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AMIC - N-acetylmuramoyl-L-alanine amidase AmiC
UniProt: P63883 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13086
Length: 417 (400)
Sequences: 727
Seq/Len: 1.82

AMIC
Paralog alert: 0.48 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: AMIA AMIB AMIC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
339_V 370_I 5.408 1.00
227_E 234_V 2.909 1.00
262_V 403_I 2.697 1.00
210_R 213_D 2.668 1.00
219_A 236_M 2.41 1.00
194_P 219_A 2.384 1.00
221_R 393_Q 2.355 1.00
223_R 227_E 2.284 1.00
226_I 232_M 2.278 1.00
218_I 374_T 2.262 1.00
74_D 112_R 2.247 1.00
102_R 114_V 2.205 0.99
225_L 397_E 2.19 0.99
226_I 234_V 2.116 0.99
49_R 141_D 2.106 0.99
209_T 383_E 2.106 0.99
217_Q 392_Q 2.09 0.99
40_R 53_E 2.034 0.99
358_G 363_K 2.008 0.99
209_T 387_K 1.993 0.99
223_R 236_M 1.982 0.99
279_V 340_L 1.952 0.98
296_A 300_N 1.946 0.98
74_D 102_R 1.901 0.98
53_E 137_R 1.898 0.98
74_D 114_V 1.875 0.98
194_P 237_T 1.866 0.98
221_R 392_Q 1.864 0.98
70_R 114_V 1.835 0.97
65_L 114_V 1.817 0.97
102_R 116_E 1.778 0.97
107_D 110_T 1.777 0.97
51_T 137_R 1.767 0.97
50_V 115_F 1.719 0.96
260_L 403_I 1.719 0.96
40_R 137_R 1.711 0.96
205_G 383_E 1.71 0.96
102_R 112_R 1.707 0.96
223_R 234_V 1.695 0.95
217_Q 221_R 1.685 0.95
277_S 347_N 1.684 0.95
229_E 404_K 1.684 0.95
281_A 336_G 1.683 0.95
372_V 399_I 1.68 0.95
40_R 49_R 1.68 0.95
68_P 114_V 1.664 0.95
128_L 139_V 1.661 0.95
128_L 137_R 1.65 0.94
65_L 70_R 1.632 0.94
70_R 112_R 1.62 0.94
281_A 333_L 1.614 0.93
333_L 336_G 1.611 0.93
137_R 141_D 1.597 0.93
267_D 278_S 1.596 0.93
40_R 139_V 1.596 0.93
51_T 139_V 1.582 0.93
126_F 141_D 1.579 0.92
71_V 117_L 1.573 0.92
106_F 110_T 1.57 0.92
49_R 137_R 1.569 0.92
65_L 68_P 1.565 0.92
68_P 74_D 1.546 0.91
126_F 139_V 1.544 0.91
40_R 141_D 1.527 0.91
268_A 378_S 1.507 0.90
333_L 356_Q 1.493 0.89
75_I 78_V 1.488 0.89
53_E 139_V 1.469 0.88
130_P 141_D 1.448 0.87
300_N 359_F 1.437 0.87
70_R 74_D 1.434 0.87
204_V 210_R 1.433 0.87
68_P 102_R 1.408 0.85
66_S 69_E 1.403 0.85
49_R 139_V 1.394 0.85
40_R 128_L 1.393 0.84
63_F 72_V 1.386 0.84
40_R 126_F 1.377 0.84
292_A 296_A 1.367 0.83
232_M 375_A 1.358 0.82
192_L 234_V 1.354 0.82
191_M 237_T 1.353 0.82
229_E 400_L 1.333 0.81
49_R 128_L 1.332 0.81
65_L 74_D 1.326 0.80
40_R 51_T 1.319 0.80
300_N 303_D 1.319 0.80
54_S 58_L 1.318 0.80
104_G 114_V 1.309 0.79
65_L 102_R 1.293 0.78
190_I 260_L 1.29 0.78
205_G 214_V 1.29 0.78
73_V 115_F 1.286 0.77
226_I 400_L 1.275 0.76
379_N 383_E 1.26 0.75
315_Y 319_T 1.251 0.75
391_F 395_V 1.248 0.74
269_F 274_P 1.241 0.74
232_M 404_K 1.24 0.74
70_R 102_R 1.238 0.73
191_M 252_K 1.235 0.73
358_G 365_P 1.228 0.73
254_Q 366_D 1.226 0.72
206_K 380_V 1.225 0.72
53_E 128_L 1.222 0.72
42_W 126_F 1.219 0.72
288_T 296_A 1.217 0.72
68_P 112_R 1.213 0.71
300_N 332_S 1.212 0.71
194_P 240_E 1.21 0.71
296_A 303_D 1.207 0.71
128_L 141_D 1.203 0.70
260_L 335_F 1.202 0.70
189_V 233_K 1.194 0.70
63_F 74_D 1.181 0.68
63_F 114_V 1.179 0.68
49_R 126_F 1.178 0.68
261_F 300_N 1.176 0.68
65_L 112_R 1.172 0.67
296_A 359_F 1.171 0.67
328_T 358_G 1.17 0.67
40_R 48_T 1.169 0.67
189_V 235_Y 1.169 0.67
335_F 370_I 1.168 0.67
71_V 121_V 1.163 0.67
207_Y 383_E 1.159 0.66
292_A 300_N 1.159 0.66
248_V 251_A 1.158 0.66
316_V 402_G 1.155 0.66
267_D 279_V 1.152 0.66
19_A 26_S 1.142 0.65
377_I 407_F 1.142 0.65
19_A 25_V 1.141 0.64
277_S 349_L 1.138 0.64
73_V 140_M 1.136 0.64
218_I 395_V 1.135 0.64
130_P 136_E 1.133 0.64
329_I 354_V 1.13 0.63
72_V 114_V 1.129 0.63
74_D 116_E 1.128 0.63
275_S 381_E 1.125 0.63
42_W 199_E 1.125 0.63
332_S 359_F 1.124 0.63
336_G 356_Q 1.122 0.63
277_S 375_A 1.112 0.62
236_M 264_I 1.106 0.61
187_P 231_N 1.102 0.60
215_V 266_A 1.1 0.60
51_T 128_L 1.099 0.60
399_I 403_I 1.097 0.60
296_A 354_V 1.094 0.60
250_V 364_A 1.092 0.59
192_L 223_R 1.091 0.59
340_L 349_L 1.089 0.59
126_F 137_R 1.088 0.59
225_L 228_K 1.087 0.59
245_P 248_V 1.083 0.58
250_V 358_G 1.078 0.58
382_E 391_F 1.07 0.57
51_T 141_D 1.069 0.57
44_A 199_E 1.068 0.57
246_L 359_F 1.067 0.57
72_V 112_R 1.066 0.57
354_V 359_F 1.062 0.56
38_A 53_E 1.061 0.56
339_V 399_I 1.061 0.56
155_L 190_I 1.056 0.56
291_A 325_Q 1.053 0.55
28_V 32_A 1.047 0.55
264_I 374_T 1.044 0.54
278_S 391_F 1.04 0.54
325_Q 328_T 1.038 0.54
74_D 104_G 1.038 0.54
191_M 234_V 1.032 0.53
16_G 24_S 1.032 0.53
269_F 272_R 1.03 0.53
18_G 25_V 1.028 0.53
18_G 26_S 1.028 0.53
104_G 116_E 1.027 0.52
68_P 72_V 1.026 0.52
17_A 24_S 1.025 0.52
53_E 141_D 1.022 0.52
382_E 398_S 1.018 0.51
219_A 239_N 1.018 0.51
17_A 26_S 1.016 0.51
70_R 116_E 1.013 0.51
191_M 258_A 1.01 0.51
42_W 137_R 1.01 0.51
98_I 117_L 1.008 0.50
267_D 340_L 1.008 0.50
332_S 358_G 1.008 0.50
274_P 350_H 1.005 0.50
75_I 343_L 1.005 0.50
267_D 366_D 1.003 0.50
377_I 392_Q 1.003 0.50
281_A 356_Q 1.002 0.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4binA10.96641000.229Contact Map0.579
3ne8A10.55881000.465Contact Map0.614
1jwqA10.42691000.546Contact Map0.619
4m6gA10.471000.557Contact Map0.59
1xovA10.46281000.559Contact Map0.652
3czxA40.42211000.575Contact Map0.624
3qayA40.41011000.59Contact Map0.636
4av2A120.834599.20.897Contact Map0.014
4aqzA10.321394.60.952Contact Map0.375
3zhnA10.34298.40.98Contact Map0.033

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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