1.172 0.87
695_D 818_K 1.171 0.87
496_A 499_S 1.17 0.87
397_A 539_V 1.17 0.87
482_A 509_L 1.167 0.87
450_D 454_Q 1.164 0.87
806_N 820_A 1.164 0.87
485_A 497_R 1.161 0.87
40_N 61_R 1.157 0.86
57_A 61_R 1.157 0.86
355_E 359_L 1.155 0.86
223_I 237_V 1.153 0.86
192_Q 399_S 1.149 0.86
439_K 442_D 1.149 0.86
132_T 135_N 1.148 0.86
41_Q 44_G 1.147 0.86
790_G 840_P 1.146 0.86
452_E 456_S 1.146 0.86
803_L 807_G 1.138 0.85
593_D 781_R 1.138 0.85
807_G 820_A 1.136 0.85
266_L 275_L 1.135 0.85
799_A 847_E 1.125 0.84
632_I 646_L 1.123 0.84
21_A 33_H 1.12 0.84
643_V 686_V 1.117 0.84
20_L 23_G 1.114 0.83
197_R 357_Y 1.114 0.83
828_P 852_R 1.113 0.83
20_L 37_A 1.11 0.83
195_Q 231_G 1.11 0.83
221_Q 225_N 1.109 0.83
6_L 10_F 1.107 0.83
249_A 262_V 1.107 0.83
416_D 459_E 1.107 0.83
60_L 125_I 1.105 0.83
63_D 129_A 1.104 0.83
195_Q 399_S 1.099 0.82
347_I 374_A 1.095 0.82
632_I 676_L 1.094 0.82
416_D 455_Y 1.094 0.82
16_D 37_A 1.093 0.82
560_L 831_Q 1.089 0.82
430_M 445_N 1.088 0.81
639_E 650_P 1.087 0.81
585_R 827_N 1.085 0.81
484_I 488_Q 1.084 0.81
563_E 581_S 1.083 0.81
345_D 348_A 1.083 0.81
490_R 493_G 1.082 0.81
676_L 716_M 1.079 0.81
479_L 482_A 1.077 0.81
566_L 617_A 1.075 0.80
734_Y 764_H 1.073 0.80
203_V 323_I 1.073 0.80
596_R 818_K 1.07 0.80
288_K 292_A 1.07 0.80
592_A 598_I 1.07 0.80
7_T 105_F 1.069 0.80
796_S 848_V 1.069 0.80
368_P 533_D 1.064 0.79
783_Y 787_E 1.063 0.79
107_S 149_V 1.061 0.79
7_T 107_S 1.056 0.79
172_A 177_L 1.056 0.79
666_V 674_I 1.055 0.79
346_T 386_L 1.055 0.79
478_E 481_Q 1.055 0.79
849_N 854_V 1.053 0.78
535_E 538_E 1.052 0.78
455_Y 459_E 1.05 0.78
180_V 187_I 1.049 0.78
776_Q 797_D 1.048 0.78
359_L 362_H 1.047 0.78
197_R 591_L 1.047 0.78
366_T 369_A 1.046 0.78
221_Q 224_I 1.044 0.78
787_E 792_E 1.044 0.78
205_I 335_K 1.04 0.77
480_E 484_I 1.04 0.77
745_V 760_V 1.04 0.77
419_I 455_Y 1.039 0.77
782_L 826_E 1.039 0.77
479_L 486_I 1.033 0.77
351_R 371_V 1.032 0.76
801_K 805_E 1.031 0.76
13_A 41_Q 1.031 0.76
489_A 494_D 1.027 0.76
486_I 502_Q 1.026 0.76
591_L 782_L 1.025 0.76
809_D 816_P 1.024 0.76
742_L 812_Y 1.023 0.76
242_M 283_M 1.023 0.76
347_I 375_T 1.022 0.75
474_T 478_E 1.021 0.75
411_E 454_Q 1.017 0.75
469_L 527_L 1.016 0.75
30_E 84_S 1.015 0.75
560_L 835_S 1.015 0.75
479_L 483_K 1.014 0.75
112_V 136_I 1.012 0.74
153_G 156_D 1.01 0.74
409_P 412_L 1.007 0.74
140_I 147_E 1.007 0.74
482_A 485_A 1.005 0.74
408_K 459_E 1.004 0.74
366_T 532_T 1.002 0.73
57_A 60_L 1.001 0.73
735_A 739_E 1 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qvrA30.98831000.403Contact Map0.795
1r6bX10.84951000.443Contact Map0.66
3pxiA30.87281000.469Contact Map0.764
3pxgA60.54031000.714Contact Map0.721
4hseA10.46321000.762Contact Map0.747
3vkgA20.82261000.816Contact Map0.361
4fcwA30.35711000.817Contact Map0.827
4akgA20.80631000.865Contact Map0.343
4b4tL10.47841000.871Contact Map0.425
1g41A10.32091000.875Contact Map0.581

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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