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MLAB - Probable phospholipid ABC transporter-binding protein MlaB
UniProt: P64602 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12797
Length: 97 (97)
Sequences: 179
Seq/Len: 1.85

MLAB
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
57_L 90_L 2.686 1.00
85_A 95_L 2.255 1.00
60_H 89_N 1.871 0.98
28_L 57_L 1.822 0.97
19_E 93_D 1.583 0.93
35_A 52_T 1.562 0.92
49_R 89_N 1.525 0.91
53_G 78_N 1.502 0.90
84_L 87_L 1.444 0.87
3_E 8_M 1.34 0.82
38_G 52_T 1.32 0.80
12_D 47_V 1.316 0.80
83_T 87_L 1.303 0.79
29_W 32_R 1.3 0.79
29_W 61_L 1.299 0.79
15_A 46_R 1.295 0.78
17_S 68_Q 1.278 0.77
36_V 52_T 1.266 0.76
60_H 86_K 1.225 0.73
61_L 95_L 1.211 0.72
12_D 15_A 1.209 0.71
9_Q 38_G 1.2 0.71
29_W 87_L 1.198 0.70
28_L 90_L 1.176 0.68
47_V 92_A 1.176 0.68
60_H 87_L 1.176 0.68
49_R 53_G 1.158 0.67
27_P 57_L 1.157 0.67
30_E 46_R 1.155 0.66
23_D 77_V 1.135 0.64
22_Q 26_L 1.128 0.64
76_G 80_K 1.128 0.64
33_E 95_L 1.119 0.63
2_S 23_D 1.118 0.63
52_T 91_P 1.113 0.62
65_A 72_V 1.083 0.59
22_Q 31_M 1.08 0.59
8_M 17_S 1.074 0.58
49_R 60_H 1.069 0.57
66_K 74_L 1.05 0.55
53_G 62_I 1.049 0.55
59_L 88_Y 1.046 0.55
78_N 85_A 1.041 0.54
61_L 87_L 1.034 0.54
7_W 32_R 1.013 0.51
63_D 89_N 1.009 0.51
2_S 96_P 1.006 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1th8B10.989799.10.598Contact Map0.192
1sboA10.989799.10.601Contact Map0.154
4hylA20.989799.10.601Contact Map0.154
1h4xA20.9691990.62Contact Map0.215
2ka5A10.9897990.62Contact Map0.145
3t6oA30.9794990.623Contact Map0.177
3zxnA20.989798.90.628Contact Map0.175
3oizA10.948598.90.63Contact Map0.206
2klnA10.989798.90.631Contact Map0.104
4dghA20.989798.90.631Contact Map0.128

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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