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COHE - Putative lambdoid prophage e14 repressor protein C2
UniProt: P75974 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14249
Length: 224 (213)
Sequences: 1694
Seq/Len: 7.95

COHE
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: COHE LEXA UMUD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
177_R 190_L 3.341 1.00
144_R 147_D 3.079 1.00
13_R 40_M 2.992 1.00
100_A 134_V 2.551 1.00
142_E 190_L 2.47 1.00
137_D 194_W 2.304 1.00
149_I 175_F 2.251 1.00
98_V 164_I 2.109 1.00
29_I 59_C 2.041 1.00
22_N 33_P 2.024 1.00
143_Y 162_D 1.935 1.00
131_I 150_F 1.93 1.00
36_T 39_F 1.893 1.00
22_N 40_M 1.893 1.00
4_I 9_R 1.88 1.00
23_S 27_T 1.876 1.00
26_A 29_I 1.874 1.00
188_K 196_E 1.866 1.00
134_V 143_Y 1.865 1.00
25_F 36_T 1.838 1.00
174_T 189_A 1.833 1.00
35_Q 38_R 1.799 1.00
101_G 136_G 1.765 1.00
138_S 176_K 1.76 1.00
31_R 36_T 1.745 1.00
166_L 206_S 1.741 1.00
57_E 62_L 1.73 1.00
39_F 47_N 1.715 1.00
101_G 176_K 1.69 1.00
32_E 35_Q 1.689 1.00
66_W 70_E 1.645 1.00
24_S 28_M 1.636 1.00
23_S 33_P 1.612 1.00
33_P 37_S 1.561 1.00
28_M 59_C 1.554 1.00
151_V 211_V 1.538 1.00
174_T 197_P 1.525 1.00
34_T 37_S 1.512 1.00
38_R 44_A 1.507 1.00
31_R 35_Q 1.503 1.00
134_V 149_I 1.481 0.99
66_W 72_Q 1.475 0.99
176_K 189_A 1.445 0.99
137_D 193_N 1.435 0.99
34_T 38_R 1.415 0.99
99_Q 103_W 1.369 0.99
92_V 131_I 1.369 0.99
131_I 148_M 1.366 0.99
8_R 66_W 1.366 0.99
63_P 66_W 1.361 0.99
51_S 55_H 1.353 0.99
151_V 164_I 1.312 0.98
33_P 39_F 1.301 0.98
128_M 154_E 1.292 0.98
130_Y 153_P 1.289 0.98
175_F 211_V 1.288 0.98
178_L 187_L 1.278 0.98
24_S 27_T 1.276 0.98
36_T 40_M 1.249 0.98
165_A 187_L 1.238 0.97
165_A 178_L 1.237 0.97
8_R 11_N 1.233 0.97
177_R 188_K 1.233 0.97
136_G 145_P 1.229 0.97
32_E 38_R 1.223 0.97
98_V 101_G 1.211 0.97
38_R 45_T 1.194 0.97
31_R 39_F 1.181 0.96
161_D 210_T 1.179 0.96
62_L 66_W 1.179 0.96
65_G 68_D 1.178 0.96
22_N 37_S 1.169 0.96
10_S 13_R 1.166 0.96
21_G 24_S 1.15 0.95
39_F 56_I 1.14 0.95
179_I 188_K 1.126 0.95
147_D 216_K 1.126 0.95
10_S 40_M 1.118 0.95
12_A 16_R 1.118 0.95
129_T 152_D 1.114 0.94
38_R 42_D 1.113 0.94
180_E 185_R 1.112 0.94
132_L 173_T 1.112 0.94
143_Y 214_S 1.107 0.94
25_F 56_I 1.105 0.94
5_H 13_R 1.101 0.94
35_Q 39_F 1.093 0.94
66_W 69_Q 1.089 0.93
152_D 155_V 1.078 0.93
157_A 163_V 1.069 0.93
11_N 15_L 1.066 0.92
45_T 48_I 1.055 0.92
62_L 68_D 1.047 0.92
138_S 191_N 1.047 0.92
63_P 68_D 1.041 0.91
140_I 144_R 1.034 0.91
162_D 177_R 1.016 0.90
39_F 49_G 1.015 0.90
22_N 26_A 1.007 0.89
31_R 51_S 1.007 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bdnA20.95091000.228Contact Map0.638
2fjrA20.82141000.361Contact Map0.555
1jhfA20.84821000.379Contact Map0.636
3k2zA20.82141000.436Contact Map0.634
2hnfA10.562599.90.502Contact Map0.739
1umuA20.495599.80.55Contact Map0.857
1kcaA80.459899.80.58Contact Map0.903
2bnmA20.81799.80.588Contact Map0.453
1dw9A100.607199.60.661Contact Map0.536
2r1jL20.294699.30.707Contact Map0.784

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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