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C56I - Cytochrome b561 homolog 2
UniProt: P75925 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12659
Length: 188 (179)
Sequences: 1256
Seq/Len: 7.02

C56I
Paralog alert: 0.76 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: C561 C56H C56I
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
165_K 170_D 4.26 1.00
109_Y 113_T 3.272 1.00
164_L 168_F 3.266 1.00
25_V 101_L 2.926 1.00
21_S 63_L 2.857 1.00
14_S 69_W 2.553 1.00
95_L 99_L 2.536 1.00
167_H 174_T 2.478 1.00
54_S 122_F 2.244 1.00
21_S 101_L 2.205 1.00
83_S 86_T 2.173 1.00
93_G 158_M 2.071 1.00
21_S 62_G 2.033 1.00
13_I 69_W 1.975 1.00
63_L 101_L 1.948 1.00
11_G 14_S 1.929 1.00
88_L 91_R 1.888 1.00
11_G 69_W 1.837 1.00
167_H 175_L 1.767 1.00
11_G 73_S 1.749 1.00
32_G 35_M 1.739 1.00
16_A 20_L 1.732 1.00
14_S 73_S 1.66 1.00
167_H 176_K 1.635 1.00
53_K 112_S 1.512 0.99
60_M 109_Y 1.506 0.99
156_S 160_G 1.503 0.99
63_L 102_F 1.479 0.99
61_M 68_L 1.466 0.99
58_L 121_V 1.417 0.99
167_H 173_D 1.413 0.99
90_A 93_G 1.402 0.99
113_T 130_T 1.395 0.99
143_A 146_F 1.393 0.99
134_A 137_Q 1.375 0.99
137_Q 140_F 1.364 0.98
174_T 177_R 1.361 0.98
158_M 162_M 1.35 0.98
67_V 102_F 1.339 0.98
169_I 172_D 1.33 0.98
106_I 110_L 1.327 0.98
152_V 156_S 1.316 0.98
79_L 174_T 1.31 0.98
98_Y 101_L 1.276 0.97
70_R 75_P 1.273 0.97
93_G 162_M 1.271 0.97
5_N 11_G 1.257 0.97
162_M 172_D 1.244 0.97
69_W 73_S 1.226 0.96
103_A 148_L 1.22 0.96
92_A 95_L 1.218 0.96
110_L 141_A 1.203 0.96
173_D 176_K 1.2 0.96
17_F 65_I 1.195 0.96
84_P 88_L 1.194 0.96
29_F 156_S 1.186 0.95
150_W 154_V 1.155 0.94
10_Y 14_S 1.152 0.94
64_V 68_L 1.148 0.94
28_M 59_L 1.139 0.94
25_V 63_L 1.123 0.93
57_I 119_I 1.118 0.93
157_V 161_F 1.106 0.93
163_A 167_H 1.096 0.92
60_M 105_G 1.081 0.92
27_G 55_I 1.078 0.91
13_I 16_A 1.077 0.91
51_L 55_I 1.074 0.91
82_Y 174_T 1.074 0.91
88_L 92_A 1.073 0.91
99_L 161_F 1.071 0.91
119_I 127_V 1.063 0.91
84_P 87_R 1.058 0.90
107_S 149_A 1.055 0.90
175_L 179_L 1.054 0.90
32_G 49_P 1.043 0.89
101_L 105_G 1.043 0.89
154_V 158_M 1.036 0.89
92_A 96_A 1.012 0.88
67_V 95_L 1.011 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gd3A20.99471000.466Contact Map0.343
1kqfC10.898999.90.511Contact Map0.516
1qleD10.19158.40.952Contact Map0.418
1m56D20.19157.50.953Contact Map0.539
3cx5C20.65962.90.961Contact Map0.383
1pp9C20.92552.70.962Contact Map0.34
1fftC20.56912.50.963Contact Map0.117
2yevA20.55322.30.963Contact Map0.225
4ev6A50.38831.80.965Contact Map0.395
1v54C20.56381.80.965Contact Map0.239

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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