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BAER - Transcriptional regulatory protein BaeR
UniProt: P69228 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11618
Length: 240 (222)
Sequences: 28233
Seq/Len: 127.18

BAER
Paralog alert: 0.94 [within 20: 0.56] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_G 39_L 3.522 1.00
23_G 41_S 2.865 1.00
44_D 66_G 2.657 1.00
27_I 39_L 2.538 1.00
42_H 66_G 2.494 1.00
16_V 46_V 2.463 1.00
67_T 75_E 2.403 1.00
38_T 55_P 2.345 1.00
164_A 167_R 2.284 1.00
93_E 113_S 2.241 1.00
27_I 31_R 2.228 1.00
199_R 202_D 2.222 1.00
182_R 202_D 2.217 1.00
43_G 67_T 2.142 1.00
42_H 45_Q 2.126 1.00
165_E 211_K 2.075 1.00
51_R 79_F 2.063 1.00
96_R 116_E 2.049 1.00
29_Y 114_P 2.021 1.00
12_R 36_A 2.007 1.00
47_L 75_E 1.999 1.00
68_D 71_T 1.945 1.00
142_P 155_R 1.937 1.00
41_S 45_Q 1.882 1.00
12_R 38_T 1.852 1.00
170_K 174_H 1.838 1.00
57_L 121_V 1.802 1.00
40_I 49_Y 1.787 1.00
223_R 233_E 1.779 1.00
151_Q 158_M 1.767 1.00
86_M 99_G 1.755 1.00
30_L 121_V 1.728 1.00
73_C 84_I 1.727 1.00
204_H 207_N 1.708 1.00
139_A 144_I 1.691 1.00
85_V 124_I 1.685 1.00
62_L 86_M 1.679 1.00
60_L 72_L 1.646 1.00
144_I 153_S 1.629 1.00
60_L 73_C 1.627 1.00
145_I 173_S 1.624 1.00
223_R 231_R 1.623 1.00
101_E 122_K 1.616 1.00
63_M 90_K 1.61 1.00
175_E 178_K 1.604 1.00
105_D 127_R 1.593 1.00
171_T 185_L 1.589 1.00
33_A 118_V 1.587 1.00
75_E 78_R 1.548 1.00
14_L 40_I 1.539 1.00
171_T 188_H 1.521 1.00
73_C 86_M 1.497 1.00
181_S 184_Q 1.465 1.00
90_K 95_D 1.457 1.00
16_V 64_L 1.453 1.00
86_M 104_A 1.451 1.00
58_I 82_I 1.442 1.00
38_T 49_Y 1.41 1.00
17_E 23_G 1.406 0.99
67_T 71_T 1.403 0.99
43_G 72_L 1.398 0.99
106_D 120_R 1.394 0.99
47_L 72_L 1.384 0.99
77_R 105_D 1.373 0.99
70_L 102_I 1.357 0.99
146_D 149_R 1.314 0.99
180_F 188_H 1.312 0.99
71_T 74_R 1.306 0.99
44_D 67_T 1.294 0.99
75_E 79_F 1.287 0.99
62_L 70_L 1.28 0.99
49_Y 53_T 1.276 0.99
48_P 52_Q 1.27 0.99
49_Y 52_Q 1.262 0.99
176_P 180_F 1.251 0.99
47_L 67_T 1.204 0.98
50_V 76_I 1.202 0.98
44_D 48_P 1.2 0.98
205_I 209_R 1.199 0.98
33_A 122_K 1.199 0.98
35_Y 122_K 1.198 0.98
171_T 180_F 1.193 0.98
225_V 231_R 1.185 0.98
150_F 167_R 1.184 0.98
57_L 125_L 1.183 0.98
20_P 41_S 1.178 0.98
153_S 158_M 1.155 0.97
74_R 98_L 1.148 0.97
40_I 46_V 1.144 0.97
34_S 122_K 1.134 0.97
45_Q 48_P 1.133 0.97
92_E 95_D 1.12 0.96
200_T 204_H 1.116 0.96
18_D 61_D 1.112 0.96
124_I 127_R 1.108 0.96
38_T 53_T 1.104 0.96
178_K 184_Q 1.1 0.96
26_L 87_V 1.1 0.96
147_E 170_K 1.099 0.96
203_S 206_K 1.095 0.96
46_V 50_V 1.09 0.96
13_I 35_Y 1.09 0.96
214_S 224_A 1.088 0.96
94_I 98_L 1.06 0.95
15_I 37_P 1.055 0.95
63_M 89_A 1.054 0.95
45_Q 49_Y 1.048 0.94
16_V 58_I 1.047 0.94
183_E 198_D 1.045 0.94
97_L 115_R 1.044 0.94
183_E 187_N 1.043 0.94
14_L 46_V 1.041 0.94
70_L 98_L 1.039 0.94
14_L 55_P 1.039 0.94
58_I 76_I 1.026 0.94
171_T 175_E 1.022 0.93
49_Y 55_P 1.019 0.93
140_E 232_W 1.016 0.93
64_L 72_L 1.015 0.93
150_F 228_V 1.015 0.93
145_I 166_F 1.014 0.93
148_G 178_K 1.014 0.93
167_R 170_K 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4b09A1211000.155Contact Map0.676
2gwrA10.97081000.179Contact Map0.676
1ys7A20.96251000.181Contact Map0.765
3r0jA20.9751000.185Contact Map0.694
2oqrA10.951000.196Contact Map0.563
1kgsA10.93331000.206Contact Map0.721
1p2fA10.91251000.228Contact Map0.756
2hqrA20.91671000.236Contact Map0.696
3q9sA10.9251000.245Contact Map0.669
3c3wA20.91000.323Contact Map0.612

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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