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POTA - Spermidine/putrescine import ATP-binding protein PotA
UniProt: P69874 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10749
Length: 378 (360)
Sequences: 8992
Seq/Len: 24.98

POTA
Paralog alert: 0.82 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
230_G 234_E 4.696 1.00
47_T 215_S 4.42 1.00
133_R 138_E 4.26 1.00
44_E 217_R 3.906 1.00
73_R 80_D 3.844 1.00
227_E 241_N 3.765 1.00
315_G 331_V 3.511 1.00
19_Q 39_T 3.417 1.00
21_A 73_R 3.249 1.00
125_T 129_M 3.233 1.00
120_P 123_E 3.119 1.00
318_R 332_E 2.975 1.00
22_G 35_Q 2.913 1.00
140_F 143_R 2.813 1.00
34_P 225_R 2.772 1.00
107_F 142_Q 2.761 1.00
22_G 37_D 2.648 1.00
107_F 111_A 2.633 1.00
127_R 165_K 2.59 1.00
107_F 129_M 2.589 1.00
77_D 167_R 2.543 1.00
192_A 196_K 2.519 1.00
62_L 74_I 2.491 1.00
231_T 234_E 2.478 1.00
219_V 226_I 2.47 1.00
107_F 128_V 2.467 1.00
314_I 359_K 2.458 1.00
316_Y 359_K 2.457 1.00
132_L 141_A 2.446 1.00
131_A 163_V 2.439 1.00
46_L 219_V 2.438 1.00
76_L 81_I 2.353 1.00
63_I 202_V 2.342 1.00
107_F 125_T 2.34 1.00
79_E 167_R 2.328 1.00
33_I 62_L 2.267 1.00
18_V 168_L 2.211 1.00
31_E 34_P 2.13 1.00
19_Q 75_M 2.121 1.00
222_R 227_E 2.115 1.00
219_V 229_D 2.111 1.00
111_A 128_V 2.087 1.00
90_Y 167_R 2.077 1.00
41_N 44_E 2.076 1.00
20_L 23_I 2.066 1.00
355_S 358_Q 2.021 1.00
242_L 291_H 1.979 1.00
24_R 35_Q 1.961 1.00
316_Y 332_E 1.951 1.00
108_E 115_R 1.948 1.00
75_M 80_D 1.93 1.00
171_L 201_F 1.917 1.00
126_P 130_E 1.906 1.00
314_I 361_A 1.905 1.00
61_R 67_E 1.886 1.00
20_L 63_I 1.875 1.00
136_Q 185_Q 1.86 1.00
24_R 31_E 1.85 1.00
26_C 31_E 1.85 1.00
21_A 75_M 1.826 1.00
24_R 71_S 1.812 1.00
123_E 126_P 1.804 1.00
111_A 124_I 1.774 1.00
220_V 244_V 1.743 1.00
25_K 62_L 1.741 1.00
124_I 128_V 1.736 1.00
79_E 84_V 1.732 1.00
236_Y 297_E 1.724 1.00
135_V 159_A 1.711 1.00
105_T 108_E 1.682 1.00
122_A 126_P 1.681 1.00
257_T 289_K 1.674 1.00
110_V 159_A 1.674 1.00
25_K 67_E 1.672 1.00
242_L 253_M 1.66 1.00
242_L 246_G 1.649 1.00
33_I 59_V 1.643 1.00
46_L 229_D 1.634 1.00
251_I 293_L 1.616 1.00
62_L 69_V 1.612 1.00
119_T 123_E 1.608 1.00
101_F 113_G 1.586 1.00
119_T 124_I 1.575 1.00
20_L 38_L 1.563 1.00
81_I 84_V 1.561 1.00
246_G 253_M 1.56 1.00
331_V 362_I 1.526 1.00
113_G 164_N 1.524 1.00
46_L 217_R 1.507 1.00
85_P 88_N 1.505 1.00
130_E 165_K 1.496 1.00
25_K 70_D 1.495 1.00
129_M 141_A 1.49 1.00
253_M 291_H 1.488 1.00
54_C 221_M 1.482 1.00
127_R 130_E 1.479 1.00
105_T 144_K 1.461 1.00
255_N 289_K 1.447 1.00
75_M 78_N 1.44 1.00
123_E 127_R 1.438 1.00
115_R 121_A 1.434 1.00
36_L 59_V 1.424 1.00
41_N 217_R 1.42 1.00
130_E 133_R 1.418 1.00
298_D 368_W 1.414 1.00
131_A 162_V 1.41 1.00
234_E 238_E 1.395 0.99
26_C 71_S 1.39 0.99
69_V 74_I 1.388 0.99
38_L 219_V 1.383 0.99
110_V 132_L 1.373 0.99
20_L 59_V 1.352 0.99
320_R 329_S 1.35 0.99
73_R 82_T 1.348 0.99
194_Q 199_I 1.338 0.99
256_A 290_L 1.338 0.99
19_Q 78_N 1.314 0.99
129_M 133_R 1.311 0.99
233_R 237_E 1.304 0.99
191_K 214_M 1.3 0.99
194_Q 201_F 1.299 0.99
38_L 229_D 1.297 0.99
112_F 116_M 1.29 0.99
121_A 125_T 1.283 0.99
222_R 243_F 1.275 0.99
69_V 82_T 1.273 0.99
129_M 138_E 1.272 0.99
175_L 190_L 1.267 0.99
33_I 36_L 1.266 0.99
300_R 363_N 1.265 0.99
165_K 196_K 1.239 0.98
92_N 164_N 1.235 0.98
80_D 83_H 1.226 0.98
26_C 32_V 1.221 0.98
317_V 329_S 1.207 0.98
48_L 219_V 1.198 0.98
21_A 37_D 1.194 0.98
45_F 194_Q 1.184 0.98
24_R 34_P 1.184 0.98
45_F 214_M 1.179 0.98
255_N 291_H 1.174 0.98
326_T 342_S 1.164 0.97
22_G 71_S 1.162 0.97
23_I 62_L 1.149 0.97
217_R 229_D 1.143 0.97
237_E 322_Y 1.136 0.97
23_I 69_V 1.135 0.97
175_L 203_F 1.128 0.97
299_L 364_W 1.125 0.97
130_E 196_K 1.121 0.97
42_N 77_D 1.12 0.96
98_Y 177_A 1.115 0.96
228_Q 244_V 1.112 0.96
302_E 361_A 1.095 0.96
84_V 88_N 1.095 0.96
315_G 360_M 1.094 0.96
238_E 370_V 1.093 0.96
365_V 368_W 1.092 0.96
110_V 131_A 1.078 0.95
181_K 246_G 1.07 0.95
230_G 235_I 1.068 0.95
294_L 299_L 1.053 0.95
136_Q 189_E 1.053 0.95
74_I 81_I 1.051 0.94
108_E 111_A 1.05 0.94
26_C 70_D 1.047 0.94
59_V 221_M 1.038 0.94
315_G 333_L 1.026 0.94
220_V 235_I 1.018 0.93
191_K 195_R 1.015 0.93
132_L 137_L 1.011 0.93
300_R 365_V 1.007 0.93
208_Q 247_F 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2it1A20.92061000.256Contact Map0.867
1oxxK10.90481000.256Contact Map0.736
1v43A10.95241000.261Contact Map0.845
3rlfA20.93921000.263Contact Map0.827
3d31A20.9181000.264Contact Map0.738
2yyzA10.93391000.267Contact Map0.785
3fvqA20.92331000.269Contact Map0.75
1g29120.93121000.269Contact Map0.88
1z47A20.93651000.303Contact Map0.844
3gd7A40.94181000.364Contact Map0.709

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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