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CCME - Cytochrome c-type biogenesis protein CcmE
UniProt: P69490 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12055
Length: 159 (142)
Sequences: 556
Seq/Len: 3.92

CCME
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_M 83_T 2.868 1.00
79_K 96_E 2.867 1.00
42_E 47_K 2.591 1.00
84_I 109_V 2.338 1.00
67_M 90_S 2.265 1.00
112_Q 125_E 2.06 1.00
3_I 6_K 2.014 1.00
65_M 87_A 1.914 1.00
139_V 142_A 1.821 1.00
104_R 107_Q 1.776 0.99
43_I 60_L 1.721 0.99
83_T 90_S 1.662 0.99
140_E 144_E 1.621 0.99
25_L 29_A 1.568 0.98
144_E 147_H 1.554 0.98
60_L 121_I 1.51 0.98
93_V 109_V 1.506 0.98
116_E 120_H 1.487 0.97
30_L 34_I 1.437 0.96
99_L 126_V 1.435 0.96
94_S 120_H 1.402 0.96
116_E 122_L 1.396 0.96
72_Q 81_T 1.393 0.96
21_L 31_R 1.369 0.95
30_L 35_D 1.342 0.94
104_R 109_V 1.325 0.94
20_A 24_G 1.305 0.93
37_F 108_G 1.301 0.93
141_K 144_E 1.298 0.93
63_G 130_H 1.295 0.93
139_V 143_M 1.241 0.91
17_A 21_L 1.219 0.90
40_P 130_H 1.213 0.89
65_M 143_M 1.207 0.89
30_L 78_L 1.202 0.89
108_G 137_P 1.196 0.88
102_L 130_H 1.19 0.88
7_N 32_S 1.174 0.87
31_R 135_T 1.161 0.86
47_K 54_P 1.152 0.86
41_G 62_V 1.151 0.86
80_V 99_L 1.148 0.85
59_R 124_K 1.147 0.85
19_L 24_G 1.142 0.85
2_N 145_A 1.134 0.84
40_P 63_G 1.131 0.84
81_T 120_H 1.116 0.83
40_P 102_L 1.112 0.83
21_L 44_L 1.109 0.83
107_Q 133_N 1.094 0.81
36_L 112_Q 1.088 0.81
44_L 119_N 1.084 0.81
19_L 35_D 1.077 0.80
28_Y 36_L 1.073 0.80
74_D 77_S 1.072 0.80
116_E 119_N 1.07 0.79
1_M 5_R 1.069 0.79
30_L 36_L 1.067 0.79
102_L 132_E 1.065 0.79
41_G 45_Y 1.049 0.77
27_L 104_R 1.036 0.76
30_L 33_N 1.032 0.76
128_A 136_P 1.028 0.75
37_F 105_E 1.028 0.75
28_Y 35_D 1.023 0.75
41_G 88_E 1.018 0.74
81_T 92_D 1.015 0.74
29_A 126_V 1.013 0.74
63_G 132_E 1.011 0.74
40_P 131_D 1.01 0.74
79_K 94_S 1.008 0.73
138_E 142_A 1.006 0.73
2_N 39_T 1.006 0.73
93_V 137_P 1.003 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1sr3A10.81761000.255Contact Map0.506
1j6qA10.84281000.263Contact Map0.533
2kctA10.5661000.516Contact Map0.643
4hl0A20.459126.40.945Contact Map0.191
1n9wA20.666723.30.946Contact Map0.303
4gn4B10.528318.70.949Contact Map0.552
1o7iA20.679217.40.949Contact Map0.378
2lxjA10.396216.70.95Contact Map0.141
3camA20.396216.50.95Contact Map0.166
2xgtA20.666716.10.95Contact Map0.479

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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