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AAER - HTH-type transcriptional activator AaeR
UniProt: P67662 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12825
Length: 309 (292)
Sequences: 36258
Seq/Len: 124.17

AAER
Paralog alert: 0.88 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
71_R 75_E 3.823 1.00
16_F 25_Q 3.456 1.00
156_R 289_T 2.607 1.00
230_L 237_A 2.558 1.00
97_G 139_L 2.503 1.00
21_A 24_R 2.42 1.00
68_G 82_Q 2.377 1.00
12_K 25_Q 2.259 1.00
162_P 241_L 2.243 1.00
15_E 70_R 2.242 1.00
95_R 124_N 2.209 1.00
93_T 124_N 2.197 1.00
93_T 122_S 2.193 1.00
180_K 183_D 2.186 1.00
157_R 160_A 2.135 1.00
72_M 76_V 2.124 1.00
68_G 75_E 2.101 1.00
113_K 291_Y 2.09 1.00
14_V 58_L 2.079 1.00
9_V 36_T 2.047 1.00
11_A 66_Y 2.029 1.00
227_V 247_E 2.017 1.00
160_A 266_P 1.988 1.00
19_F 37_V 1.979 1.00
66_Y 70_R 1.974 1.00
46_V 61_A 1.972 1.00
171_Y 187_H 1.955 1.00
12_K 16_F 1.942 1.00
11_A 70_R 1.932 1.00
11_A 15_E 1.913 1.00
12_K 15_E 1.903 1.00
50_N 57_G 1.866 1.00
9_V 33_I 1.863 1.00
113_K 287_S 1.848 1.00
157_R 266_P 1.841 1.00
65_Y 79_V 1.82 1.00
114_M 121_L 1.809 1.00
231_T 247_E 1.804 1.00
190_L 235_G 1.77 1.00
14_V 66_Y 1.767 1.00
164_V 241_L 1.767 1.00
188_S 217_R 1.729 1.00
231_T 252_E 1.714 1.00
11_A 69_C 1.698 1.00
10_F 66_Y 1.693 1.00
64_I 82_Q 1.693 1.00
60_E 63_R 1.672 1.00
9_V 28_M 1.666 1.00
15_E 25_Q 1.661 1.00
16_F 21_A 1.656 1.00
18_S 21_A 1.646 1.00
20_T 30_V 1.637 1.00
29_S 32_S 1.626 1.00
89_T 120_G 1.584 1.00
11_A 73_L 1.575 1.00
114_M 284_V 1.564 1.00
68_G 78_D 1.515 1.00
72_M 79_V 1.507 1.00
160_A 264_P 1.493 1.00
104_Q 224_M 1.493 1.00
141_V 281_V 1.467 1.00
12_K 26_L 1.459 1.00
6_R 39_K 1.457 1.00
113_K 117_E 1.438 1.00
47_K 50_N 1.431 1.00
6_R 43_E 1.428 1.00
65_Y 80_H 1.426 1.00
6_R 36_T 1.42 1.00
190_L 226_L 1.418 1.00
164_V 255_I 1.401 0.99
4_L 76_V 1.396 0.99
63_R 67_Q 1.392 0.99
91_I 120_G 1.385 0.99
245_I 249_N 1.383 0.99
155_S 268_Y 1.374 0.99
269_A 285_I 1.361 0.99
38_S 42_D 1.356 0.99
187_H 236_I 1.353 0.99
167_A 171_Y 1.345 0.99
226_L 237_A 1.341 0.99
68_G 71_R 1.333 0.99
112_A 116_K 1.324 0.99
113_K 116_K 1.316 0.99
285_I 289_T 1.311 0.99
247_E 252_E 1.305 0.99
114_M 287_S 1.305 0.99
43_E 80_H 1.303 0.99
35_Q 38_S 1.284 0.99
133_D 138_G 1.276 0.99
115_L 188_S 1.276 0.99
283_V 286_N 1.274 0.99
177_I 254_E 1.274 0.99
103_A 127_T 1.272 0.99
10_F 14_V 1.27 0.99
277_L 281_V 1.261 0.99
167_A 236_I 1.259 0.99
67_Q 71_R 1.24 0.98
68_G 79_V 1.238 0.98
220_T 226_L 1.237 0.98
228_R 231_T 1.237 0.98
95_R 126_V 1.224 0.98
28_M 32_S 1.219 0.98
52_S 57_G 1.215 0.98
75_E 78_D 1.215 0.98
13_V 37_V 1.205 0.98
134_L 142_V 1.202 0.98
154_F 271_Y 1.196 0.98
64_I 67_Q 1.19 0.98
117_E 287_S 1.188 0.98
10_F 49_L 1.182 0.98
94_L 284_V 1.177 0.98
10_F 48_L 1.176 0.98
19_F 56_I 1.173 0.98
154_F 273_E 1.172 0.98
13_V 22_A 1.168 0.97
34_S 38_S 1.162 0.97
241_L 245_I 1.157 0.97
8_S 77_Q 1.155 0.97
115_L 217_R 1.154 0.97
179_E 183_D 1.151 0.97
14_V 49_L 1.139 0.97
3_R 6_R 1.138 0.97
58_L 62_G 1.132 0.97
246_N 250_R 1.132 0.97
141_V 269_A 1.129 0.97
161_M 242_M 1.126 0.97
255_I 258_P 1.121 0.97
36_T 39_K 1.12 0.96
175_Y 183_D 1.119 0.96
35_Q 39_K 1.114 0.96
12_K 22_A 1.111 0.96
167_A 256_L 1.109 0.96
241_L 255_I 1.107 0.96
112_A 232_A 1.107 0.96
156_R 271_Y 1.098 0.96
114_M 118_Y 1.094 0.96
7_M 69_C 1.091 0.96
286_N 289_T 1.089 0.96
64_I 68_G 1.088 0.96
282_Q 286_N 1.088 0.96
227_V 231_T 1.086 0.96
5_K 8_S 1.079 0.95
133_D 136_A 1.077 0.95
200_F 204_A 1.073 0.95
72_M 75_E 1.07 0.95
228_R 232_A 1.068 0.95
28_M 33_I 1.067 0.95
49_L 56_I 1.064 0.95
117_E 290_D 1.062 0.95
65_Y 69_C 1.057 0.95
71_R 78_D 1.054 0.95
166_C 244_V 1.048 0.94
77_Q 81_E 1.048 0.94
118_Y 283_V 1.044 0.94
124_N 219_V 1.041 0.94
157_R 268_Y 1.035 0.94
271_Y 285_I 1.028 0.94
165_V 236_I 1.014 0.93
14_V 62_G 1.014 0.93
109_G 232_A 1.005 0.93
171_Y 188_S 1.004 0.93
13_V 19_F 1.001 0.92
96_I 141_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3hhgA80.98381000.17Contact Map0.93
3szpA20.94171000.174Contact Map0.779
3fxqA20.96761000.176Contact Map0.781
2esnA40.95471000.18Contact Map0.759
1ixcA20.93531000.186Contact Map0.764
3fzvA40.96121000.188Contact Map0.711
1al3A10.98711000.189Contact Map0.743
1uthA10.96761000.191Contact Map0.771
3mz1A40.96121000.197Contact Map0.78
2h98A20.98061000.203Contact Map0.736

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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