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ABRB - Protein AbrB
UniProt: P75747 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13310
Length: 348 (339)
Sequences: 489
Seq/Len: 1.44

ABRB
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
300_L 325_L 1.934 0.97
66_A 214_G 1.912 0.97
129_A 139_V 1.898 0.97
147_V 151_A 1.88 0.97
83_I 320_M 1.787 0.95
6_W 9_L 1.765 0.95
197_G 202_L 1.748 0.94
124_A 236_Y 1.726 0.94
27_A 302_T 1.716 0.93
19_G 22_A 1.655 0.92
109_P 133_G 1.652 0.92
236_Y 305_V 1.629 0.91
62_G 207_M 1.625 0.91
236_Y 302_T 1.602 0.90
216_V 220_G 1.593 0.90
17_S 317_I 1.572 0.89
195_T 199_L 1.547 0.88
30_L 150_V 1.494 0.85
7_G 86_A 1.481 0.84
42_M 148_L 1.479 0.84
262_I 317_I 1.469 0.84
17_S 29_L 1.417 0.81
12_L 25_L 1.405 0.80
36_A 40_F 1.396 0.79
275_G 279_G 1.387 0.79
31_L 130_Q 1.37 0.77
57_A 294_A 1.364 0.77
104_R 337_R 1.357 0.76
286_I 291_A 1.355 0.76
236_Y 301_D 1.354 0.76
116_G 124_A 1.348 0.76
85_L 326_F 1.344 0.75
327_S 330_L 1.341 0.75
61_L 84_V 1.335 0.75
263_L 267_F 1.319 0.74
74_L 275_G 1.318 0.73
250_Q 321_Q 1.316 0.73
193_A 213_A 1.311 0.73
94_S 123_A 1.308 0.73
109_P 288_F 1.305 0.72
113_G 128_M 1.303 0.72
17_S 119_P 1.296 0.72
193_A 209_I 1.293 0.71
211_M 267_F 1.291 0.71
116_G 154_A 1.286 0.71
338_F 342_Y 1.285 0.71
70_T 119_P 1.276 0.70
13_S 16_L 1.273 0.70
28_A 236_Y 1.272 0.70
17_S 194_G 1.269 0.69
147_V 274_A 1.267 0.69
38_I 151_A 1.267 0.69
115_W 305_V 1.267 0.69
12_L 39_I 1.264 0.69
184_L 188_L 1.264 0.69
98_V 265_S 1.261 0.69
124_A 302_T 1.255 0.68
302_T 305_V 1.254 0.68
125_M 328_I 1.252 0.68
112_T 121_G 1.245 0.67
277_A 288_F 1.242 0.67
56_A 271_A 1.236 0.66
257_R 307_A 1.235 0.66
116_G 142_M 1.234 0.66
102_L 305_V 1.233 0.66
12_L 35_I 1.228 0.66
10_C 242_R 1.22 0.65
13_S 33_P 1.219 0.65
104_R 219_S 1.217 0.65
144_Y 296_S 1.203 0.63
276_M 328_I 1.192 0.62
143_Q 291_A 1.191 0.62
122_A 296_S 1.19 0.62
61_L 79_V 1.189 0.62
235_A 269_L 1.18 0.61
253_L 257_R 1.172 0.60
91_T 204_S 1.166 0.60
142_M 147_V 1.166 0.60
64_M 150_V 1.16 0.59
149_F 263_L 1.16 0.59
295_T 320_M 1.155 0.59
184_L 234_M 1.152 0.58
89_L 268_A 1.152 0.58
144_Y 292_Y 1.15 0.58
121_G 301_D 1.149 0.58
303_V 310_S 1.147 0.58
86_A 187_I 1.139 0.57
227_L 230_W 1.139 0.57
287_D 290_T 1.138 0.57
308_A 321_Q 1.134 0.57
199_L 264_L 1.131 0.56
63_C 210_P 1.13 0.56
303_V 317_I 1.129 0.56
18_I 234_M 1.128 0.56
63_C 202_L 1.127 0.56
97_I 267_F 1.126 0.56
140_A 312_A 1.12 0.55
20_F 322_T 1.117 0.55
250_Q 264_L 1.112 0.54
122_A 273_C 1.112 0.54
141_F 145_L 1.11 0.54
318_M 335_I 1.108 0.54
32_G 36_A 1.108 0.54
132_Y 139_V 1.105 0.54
23_V 234_M 1.103 0.53
143_Q 236_Y 1.102 0.53
118_S 328_I 1.101 0.53
81_W 121_G 1.099 0.53
77_L 84_V 1.097 0.53
26_P 240_G 1.095 0.53
27_A 129_A 1.091 0.52
9_L 37_G 1.088 0.52
23_V 59_A 1.085 0.52
184_L 219_S 1.084 0.52
124_A 301_D 1.081 0.51
115_W 336_A 1.08 0.51
125_M 296_S 1.08 0.51
84_V 92_L 1.079 0.51
267_F 285_H 1.077 0.51
62_G 120_G 1.074 0.50
121_G 236_Y 1.073 0.50
13_S 241_W 1.072 0.50
260_P 303_V 1.07 0.50
128_M 134_A 1.069 0.50
125_M 329_L 1.068 0.50
125_M 332_G 1.068 0.50
36_A 226_E 1.066 0.50
332_G 336_A 1.066 0.50
69_L 154_A 1.065 0.50
36_A 300_L 1.064 0.49
37_G 144_Y 1.064 0.49
26_P 228_P 1.062 0.49
85_L 157_V 1.061 0.49
127_A 157_V 1.057 0.49
50_P 143_Q 1.056 0.49
23_V 188_L 1.056 0.49
15_L 282_R 1.054 0.48
95_S 125_M 1.052 0.48
271_A 275_G 1.051 0.48
214_G 218_Q 1.051 0.48
134_A 139_V 1.05 0.48
155_V 310_S 1.049 0.48
147_V 308_A 1.044 0.47
102_L 148_L 1.043 0.47
29_L 302_T 1.043 0.47
150_V 298_G 1.04 0.47
140_A 247_F 1.036 0.47
115_W 301_D 1.035 0.46
27_A 301_D 1.034 0.46
125_M 150_V 1.033 0.46
123_A 305_V 1.032 0.46
210_P 292_Y 1.028 0.46
27_A 236_Y 1.027 0.46
145_L 255_A 1.026 0.46
60_I 234_M 1.026 0.46
68_N 314_M 1.025 0.45
10_C 156_L 1.022 0.45
25_L 60_I 1.021 0.45
23_V 74_L 1.02 0.45
44_G 247_F 1.02 0.45
88_L 155_V 1.019 0.45
326_F 330_L 1.019 0.45
292_Y 310_S 1.016 0.45
81_W 208_L 1.013 0.44
188_L 233_A 1.013 0.44
118_S 332_G 1.012 0.44
121_G 325_L 1.009 0.44
104_R 298_G 1.009 0.44
172_H 279_G 1.008 0.44
272_I 341_T 1.008 0.44
71_G 93_L 1.007 0.44
32_G 115_W 1.007 0.44
58_Q 124_A 1.006 0.44
16_L 33_P 1.006 0.44
195_T 198_C 1.005 0.43
278_W 282_R 1.004 0.43
16_L 20_F 1.003 0.43
63_C 188_L 1.002 0.43
14_L 85_L 1 0.43
121_G 210_P 1 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zuxA10.856396.80.915Contact Map0.138
4bwzA10.959893.50.932Contact Map0.197
2kv5A10.071880.97Contact Map0.245
4b4aA10.26725.20.973Contact Map0.401
4httA20.2732.90.976Contact Map0.317
2l2tA20.12642.80.976Contact Map0
1zcdA20.4772.50.977Contact Map0.134
1ciiA10.17242.40.977Contact Map0
3j01A10.28742.40.977Contact Map0.067
3dinC20.29022.30.977Contact Map0.022

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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