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LOLD - Lipoprotein-releasing system ATP-binding protein LolD
UniProt: P75957 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13440
Length: 233 (223)
Sequences: 70215
Seq/Len: 314.87

LOLD
Paralog alert: 0.95 [within 20: 0.86] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
7_Q 31_S 3.053 1.00
36_E 214_R 2.993 1.00
138_R 141_H 2.928 1.00
65_D 72_P 2.91 1.00
9_D 65_D 2.852 1.00
10_N 27_N 2.843 1.00
88_K 165_R 2.823 1.00
23_D 26_H 2.612 1.00
7_Q 67_I 2.578 1.00
38_M 216_L 2.563 1.00
131_K 136_D 2.544 1.00
26_H 222_R 2.422 1.00
33_G 36_E 2.413 1.00
12_C 27_N 2.242 1.00
8_C 11_L 2.227 1.00
39_A 212_M 2.219 1.00
125_R 163_N 2.169 1.00
13_K 54_L 2.166 1.00
14_R 23_D 2.137 1.00
69_N 165_R 2.125 1.00
214_R 226_E 2.094 1.00
12_C 23_D 2.03 1.00
127_L 139_A 2.016 1.00
12_C 63_S 2.008 1.00
130_L 139_A 1.931 1.00
104_A 146_L 1.917 1.00
39_A 213_S 1.883 1.00
105_L 140_N 1.869 1.00
9_D 67_I 1.863 1.00
216_L 223_L 1.825 1.00
190_E 194_L 1.816 1.00
105_L 139_A 1.794 1.00
34_E 165_R 1.774 1.00
10_N 29_S 1.735 1.00
105_L 127_L 1.725 1.00
163_N 197_T 1.696 1.00
132_A 190_E 1.671 1.00
15_Y 24_V 1.638 1.00
105_L 126_A 1.589 1.00
13_K 62_T 1.574 1.00
128_E 132_A 1.56 1.00
118_K 121_E 1.528 1.00
125_R 128_E 1.516 1.00
132_A 194_L 1.511 1.00
123_N 127_L 1.501 1.00
132_A 195_Q 1.46 1.00
141_H 145_E 1.452 1.00
52_L 202_V 1.446 1.00
13_K 59_D 1.431 1.00
14_R 62_T 1.424 1.00
105_L 109_A 1.411 1.00
105_L 123_N 1.396 0.99
67_I 72_P 1.386 0.99
94_Q 148_G 1.369 0.99
69_N 88_K 1.367 0.99
8_C 55_L 1.366 0.99
216_L 226_E 1.35 0.99
9_D 31_S 1.345 0.99
32_V 38_M 1.338 0.99
124_S 128_E 1.333 0.99
109_A 122_I 1.32 0.99
25_L 54_L 1.307 0.99
54_L 61_P 1.303 0.99
109_A 126_A 1.303 0.99
30_F 216_L 1.293 0.99
12_C 26_H 1.276 0.99
136_D 139_A 1.27 0.99
169_A 188_L 1.266 0.99
8_C 30_F 1.262 0.99
77_S 80_A 1.261 0.99
16_Q 21_Q 1.253 0.99
103_T 106_E 1.248 0.99
5_L 69_N 1.225 0.98
52_L 168_L 1.218 0.98
108_V 161_V 1.218 0.98
11_L 61_P 1.216 0.98
107_N 158_R 1.199 0.98
36_E 213_S 1.197 0.98
9_D 29_S 1.187 0.98
127_L 131_K 1.182 0.98
125_R 129_M 1.18 0.98
72_P 75_K 1.17 0.97
37_M 199_F 1.161 0.97
203_T 209_A 1.155 0.97
129_M 161_V 1.154 0.97
55_L 200_L 1.153 0.97
192_N 199_F 1.153 0.97
15_Y 50_T 1.146 0.97
37_M 192_N 1.142 0.97
104_A 154_V 1.139 0.97
189_G 192_N 1.121 0.97
33_G 214_R 1.115 0.96
187_L 190_E 1.095 0.96
138_R 150_E 1.093 0.96
127_L 136_D 1.088 0.96
109_A 123_N 1.088 0.96
53_H 59_D 1.088 0.96
51_L 218_M 1.078 0.95
8_C 51_L 1.071 0.95
133_V 157_A 1.069 0.95
13_K 50_T 1.068 0.95
181_A 208_L 1.06 0.95
34_E 69_N 1.053 0.95
38_M 214_R 1.045 0.94
92_I 156_I 1.045 0.94
169_A 199_F 1.044 0.94
54_L 66_V 1.026 0.94
163_N 195_Q 1.026 0.94
185_F 208_L 1.026 0.94
108_V 130_L 1.025 0.93
28_V 51_L 1.024 0.93
92_I 169_A 1.02 0.93
165_R 197_T 1.02 0.93
146_L 154_V 1.019 0.93
142_R 145_E 1.019 0.93
56_G 91_F 1.018 0.93
112_L 161_V 1.005 0.93
219_R 224_T 1.004 0.93
128_E 131_K 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9957100-0.015Contact Map0.874
1g29120.97421000.006Contact Map0.892
1v43A10.95711000.008Contact Map0.807
1oxxK10.97851000.009Contact Map0.819
2yyzA10.94851000.01Contact Map0.808
2it1A20.94851000.011Contact Map0.86
3rlfA20.94851000.015Contact Map0.832
3fvqA20.971000.017Contact Map0.769
1z47A20.95711000.017Contact Map0.825
4mkiB20.98711000.03Contact Map0.799

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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