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CHIP - Chitoporin
UniProt: P75733 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13659
Length: 468 (403)
Sequences: 740
Seq/Len: 1.84

CHIP
Paralog alert: 0.23 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
143_G 181_D 3.849 1.00
291_A 317_A 3.363 1.00
149_A 174_A 3.362 1.00
299_G 307_D 3.181 1.00
34_G 37_D 2.955 1.00
429_L 457_V 2.882 1.00
133_L 199_K 2.607 1.00
98_E 129_S 2.6 1.00
39_S 78_F 2.599 1.00
194_W 222_H 2.497 1.00
363_Y 368_W 2.382 1.00
345_N 356_A 2.352 1.00
96_A 166_F 2.287 1.00
190_F 226_A 2.093 0.99
304_D 367_N 2.075 0.99
305_V 361_A 2.074 0.99
416_T 426_M 2.034 0.99
68_S 114_S 2.033 0.99
238_A 250_Y 2.017 0.99
427_F 459_F 1.982 0.99
41_L 78_F 1.92 0.98
188_L 228_Y 1.919 0.98
427_F 461_V 1.917 0.98
240_F 250_Y 1.882 0.98
82_Y 146_W 1.88 0.98
267_T 298_F 1.863 0.98
230_F 236_L 1.861 0.98
248_D 277_K 1.849 0.98
237_E 253_K 1.839 0.97
236_L 254_A 1.801 0.97
355_K 384_D 1.799 0.97
50_R 456_D 1.797 0.97
34_G 84_A 1.778 0.97
178_A 181_D 1.758 0.96
145_V 178_A 1.74 0.96
188_L 226_A 1.738 0.96
258_F 267_T 1.698 0.95
45_I 69_H 1.694 0.95
53_D 455_R 1.676 0.95
95_T 132_S 1.642 0.94
283_V 321_Q 1.64 0.94
238_A 252_A 1.62 0.94
257_K 264_P 1.613 0.94
147_A 176_A 1.607 0.93
94_F 168_P 1.582 0.93
355_K 383_W 1.574 0.92
291_A 343_W 1.55 0.92
365_L 413_A 1.536 0.91
324_F 348_D 1.53 0.91
153_Q 161_A 1.528 0.91
242_Q 277_K 1.527 0.91
429_L 459_F 1.515 0.90
172_Q 196_N 1.511 0.90
175_E 223_S 1.509 0.90
158_T 161_A 1.472 0.89
101_E 105_S 1.472 0.89
152_I 175_E 1.462 0.88
377_A 411_L 1.461 0.88
234_F 256_Y 1.434 0.87
41_L 467_I 1.429 0.87
316_K 355_K 1.428 0.87
425_T 463_A 1.421 0.86
32_A 37_D 1.418 0.86
312_G 316_K 1.403 0.85
297_T 309_R 1.403 0.85
143_G 178_A 1.402 0.85
349_F 408_A 1.394 0.85
185_A 188_L 1.392 0.85
45_I 465_F 1.379 0.84
80_S 90_D 1.379 0.84
371_P 418_Q 1.353 0.82
363_Y 367_N 1.351 0.82
417_I 422_A 1.342 0.82
410_S 432_T 1.342 0.82
352_N 386_K 1.337 0.81
431_F 457_V 1.337 0.81
364_D 372_G 1.336 0.81
194_W 220_Y 1.334 0.81
422_A 427_F 1.327 0.81
360_G 378_S 1.324 0.80
73_N 96_A 1.323 0.80
313_T 356_A 1.321 0.80
47_Y 65_T 1.318 0.80
361_A 377_A 1.317 0.80
406_E 434_Y 1.313 0.80
192_Y 226_A 1.309 0.79
193_M 223_S 1.302 0.79
356_A 380_V 1.297 0.78
218_V 246_Y 1.294 0.78
362_M 376_G 1.293 0.78
69_H 74_A 1.29 0.78
257_K 266_T 1.288 0.78
80_S 139_K 1.275 0.77
159_L 195_T 1.273 0.77
94_F 133_L 1.273 0.77
256_Y 267_T 1.269 0.76
118_K 128_K 1.262 0.76
414_V 426_M 1.251 0.75
409_Y 431_F 1.251 0.75
44_G 75_N 1.25 0.75
149_A 172_Q 1.247 0.75
374_A 414_V 1.242 0.74
43_G 190_F 1.23 0.73
87_F 142_Y 1.227 0.73
305_V 377_A 1.226 0.73
49_Q 63_Y 1.223 0.72
378_S 412_D 1.223 0.72
82_Y 148_R 1.219 0.72
360_G 376_G 1.217 0.72
417_I 427_F 1.213 0.72
51_E 55_K 1.212 0.71
91_I 136_A 1.21 0.71
299_G 309_R 1.208 0.71
66_N 113_F 1.207 0.71
144_P 181_D 1.196 0.70
256_Y 298_F 1.19 0.69
226_A 238_A 1.186 0.69
412_D 428_K 1.174 0.68
93_A 134_Y 1.172 0.68
116_S 126_G 1.165 0.67
37_D 84_A 1.164 0.67
233_N 259_D 1.162 0.67
433_E 455_R 1.161 0.67
343_W 350_N 1.16 0.67
197_E 208_E 1.152 0.66
208_E 219_D 1.15 0.66
381_Y 405_E 1.14 0.65
273_G 290_T 1.137 0.64
271_F 290_T 1.135 0.64
185_A 190_F 1.133 0.64
322_G 434_Y 1.132 0.64
65_T 105_S 1.129 0.64
46_Y 460_M 1.127 0.63
242_Q 248_D 1.126 0.63
374_A 416_T 1.122 0.63
68_S 166_F 1.122 0.63
432_T 456_D 1.12 0.63
140_F 257_K 1.117 0.62
357_V 381_Y 1.116 0.62
196_N 219_D 1.111 0.62
100_A 104_D 1.111 0.62
362_M 378_S 1.106 0.61
345_N 358_F 1.103 0.61
187_A 226_A 1.102 0.61
266_T 299_G 1.101 0.61
435_D 455_R 1.095 0.60
310_L 359_F 1.094 0.60
357_V 383_W 1.092 0.60
45_I 97_I 1.091 0.60
370_L 405_E 1.088 0.59
181_D 185_A 1.082 0.59
263_S 300_Y 1.078 0.58
117_N 128_K 1.076 0.58
419_D 425_T 1.075 0.58
45_I 74_A 1.072 0.58
38_D 81_G 1.072 0.58
94_F 432_T 1.065 0.57
188_L 230_F 1.064 0.57
135_K 305_V 1.063 0.57
149_A 196_N 1.061 0.56
87_F 140_F 1.056 0.56
159_L 325_L 1.055 0.56
227_K 235_V 1.052 0.55
158_T 223_S 1.049 0.55
82_Y 141_K 1.049 0.55
304_D 363_Y 1.047 0.55
269_Y 292_W 1.045 0.55
66_N 409_Y 1.045 0.55
353_G 386_K 1.044 0.55
90_D 139_K 1.041 0.54
69_H 114_S 1.039 0.54
118_K 125_S 1.035 0.54
93_A 241_G 1.035 0.54
276_D 280_D 1.033 0.53
243_A 247_I 1.032 0.53
161_A 171_Y 1.028 0.53
405_E 437_H 1.027 0.53
304_D 368_W 1.027 0.53
382_A 406_E 1.023 0.52
114_S 131_I 1.02 0.52
222_H 244_E 1.02 0.52
172_Q 244_E 1.017 0.52
86_M 148_R 1.017 0.52
192_Y 196_N 1.016 0.52
186_G 231_K 1.016 0.52
199_K 206_M 1.007 0.51
113_F 131_I 1.006 0.50
305_V 308_L 1.004 0.50
103_G 125_S 1.003 0.50
170_T 245_G 1.001 0.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3sybA10.90381000.254Contact Map0.708
3sy7A10.85681000.276Contact Map0.746
4frxA20.83971000.277Contact Map0.735
4frtA20.8121000.288Contact Map0.723
4fspA10.82911000.294Contact Map0.671
3sy9A40.84191000.296Contact Map0.684
3szdB20.82051000.296Contact Map0.718
3t24A30.81411000.301Contact Map0.777
2y0lA10.82481000.303Contact Map0.727
4ft6A10.81411000.305Contact Map0.701

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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