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ALLP - Putative allantoin permease
UniProt: P75712 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13618
Length: 484 (464)
Sequences: 2025
Seq/Len: 4.36

ALLP
Paralog alert: 0.65 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ALLP CODB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
404_N 407_E 4.772 1.00
393_A 462_F 4.563 1.00
84_G 248_S 3.539 1.00
393_A 466_A 3.515 1.00
397_V 462_F 2.943 1.00
63_M 277_V 2.822 1.00
432_V 464_A 2.818 1.00
229_F 233_I 2.695 1.00
433_A 464_A 2.601 1.00
433_A 461_A 2.523 1.00
429_V 468_L 2.447 1.00
22_Q 256_S 2.373 1.00
39_S 328_G 2.357 1.00
424_L 428_S 2.342 1.00
389_G 393_A 2.337 1.00
72_F 237_V 2.22 1.00
427_F 431_L 2.192 1.00
429_V 464_A 2.107 1.00
25_R 88_G 2.039 1.00
459_I 462_F 2.006 1.00
429_V 433_A 1.998 1.00
433_A 460_V 1.903 1.00
437_S 457_G 1.89 1.00
397_V 466_A 1.863 1.00
436_L 460_V 1.822 1.00
58_S 61_S 1.802 1.00
65_A 229_F 1.793 1.00
394_H 399_M 1.778 1.00
68_L 233_I 1.776 1.00
459_I 463_A 1.759 1.00
124_C 169_N 1.756 0.99
200_I 204_S 1.74 0.99
119_W 122_L 1.725 0.99
167_L 171_G 1.693 0.99
175_G 179_V 1.684 0.99
98_S 394_H 1.679 0.99
86_K 257_F 1.655 0.99
21_T 24_Q 1.604 0.99
81_G 251_T 1.601 0.99
15_E 24_Q 1.59 0.99
258_R 262_L 1.587 0.99
97_A 403_I 1.569 0.99
21_T 25_R 1.564 0.99
346_T 349_N 1.563 0.99
253_N 335_Y 1.547 0.98
390_V 426_A 1.546 0.98
120_F 325_N 1.545 0.98
53_F 62_I 1.54 0.98
392_M 396_F 1.531 0.98
428_S 468_L 1.529 0.98
229_F 232_V 1.526 0.98
442_F 446_M 1.519 0.98
120_F 358_S 1.511 0.98
460_V 464_A 1.511 0.98
389_G 458_V 1.49 0.98
83_A 94_I 1.488 0.98
390_V 429_V 1.473 0.98
426_A 465_Y 1.468 0.98
199_A 274_L 1.465 0.98
96_R 104_A 1.432 0.97
255_H 259_E 1.43 0.97
123_Q 329_N 1.43 0.97
233_I 237_V 1.43 0.97
15_E 18_L 1.419 0.97
57_L 65_A 1.411 0.97
52_F 232_V 1.403 0.97
184_T 187_L 1.397 0.96
292_A 303_R 1.395 0.96
357_I 361_I 1.386 0.96
463_A 466_A 1.376 0.96
262_L 266_L 1.374 0.96
96_R 394_H 1.367 0.96
345_L 353_I 1.363 0.96
78_V 265_T 1.361 0.96
50_G 84_G 1.357 0.96
398_V 466_A 1.341 0.95
463_A 467_L 1.338 0.95
28_K 31_N 1.337 0.95
344_K 349_N 1.335 0.95
299_D 302_Q 1.332 0.95
125_Y 128_S 1.328 0.95
99_Y 426_A 1.319 0.95
149_F 152_L 1.311 0.94
325_N 329_N 1.309 0.94
40_V 271_A 1.309 0.94
268_L 272_Y 1.304 0.94
160_I 163_L 1.303 0.94
425_T 469_K 1.299 0.94
193_I 197_G 1.298 0.94
199_A 278_A 1.297 0.94
227_F 400_R 1.293 0.94
434_V 437_S 1.288 0.94
345_L 350_G 1.287 0.94
432_V 460_V 1.286 0.94
74_A 78_V 1.285 0.94
187_L 192_Y 1.266 0.93
296_N 299_D 1.263 0.93
266_L 428_S 1.261 0.93
240_W 243_P 1.26 0.93
64_L 229_F 1.259 0.93
464_A 468_L 1.257 0.93
425_T 429_V 1.255 0.93
455_F 459_I 1.255 0.93
167_L 432_V 1.252 0.93
422_F 427_F 1.249 0.92
128_S 161_T 1.246 0.92
118_M 376_F 1.238 0.92
94_I 248_S 1.233 0.92
118_M 377_L 1.226 0.91
52_F 62_I 1.223 0.91
169_N 325_N 1.213 0.91
66_I 276_A 1.21 0.91
82_A 86_K 1.206 0.91
198_M 304_W 1.204 0.90
156_L 164_I 1.2 0.90
259_E 262_L 1.199 0.90
320_T 324_T 1.195 0.90
29_T 259_E 1.19 0.90
426_A 429_V 1.184 0.89
71_F 390_V 1.183 0.89
177_G 181_N 1.181 0.89
386_P 457_G 1.177 0.89
250_F 272_Y 1.176 0.89
66_I 70_A 1.172 0.89
460_V 463_A 1.167 0.89
462_F 465_Y 1.166 0.88
230_L 234_N 1.162 0.88
256_S 259_E 1.156 0.88
166_W 359_L 1.141 0.87
87_Y 403_I 1.138 0.87
349_N 352_L 1.138 0.87
202_A 298_L 1.133 0.87
58_S 81_G 1.133 0.87
189_P 192_Y 1.131 0.86
79_L 396_F 1.128 0.86
53_F 283_I 1.123 0.86
258_R 400_R 1.121 0.86
394_H 398_V 1.12 0.86
429_V 461_A 1.12 0.86
33_F 266_L 1.116 0.85
433_A 436_L 1.115 0.85
390_V 430_T 1.114 0.85
72_F 233_I 1.113 0.85
106_F 432_V 1.112 0.85
36_W 92_A 1.11 0.85
431_L 464_A 1.107 0.85
99_Y 103_G 1.105 0.85
81_G 260_Q 1.103 0.84
102_R 105_L 1.103 0.84
120_F 123_Q 1.103 0.84
252_Q 394_H 1.102 0.84
160_I 164_I 1.102 0.84
82_A 396_F 1.101 0.84
362_C 365_K 1.1 0.84
84_G 251_T 1.096 0.84
393_A 397_V 1.093 0.84
44_P 122_L 1.093 0.84
120_F 329_N 1.092 0.84
377_L 399_M 1.091 0.84
172_I 322_I 1.091 0.84
43_V 123_Q 1.09 0.83
250_F 332_P 1.081 0.83
70_A 276_A 1.08 0.83
441_K 444_H 1.08 0.83
129_L 296_N 1.078 0.83
407_E 411_A 1.077 0.82
397_V 463_A 1.076 0.82
229_F 236_V 1.075 0.82
121_G 358_S 1.071 0.82
352_L 356_I 1.07 0.82
259_E 263_G 1.07 0.82
114_I 200_I 1.066 0.82
237_V 241_A 1.063 0.81
162_F 166_W 1.063 0.81
466_A 470_K 1.06 0.81
428_S 431_L 1.06 0.81
278_A 460_V 1.059 0.81
428_S 432_V 1.058 0.81
463_A 471_R 1.057 0.81
267_G 271_A 1.05 0.80
64_L 68_L 1.049 0.80
213_D 357_I 1.049 0.80
17_L 96_R 1.046 0.80
39_S 248_S 1.045 0.80
45_N 123_Q 1.043 0.80
93_M 96_R 1.042 0.80
436_L 456_V 1.041 0.79
37_M 456_V 1.04 0.79
123_Q 321_T 1.038 0.79
69_S 233_I 1.037 0.79
116_A 246_S 1.034 0.79
76_V 244_A 1.031 0.79
95_L 387_V 1.03 0.78
209_G 213_D 1.029 0.78
435_I 439_G 1.027 0.78
85_S 254_A 1.025 0.78
65_A 69_S 1.025 0.78
120_F 330_I 1.023 0.78
91_F 111_R 1.023 0.78
248_S 251_T 1.02 0.77
164_I 258_R 1.019 0.77
80_N 391_M 1.017 0.77
117_I 357_I 1.015 0.77
203_I 208_I 1.011 0.77
127_G 165_F 1.009 0.76
297_V 301_V 1.003 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jlnA10.91321000.182Contact Map0.617
3l1lA10.87499.20.872Contact Map0.449
3dh4A40.886498.70.895Contact Map0.518
2xq2A10.896798.60.897Contact Map0.57
3giaA10.855498.60.898Contact Map0.396
4djkA20.902998.30.907Contact Map0.45
2a65A10.886495.30.94Contact Map0.442
4m48A10.8988570.963Contact Map0.341
2wswA10.723156.30.963Contact Map0.299
4ainA30.7562510.964Contact Map0.413

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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