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RSMI - Ribosomal RNA small subunit methyltransferase I
UniProt: P67087 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12777
Length: 286 (275)
Sequences: 1794
Seq/Len: 6.52

RSMI
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
49_T 90_V 5.55 1.00
25_A 33_E 4.614 1.00
80_K 85_Q 3.438 1.00
191_Y 233_E 3.069 1.00
29_Q 32_L 3.048 1.00
18_P 119_L 2.988 1.00
33_E 37_A 2.963 1.00
192_V 213_L 2.869 1.00
82_Q 112_A 2.74 1.00
192_V 210_V 2.593 1.00
110_R 207_G 2.519 1.00
131_A 205_I 2.334 1.00
27_I 32_L 2.234 1.00
108_T 111_E 2.233 1.00
152_R 181_D 2.156 1.00
39_D 86_N 2.105 1.00
32_L 56_F 2.089 1.00
17_V 31_A 2.086 1.00
124_A 169_Y 2.015 1.00
145_L 155_A 1.927 1.00
118_P 205_I 1.922 1.00
145_L 156_L 1.905 1.00
42_A 77_L 1.868 1.00
50_G 54_Q 1.834 1.00
182_I 210_V 1.833 1.00
138_R 142_E 1.829 1.00
195_A 205_I 1.82 1.00
40_L 87_I 1.792 1.00
182_I 232_V 1.792 1.00
193_V 205_I 1.721 1.00
142_E 164_R 1.703 1.00
18_P 95_T 1.699 1.00
82_Q 114_I 1.697 1.00
168_F 232_V 1.697 1.00
142_E 155_A 1.686 1.00
170_E 174_R 1.678 1.00
157_K 160_E 1.671 1.00
38_V 86_N 1.654 1.00
66_H 69_N 1.636 1.00
140_C 164_R 1.632 1.00
194_L 228_M 1.628 1.00
125_A 169_Y 1.599 1.00
188_E 211_G 1.572 0.99
78_L 82_Q 1.568 0.99
99_N 141_Y 1.567 0.99
146_P 155_A 1.558 0.99
153_R 181_D 1.555 0.99
196_R 204_T 1.551 0.99
249_T 269_I 1.516 0.99
109_C 114_I 1.506 0.99
38_V 88_A 1.503 0.99
13_Q 115_R 1.501 0.99
17_V 88_A 1.491 0.99
183_V 214_L 1.479 0.99
123_C 126_I 1.478 0.99
95_T 130_S 1.474 0.99
39_D 85_Q 1.474 0.99
249_T 270_H 1.458 0.99
140_C 162_E 1.457 0.99
263_A 267_A 1.449 0.99
206_H 213_L 1.449 0.99
27_I 56_F 1.44 0.99
43_A 62_L 1.429 0.99
180_E 218_K 1.421 0.99
14_L 81_L 1.421 0.99
65_L 74_A 1.42 0.99
117_V 203_E 1.415 0.99
178_S 230_L 1.406 0.99
175_L 217_V 1.403 0.99
190_R 234_G 1.401 0.99
80_K 83_E 1.399 0.99
40_L 80_K 1.391 0.98
13_Q 117_V 1.39 0.98
208_A 212_E 1.388 0.98
73_K 76_T 1.387 0.98
81_L 114_I 1.373 0.98
258_P 261_K 1.37 0.98
63_F 73_K 1.357 0.98
18_P 127_T 1.356 0.98
118_P 130_S 1.354 0.98
118_P 131_A 1.347 0.98
70_E 104_H 1.347 0.98
16_I 106_V 1.346 0.98
193_V 231_I 1.333 0.98
119_L 127_T 1.33 0.98
64_A 73_K 1.321 0.98
208_A 213_L 1.29 0.97
189_S 211_G 1.281 0.97
125_A 167_I 1.272 0.97
150_K 154_D 1.257 0.97
17_V 34_V 1.253 0.96
42_A 87_I 1.246 0.96
41_I 53_L 1.239 0.96
259_L 263_A 1.22 0.96
265_L 269_I 1.216 0.96
209_P 212_E 1.215 0.96
13_Q 81_L 1.207 0.95
103_Y 135_P 1.207 0.95
264_A 274_K 1.204 0.95
79_A 83_E 1.201 0.95
217_V 224_R 1.197 0.95
153_R 157_K 1.195 0.95
263_A 281_A 1.195 0.95
42_A 63_F 1.193 0.95
215_A 218_K 1.19 0.95
15_Y 38_V 1.179 0.95
262_A 266_A 1.177 0.94
74_A 108_T 1.176 0.94
123_C 169_Y 1.17 0.94
182_I 186_L 1.155 0.94
108_T 112_A 1.154 0.94
187_G 210_V 1.152 0.94
183_V 210_V 1.143 0.93
149_S 181_D 1.142 0.93
175_L 230_L 1.141 0.93
95_T 118_P 1.128 0.93
74_A 78_L 1.128 0.93
156_L 182_I 1.114 0.92
194_L 217_V 1.11 0.92
259_L 281_A 1.097 0.91
65_L 70_E 1.09 0.91
166_L 232_V 1.079 0.90
175_L 194_L 1.076 0.90
127_T 198_L 1.073 0.90
206_H 216_W 1.071 0.90
27_I 31_A 1.069 0.90
147_A 174_R 1.068 0.90
153_R 184_A 1.06 0.89
254_Q 281_A 1.051 0.89
117_V 131_A 1.047 0.88
79_A 82_Q 1.047 0.88
75_E 108_T 1.044 0.88
257_L 265_L 1.032 0.88
245_D 248_R 1.029 0.87
97_L 103_Y 1.024 0.87
252_L 269_I 1.01 0.86
183_V 211_G 1.008 0.86
247_L 251_A 1.003 0.85
216_W 224_R 1 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kwpA10.9931000.339Contact Map0.76
1wyzA40.80421000.6Contact Map0.727
1cbfA10.90911000.614Contact Map0.564
4e16A10.86011000.619Contact Map0.58
1s4dA120.91961000.629Contact Map0.648
3ndcA20.88461000.634Contact Map0.568
2yboA10.93361000.635Contact Map0.541
1ve2A20.78321000.647Contact Map0.665
1pjqA20.84621000.648Contact Map0.614
1va0A20.79021000.648Contact Map0.669

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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