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COMR - HTH-type transcriptional repressor ComR
UniProt: P75952 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13435
Length: 210 (193)
Sequences: 15864
Seq/Len: 82.20

COMR
Paralog alert: 0.83 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: ACRR BDCR BETI COMR ENVR NEMR RUTR SLMA UIDR YBIH YBJK YJDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
35_H 44_D 4.033 1.00
30_K 48_A 3.901 1.00
43_A 53_A 3.293 1.00
61_T 65_G 2.978 1.00
149_Q 168_T 2.495 1.00
34_Q 48_A 2.416 1.00
96_A 154_Q 2.388 1.00
92_S 95_S 2.299 1.00
31_L 40_T 2.289 1.00
22_D 73_R 2.246 1.00
32_F 40_T 2.239 1.00
20_D 23_A 2.188 1.00
52_K 55_T 2.15 1.00
62_N 65_G 2.051 1.00
21_R 69_A 1.966 1.00
153_C 157_A 1.96 1.00
153_C 167_V 1.959 1.00
46_V 56_L 1.924 1.00
27_K 48_A 1.907 1.00
69_A 72_D 1.869 1.00
23_A 27_K 1.821 1.00
22_D 26_D 1.818 1.00
149_Q 153_C 1.748 1.00
43_A 47_E 1.741 1.00
83_E 147_T 1.74 1.00
28_A 32_F 1.739 1.00
72_D 136_T 1.72 1.00
31_L 44_D 1.673 1.00
31_L 35_H 1.667 1.00
145_E 172_E 1.665 1.00
64_E 130_S 1.659 1.00
153_C 156_Q 1.659 1.00
26_D 73_R 1.633 1.00
92_S 160_E 1.627 1.00
31_L 48_A 1.604 1.00
29_M 73_R 1.603 1.00
155_R 161_I 1.599 1.00
40_T 45_L 1.571 1.00
65_G 69_A 1.507 1.00
32_F 37_Y 1.501 1.00
102_A 195_M 1.471 1.00
36_G 40_T 1.453 1.00
73_R 77_R 1.431 1.00
42_L 57_Y 1.417 1.00
27_K 30_K 1.409 1.00
28_A 66_L 1.406 0.99
68_R 136_T 1.395 0.99
25_L 69_A 1.388 0.99
37_Y 67_F 1.377 0.99
98_A 199_G 1.37 0.99
36_G 39_A 1.34 0.99
42_L 56_L 1.339 0.99
21_R 59_E 1.327 0.99
41_S 44_D 1.326 0.99
30_K 34_Q 1.323 0.99
155_R 160_E 1.322 0.99
93_V 158_R 1.297 0.99
173_F 177_I 1.293 0.99
27_K 49_T 1.283 0.99
169_H 196_Q 1.279 0.99
98_A 102_A 1.271 0.99
156_Q 167_V 1.259 0.99
51_A 55_T 1.252 0.99
152_L 167_V 1.247 0.99
95_S 99_D 1.242 0.98
44_D 47_E 1.232 0.98
94_E 98_A 1.221 0.98
60_F 69_A 1.217 0.98
45_L 66_L 1.217 0.98
154_Q 158_R 1.217 0.98
68_R 72_D 1.214 0.98
96_A 151_F 1.213 0.98
176_C 180_G 1.213 0.98
149_Q 167_V 1.209 0.98
44_D 48_A 1.199 0.98
42_L 53_A 1.197 0.98
25_L 70_V 1.185 0.98
72_D 76_D 1.164 0.97
29_M 70_V 1.151 0.97
26_D 30_K 1.151 0.97
190_S 193_K 1.148 0.97
145_E 168_T 1.14 0.97
64_E 132_D 1.13 0.97
35_H 40_T 1.125 0.97
55_T 58_A 1.119 0.96
57_Y 62_N 1.118 0.96
156_Q 163_P 1.117 0.96
20_D 59_E 1.112 0.96
142_A 146_R 1.101 0.96
151_F 155_R 1.095 0.96
166_D 169_H 1.075 0.95
27_K 31_L 1.059 0.95
35_H 39_A 1.034 0.94
56_L 66_L 1.031 0.94
52_K 58_A 1.028 0.94
25_L 60_F 1.026 0.94
37_Y 63_K 1.012 0.93
146_R 150_Q 1.01 0.93
19_F 22_D 1.002 0.92
162_P 165_C 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bruA211000.245Contact Map0.719
3eupA20.95711000.251Contact Map0.752
2i10A20.95241000.259Contact Map0.723
2xdnA40.96191000.26Contact Map0.724
2hyjA10.94761000.262Contact Map0.629
3knwA20.97141000.263Contact Map0.751
3qbmA20.93811000.268Contact Map0.656
2w53A20.96191000.278Contact Map0.792
3g1oA10.97141000.279Contact Map0.658
2g7sA10.92381000.282Contact Map0.643

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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