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AMTB - Ammonia channel
UniProt: P69681 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11821
Length: 428 (402)
Sequences: 2644
Seq/Len: 6.58

AMTB
Paralog alert: 0.27 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
199_V 389_G 5.109 1.00
44_F 229_I 4.478 1.00
346_V 350_M 4.022 1.00
397_K 400_D 3.897 1.00
266_G 311_V 3.326 1.00
200_G 396_Y 3.211 1.00
301_I 309_I 3.041 1.00
84_Y 159_T 3.001 1.00
293_G 313_A 2.992 1.00
174_L 383_I 2.979 1.00
349_I 378_L 2.801 1.00
375_L 379_E 2.76 1.00
408_P 411_Q 2.754 1.00
345_I 381_I 2.75 1.00
121_I 250_A 2.744 1.00
272_W 278_P 2.702 1.00
227_T 284_C 2.557 1.00
312_V 346_V 2.522 1.00
235_F 257_V 2.444 1.00
75_A 264_I 2.426 1.00
320_G 342_V 2.389 1.00
239_A 253_F 2.349 1.00
105_L 123_V 2.295 1.00
168_M 174_L 2.279 1.00
393_F 397_K 2.277 1.00
350_M 353_I 2.275 1.00
83_V 104_M 2.272 1.00
317_G 343_C 2.247 1.00
397_K 401_L 2.245 1.00
203_L 393_F 2.205 1.00
264_I 287_A 2.201 1.00
264_I 283_A 2.148 1.00
180_A 380_S 2.145 1.00
39_T 124_A 2.144 1.00
187_T 348_C 2.05 1.00
90_F 122_H 2.04 1.00
316_A 346_V 2.032 1.00
161_S 391_V 1.992 1.00
294_V 301_I 1.986 1.00
141_L 145_I 1.974 1.00
251_L 255_N 1.972 1.00
208_V 409_E 1.94 1.00
262_A 307_L 1.918 1.00
165_I 192_N 1.889 1.00
152_I 403_V 1.842 1.00
80_L 155_V 1.824 1.00
378_L 382_A 1.807 1.00
79_I 307_L 1.805 1.00
78_C 127_G 1.767 1.00
38_C 240_G 1.748 1.00
77_V 158_L 1.739 1.00
407_V 416_L 1.727 1.00
57_L 281_L 1.712 1.00
168_M 383_I 1.708 1.00
223_V 284_C 1.705 1.00
70_V 138_V 1.703 1.00
72_V 151_L 1.699 1.00
349_I 374_L 1.687 1.00
181_L 299_G 1.682 1.00
89_A 166_A 1.681 1.00
270_G 315_L 1.679 1.00
165_I 384_T 1.676 1.00
258_V 307_L 1.674 1.00
293_G 309_I 1.663 1.00
34_F 37_I 1.637 1.00
80_L 159_T 1.635 1.00
387_W 391_V 1.578 1.00
123_V 254_V 1.57 0.99
224_F 280_L 1.559 0.99
88_L 97_F 1.556 0.99
102_W 119_Q 1.532 0.99
196_A 388_S 1.531 0.99
78_C 261_A 1.524 0.99
78_C 257_V 1.511 0.99
80_L 163_I 1.507 0.99
134_V 154_V 1.505 0.99
288_I 339_V 1.496 0.99
320_G 338_G 1.495 0.99
191_I 195_I 1.482 0.99
178_H 379_E 1.479 0.99
194_A 341_G 1.473 0.99
32_N 121_I 1.467 0.99
82_V 258_V 1.457 0.99
219_N 222_M 1.451 0.99
201_A 330_V 1.448 0.99
203_L 397_K 1.448 0.99
390_V 394_I 1.443 0.99
218_H 426_Y 1.442 0.99
141_L 200_G 1.433 0.99
195_I 389_G 1.423 0.99
152_I 399_A 1.42 0.99
79_I 265_L 1.406 0.99
146_R 404_G 1.398 0.99
181_L 300_Y 1.386 0.98
68_T 283_A 1.373 0.98
220_L 281_L 1.355 0.98
375_L 378_L 1.355 0.98
195_I 199_V 1.352 0.98
346_V 353_I 1.347 0.98
34_F 38_C 1.337 0.98
379_E 383_I 1.325 0.98
376_V 379_E 1.325 0.98
156_V 395_G 1.324 0.98
65_S 69_Q 1.319 0.98
73_T 150_V 1.319 0.98
178_H 376_V 1.319 0.98
175_L 380_S 1.318 0.98
312_V 316_A 1.301 0.97
352_G 377_Q 1.285 0.97
400_D 404_G 1.284 0.97
136_L 336_V 1.283 0.97
367_G 370_M 1.281 0.97
411_Q 419_N 1.276 0.97
149_A 399_A 1.271 0.97
79_I 262_A 1.267 0.97
251_L 303_V 1.266 0.97
140_A 197_G 1.265 0.97
74_F 131_C 1.258 0.97
86_Y 119_Q 1.247 0.96
258_V 303_V 1.239 0.96
43_L 74_F 1.236 0.96
309_I 354_F 1.235 0.96
399_A 402_T 1.228 0.96
309_I 350_M 1.227 0.96
69_Q 138_V 1.223 0.96
43_L 232_I 1.222 0.96
196_A 392_A 1.22 0.96
156_V 160_L 1.217 0.96
330_V 338_G 1.216 0.96
409_E 413_R 1.214 0.96
40_A 232_I 1.209 0.95
117_I 243_G 1.205 0.95
169_V 188_V 1.204 0.95
145_I 405_L 1.195 0.95
209_G 215_F 1.193 0.95
40_A 253_F 1.188 0.95
30_A 33_A 1.179 0.95
199_V 393_F 1.173 0.94
90_F 126_Q 1.173 0.94
399_A 403_V 1.169 0.94
82_V 307_L 1.169 0.94
62_N 416_L 1.164 0.94
65_S 421_H 1.159 0.94
169_V 384_T 1.157 0.94
31_D 246_N 1.154 0.94
371_G 375_L 1.144 0.93
146_R 149_A 1.143 0.93
59_R 143_E 1.141 0.93
76_L 151_L 1.139 0.93
411_Q 420_S 1.139 0.93
187_T 384_T 1.139 0.93
389_G 393_F 1.134 0.93
302_G 356_A 1.134 0.93
242_A 249_A 1.132 0.93
175_L 180_A 1.126 0.93
159_T 163_I 1.12 0.92
372_H 376_V 1.12 0.92
406_R 412_E 1.115 0.92
192_N 388_S 1.113 0.92
208_V 413_R 1.11 0.92
165_I 387_W 1.104 0.92
41_L 236_G 1.102 0.92
31_D 116_S 1.101 0.92
386_V 390_V 1.101 0.92
28_D 31_D 1.099 0.91
364_F 368_V 1.095 0.91
195_I 385_I 1.094 0.91
315_L 319_W 1.09 0.91
35_M 117_I 1.089 0.91
398_L 401_L 1.087 0.91
345_I 349_I 1.085 0.91
35_M 121_I 1.085 0.91
39_T 121_I 1.084 0.91
272_W 276_G 1.081 0.91
320_G 324_L 1.078 0.90
304_G 308_I 1.061 0.89
174_L 379_E 1.059 0.89
120_Y 250_A 1.059 0.89
48_P 225_T 1.058 0.89
252_A 298_C 1.056 0.89
122_H 243_G 1.051 0.89
270_G 319_W 1.046 0.89
260_T 263_A 1.046 0.89
80_L 84_Y 1.046 0.89
32_N 118_Y 1.043 0.88
160_L 391_V 1.039 0.88
180_A 348_C 1.033 0.88
337_F 341_G 1.032 0.88
55_G 63_V 1.03 0.88
187_T 191_I 1.03 0.88
385_I 389_G 1.03 0.88
285_S 339_V 1.029 0.87
190_H 193_A 1.028 0.87
266_G 314_G 1.026 0.87
158_L 163_I 1.025 0.87
242_A 246_N 1.024 0.87
409_E 412_E 1.023 0.87
63_V 67_L 1.021 0.87
300_Y 355_A 1.018 0.87
341_G 385_I 1.017 0.87
43_L 128_S 1.013 0.86
265_L 269_F 1.009 0.86
202_Y 389_G 1.007 0.86
138_V 150_V 1.003 0.86
76_L 155_V 1 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2b2hA10.91121000.065Contact Map0.777
1u7gA10.89951000.109Contact Map0.764
3b9wA10.84351000.32Contact Map0.503
3hd6A10.92991000.323Contact Map0.538
4apsA20.48137.50.981Contact Map0.176
1pw4A10.4936.80.981Contact Map0.118
2xutA30.48364.70.983Contact Map0.112
4g1uA20.49774.30.983Contact Map0.133
3wdoA10.47664.30.983Contact Map0.194
2gfpA20.443940.983Contact Map0.258

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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