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AMPA - Cytosol aminopeptidase
UniProt: P68767 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10694
Length: 503 (495)
Sequences: 1696
Seq/Len: 3.43

AMPA
Paralog alert: 0.13 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: AMPA PEPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
321_A 362_V 3.436 1.00
340_T 346_V 3.352 1.00
396_M 447_A 3.267 1.00
400_N 419_R 3.179 1.00
207_A 301_Y 3.175 1.00
235_S 346_V 3.135 1.00
272_L 323_C 3.11 1.00
321_A 358_V 3.014 1.00
191_G 295_C 2.992 1.00
224_G 227_Q 2.929 1.00
396_M 451_G 2.891 1.00
428_E 431_E 2.88 1.00
384_C 394_G 2.847 1.00
250_S 322_G 2.832 1.00
307_V 312_L 2.771 1.00
221_R 253_E 2.755 1.00
363_L 454_L 2.545 1.00
183_G 302_G 2.459 1.00
307_V 316_V 2.456 1.00
240_G 247_S 2.359 1.00
267_L 300_V 2.324 1.00
393_T 484_R 2.284 1.00
203_L 322_G 2.276 1.00
344_Q 456_R 2.223 1.00
392_I 423_G 2.21 1.00
199_N 245_N 2.171 1.00
224_G 248_L 2.142 1.00
238_A 338_L 2.108 1.00
279_I 327_P 2.083 1.00
349_L 440_I 2.066 1.00
276_S 326_M 2.048 1.00
176_H 494_L 2.042 1.00
235_S 340_T 2.008 1.00
265_I 493_L 2 1.00
238_A 332_Y 1.996 1.00
272_L 358_V 1.996 1.00
337_V 434_F 1.989 1.00
227_Q 230_E 1.979 1.00
36_D 41_G 1.965 1.00
301_Y 320_L 1.922 1.00
427_Q 456_R 1.921 1.00
244_Q 330_R 1.899 1.00
310_L 490_A 1.898 1.00
403_A 419_R 1.877 1.00
406_L 464_A 1.867 0.99
203_L 297_A 1.854 0.99
228_M 249_M 1.842 0.99
250_S 320_L 1.838 0.99
240_G 323_C 1.832 0.99
319_V 366_V 1.829 0.99
376_D 463_W 1.811 0.99
224_G 246_E 1.8 0.99
338_L 348_V 1.783 0.99
195_P 335_G 1.774 0.99
249_M 362_V 1.773 0.99
349_L 438_A 1.771 0.99
383_A 446_G 1.76 0.99
420_L 447_A 1.758 0.99
397_A 403_A 1.735 0.99
396_M 420_L 1.735 0.99
395_L 466_L 1.733 0.99
203_L 250_S 1.719 0.99
219_I 253_E 1.711 0.99
211_A 220_T 1.666 0.99
386_I 443_R 1.656 0.98
229_K 241_Q 1.656 0.98
189_D 192_N 1.641 0.98
377_V 489_L 1.64 0.98
200_A 324_E 1.637 0.98
339_T 345_T 1.635 0.98
257_N 261_D 1.634 0.98
198_C 202_Y 1.629 0.98
228_M 236_Y 1.615 0.98
201_A 245_N 1.601 0.98
271_G 297_A 1.6 0.98
386_I 444_P 1.594 0.98
341_M 364_T 1.588 0.98
97_I 133_A 1.588 0.98
393_T 471_T 1.572 0.98
54_G 77_G 1.569 0.98
433_N 479_K 1.569 0.98
300_V 318_G 1.568 0.98
182_A 309_E 1.566 0.98
491_Q 495_N 1.563 0.98
213_S 305_R 1.542 0.97
256_G 315_N 1.53 0.97
235_S 338_L 1.527 0.97
244_Q 328_G 1.521 0.97
432_S 435_A 1.511 0.97
199_N 202_Y 1.508 0.97
133_A 157_M 1.503 0.97
307_V 493_L 1.494 0.97
395_L 403_A 1.49 0.96
206_Q 209_Q 1.489 0.96
304_M 307_V 1.483 0.96
294_M 298_A 1.482 0.96
342_S 364_T 1.48 0.96
225_E 247_S 1.464 0.96
437_M 456_R 1.462 0.96
393_T 485_P 1.46 0.96
140_F 143_L 1.454 0.96
234_H 339_T 1.449 0.96
393_T 466_L 1.438 0.95
264_P 317_I 1.431 0.95
179_A 183_G 1.429 0.95
288_D 349_L 1.425 0.95
138_Y 189_D 1.425 0.95
127_R 176_H 1.422 0.95
280_S 284_S 1.418 0.95
407_I 417_A 1.417 0.95
384_C 447_A 1.412 0.95
100_L 108_A 1.408 0.95
281_I 284_S 1.403 0.95
143_L 193_M 1.402 0.95
90_K 131_E 1.399 0.94
245_N 333_R 1.381 0.94
384_C 420_L 1.38 0.94
305_R 309_E 1.379 0.94
225_E 229_K 1.379 0.94
21_G 78_C 1.378 0.94
217_N 311_Q 1.375 0.94
143_L 197_I 1.372 0.94
233_M 341_M 1.362 0.93
272_L 321_A 1.356 0.93
344_Q 437_M 1.348 0.93
236_Y 323_C 1.347 0.93
233_M 365_Y 1.337 0.93
240_G 324_E 1.332 0.92
385_V 444_P 1.332 0.92
242_G 327_P 1.331 0.92
340_T 364_T 1.331 0.92
399_H 462_N 1.33 0.92
402_L 464_A 1.322 0.92
211_A 252_I 1.319 0.92
225_E 246_E 1.313 0.92
280_S 287_M 1.31 0.92
241_Q 332_Y 1.309 0.92
395_L 464_A 1.309 0.92
140_F 189_D 1.309 0.92
225_E 240_G 1.309 0.92
367_E 461_Y 1.306 0.91
212_D 230_E 1.306 0.91
184_I 487_A 1.306 0.91
235_S 360_C 1.295 0.91
251_V 317_I 1.291 0.91
300_V 377_V 1.29 0.91
236_Y 249_M 1.286 0.91
173_A 177_G 1.281 0.90
205_S 209_Q 1.267 0.90
201_A 248_L 1.261 0.89
417_A 488_L 1.254 0.89
187_A 299_A 1.245 0.89
357_L 439_N 1.243 0.88
253_E 369_F 1.243 0.88
183_G 306_M 1.242 0.88
392_I 416_R 1.241 0.88
266_V 366_V 1.239 0.88
318_G 377_V 1.239 0.88
177_G 181_A 1.239 0.88
191_G 472_A 1.234 0.88
200_A 240_G 1.234 0.88
214_Y 305_R 1.232 0.88
292_Y 473_W 1.225 0.87
483_G 486_V 1.224 0.87
200_A 273_T 1.219 0.87
407_I 419_R 1.218 0.87
312_L 493_L 1.216 0.87
367_E 459_R 1.21 0.87
297_A 320_L 1.207 0.86
126_V 173_A 1.207 0.86
304_M 318_G 1.205 0.86
303_V 307_V 1.204 0.86
366_V 374_V 1.191 0.85
241_Q 330_R 1.188 0.85
332_Y 357_L 1.182 0.85
323_C 358_V 1.18 0.85
24_E 80_K 1.175 0.84
251_V 365_Y 1.174 0.84
199_N 333_R 1.174 0.84
265_I 373_A 1.17 0.84
319_V 362_V 1.168 0.84
430_L 440_I 1.168 0.84
350_N 446_G 1.166 0.84
422_L 451_G 1.163 0.84
196_N 279_I 1.157 0.83
208_R 212_D 1.156 0.83
358_V 362_V 1.15 0.83
255_K 315_N 1.146 0.82
375_I 492_F 1.145 0.82
306_M 490_A 1.144 0.82
223_I 231_L 1.143 0.82
225_E 248_L 1.141 0.82
264_P 372_E 1.134 0.81
332_Y 348_V 1.132 0.81
385_V 447_A 1.128 0.81
143_L 337_V 1.126 0.81
135_E 487_A 1.126 0.81
280_S 349_L 1.126 0.81
303_V 490_A 1.124 0.81
363_L 374_V 1.121 0.80
340_T 453_F 1.119 0.80
405_E 496_R 1.117 0.80
202_Y 206_Q 1.112 0.80
350_N 383_A 1.111 0.80
228_M 341_M 1.109 0.79
211_A 218_V 1.109 0.79
445_G 448_I 1.107 0.79
446_G 449_T 1.107 0.79
253_E 315_N 1.107 0.79
142_Q 193_M 1.106 0.79
80_K 83_E 1.102 0.79
131_E 487_A 1.1 0.79
231_L 341_M 1.098 0.78
179_A 310_L 1.097 0.78
237_L 241_Q 1.097 0.78
204_A 250_S 1.097 0.78
314_I 493_L 1.091 0.78
267_L 303_V 1.086 0.77
134_K 181_A 1.08 0.77
232_G 341_M 1.079 0.77
204_A 222_V 1.076 0.76
373_A 492_F 1.074 0.76
266_V 317_I 1.069 0.76
16_A 107_E 1.068 0.76
338_L 357_L 1.066 0.75
138_Y 192_N 1.065 0.75
223_I 227_Q 1.063 0.75
367_E 460_K 1.062 0.75
448_I 452_C 1.061 0.75
218_V 304_M 1.06 0.75
228_M 233_M 1.057 0.75
203_L 301_Y 1.056 0.75
108_A 154_L 1.055 0.74
415_D 484_R 1.052 0.74
266_V 319_V 1.05 0.74
416_R 423_G 1.049 0.74
377_V 485_P 1.048 0.74
317_I 369_F 1.043 0.73
135_E 188_K 1.043 0.73
204_A 220_T 1.04 0.73
263_R 372_E 1.039 0.73
252_I 301_Y 1.037 0.73
249_M 358_V 1.035 0.72
395_L 488_L 1.035 0.72
426_Y 448_I 1.031 0.72
332_Y 338_L 1.03 0.72
375_I 493_L 1.025 0.71
431_E 456_R 1.023 0.71
207_A 250_S 1.021 0.71
218_V 308_A 1.021 0.71
183_G 187_A 1.018 0.71
85_D 88_Q 1.016 0.70
303_V 489_L 1.016 0.70
61_L 74_L 1.013 0.70
406_L 417_A 1.005 0.69
101_N 139_S 1.004 0.69
187_A 302_G 1.003 0.69
299_A 303_V 1.002 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gytA120.9981000.046Contact Map0.798
3h8gF60.98411000.055Contact Map0.805
3jruB20.97021000.06Contact Map0.772
3peiA10.95431000.075Contact Map0.759
4ksiA10.96221000.097Contact Map0.734
3kzwA120.96221000.097Contact Map0.749
1lamA10.91651000.105Contact Map0.716
3kr4A120.97611000.115Contact Map0.778
3ij3A10.90261000.16Contact Map0.709
4efdA60.93841000.2Contact Map0.681

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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