GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
CUTA - Divalent-cation tolerance protein CutA
UniProt: P69488 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12177
Length: 112 (103)
Sequences: 829
Seq/Len: 8.05

CUTA
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
34_E 79_C 2.94 1.00
23_T 85_P 2.782 1.00
73_Q 77_L 2.746 1.00
99_G 104_L 2.698 1.00
32_L 49_L 2.486 1.00
25_Q 58_Q 2.172 1.00
40_A 66_L 2.154 1.00
37_A 66_L 2.094 1.00
19_P 85_P 2.07 1.00
79_C 83_H 1.949 1.00
29_A 58_Q 1.939 1.00
16_C 80_L 1.796 1.00
53_E 87_Q 1.73 1.00
11_S 107_L 1.683 1.00
72_H 75_A 1.674 1.00
63_Q 90_E 1.602 1.00
14_V 76_L 1.535 1.00
30_K 79_C 1.522 1.00
16_C 66_L 1.503 1.00
81_K 102_D 1.491 0.99
19_P 23_T 1.423 0.99
41_T 63_Q 1.422 0.99
20_D 23_T 1.395 0.99
27_L 83_H 1.389 0.99
21_E 25_Q 1.385 0.99
69_T 72_H 1.382 0.99
50_Y 59_E 1.364 0.99
25_Q 47_T 1.345 0.99
31_V 66_L 1.34 0.99
43_I 65_I 1.336 0.99
18_A 64_M 1.327 0.99
73_Q 93_V 1.307 0.98
15_L 90_E 1.3 0.98
31_V 76_L 1.29 0.98
96_V 99_G 1.28 0.98
88_T 100_D 1.254 0.98
72_H 111_L 1.238 0.97
12_V 73_Q 1.214 0.97
90_E 103_Y 1.208 0.97
40_A 64_M 1.203 0.97
92_L 96_V 1.19 0.97
43_I 63_Q 1.182 0.96
42_L 62_V 1.174 0.96
47_T 58_Q 1.162 0.96
39_C 67_K 1.141 0.95
28_A 40_A 1.126 0.95
35_K 51_Y 1.125 0.95
15_L 63_Q 1.11 0.94
77_L 81_K 1.106 0.94
105_S 109_A 1.106 0.94
41_T 46_A 1.101 0.94
15_L 41_T 1.091 0.94
37_A 40_A 1.088 0.94
46_A 63_Q 1.075 0.93
53_E 57_E 1.072 0.93
79_C 82_S 1.059 0.92
88_T 102_D 1.055 0.92
30_K 34_E 1.053 0.92
35_K 110_S 1.047 0.92
28_A 42_L 1.023 0.91
42_L 49_L 1.014 0.90
18_A 62_V 1.013 0.90
51_Y 110_S 1.01 0.90
11_S 96_V 1.001 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4e98A311000.064Contact Map0.895
2zfhA611000.071Contact Map0.934
3gsdA1211000.072Contact Map0.839
4iyqA311000.074Contact Map0.821
1naqA611000.079Contact Map0.745
1oscA611000.086Contact Map0.931
1kr4A10.99111000.088Contact Map0.61
2zomA30.99111000.091Contact Map0.818
2nuhA10.94641000.103Contact Map0.734
1nzaA10.91961000.105Contact Map0.682

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0149 seconds.