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APT - Adenine phosphoribosyltransferase
UniProt: P69503 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10051
Length: 183 (174)
Sequences: 3914
Seq/Len: 22.49

APT
Paralog alert: 0.86 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: APT PYRE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
121_K 148_E 4.186 1.00
142_I 147_G 3.15 1.00
59_K 120_D 3.009 1.00
58_T 120_D 2.565 1.00
162_G 165_Q 2.449 1.00
159_F 179_P 2.338 1.00
164_E 168_E 2.338 1.00
46_D 77_G 2.228 1.00
117_K 120_D 2.194 1.00
94_E 113_V 2.136 1.00
99_T 108_Q 2.089 1.00
52_Y 123_L 2.046 1.00
157_N 164_E 2.033 1.00
71_G 82_F 1.968 1.00
98_E 140_K 1.952 1.00
98_E 144_R 1.931 1.00
50_E 53_K 1.907 1.00
42_A 77_G 1.894 1.00
121_K 150_A 1.845 1.00
136_E 140_K 1.837 1.00
101_D 106_T 1.819 1.00
51_R 175_Y 1.813 1.00
56_G 121_K 1.753 1.00
47_L 50_E 1.717 1.00
17_S 27_L 1.65 1.00
61_V 85_V 1.648 1.00
136_E 166_R 1.646 1.00
135_I 152_A 1.64 1.00
152_A 172_I 1.638 1.00
139_V 172_I 1.626 1.00
135_I 154_F 1.612 1.00
143_R 172_I 1.606 1.00
97_S 108_Q 1.556 1.00
85_V 138_T 1.531 1.00
16_K 93_R 1.526 1.00
165_Q 168_E 1.521 1.00
118_P 146_G 1.52 1.00
20_D 24_P 1.499 1.00
49_V 77_G 1.499 1.00
154_F 176_S 1.495 1.00
55_A 173_T 1.495 1.00
42_A 76_L 1.471 1.00
165_Q 169_K 1.465 1.00
57_I 80_V 1.462 1.00
140_K 143_R 1.454 1.00
42_A 79_G 1.441 1.00
61_V 142_I 1.432 1.00
52_Y 153_A 1.428 1.00
63_T 138_T 1.423 1.00
48_L 74_V 1.406 0.99
75_A 82_F 1.399 0.99
49_V 78_L 1.394 0.99
49_V 74_V 1.392 0.99
9_E 13_N 1.381 0.99
39_K 79_G 1.369 0.99
140_K 144_R 1.365 0.99
59_K 83_V 1.357 0.99
10_Y 43_L 1.335 0.99
139_V 152_A 1.332 0.99
99_T 106_T 1.309 0.99
9_E 12_K 1.305 0.99
48_L 153_A 1.299 0.99
14_S 37_D 1.291 0.99
157_N 179_P 1.286 0.99
143_R 148_E 1.282 0.99
17_S 29_R 1.266 0.99
140_K 170_Q 1.252 0.99
129_L 154_F 1.246 0.98
154_F 174_S 1.244 0.98
123_L 151_D 1.211 0.98
14_S 40_A 1.186 0.98
139_V 143_R 1.18 0.98
73_P 76_L 1.168 0.97
151_D 173_T 1.147 0.97
143_R 170_Q 1.145 0.97
32_T 112_H 1.138 0.97
156_I 180_F 1.135 0.97
96_I 145_L 1.125 0.97
41_Y 72_A 1.124 0.97
151_D 175_Y 1.123 0.97
58_T 119_G 1.119 0.96
61_V 138_T 1.116 0.96
34_L 44_S 1.106 0.96
176_S 179_P 1.085 0.96
43_L 46_D 1.085 0.96
19_Q 27_L 1.071 0.95
47_L 177_L 1.067 0.95
116_I 147_G 1.057 0.95
52_Y 57_I 1.056 0.95
93_R 112_H 1.041 0.94
124_V 138_T 1.04 0.94
56_G 80_V 1.039 0.94
128_L 156_I 1.038 0.94
97_S 110_E 1.033 0.94
149_V 172_I 1.028 0.94
119_G 148_E 1.019 0.93
49_V 53_K 1.005 0.93
166_R 169_K 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4m0kA40.96721000.267Contact Map0.835
4lzaA20.96721000.29Contact Map0.879
2dy0A211000.329Contact Map0.852
1qb7A111000.359Contact Map0.669
3qw4B20.90711000.378Contact Map0.682
1zn8A20.96721000.392Contact Map0.823
1g2qA20.97811000.396Contact Map0.774
1l1qA10.96721000.404Contact Map0.582
2wnsA20.89071000.41Contact Map0.769
3mjdA40.91261000.416Contact Map0.757

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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