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YCGF - Blue light- and temperature-regulated antirepressor YcgF
UniProt: P75990 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13887
Length: 403 (386)
Sequences: 831
Seq/Len: 2.15

YCGF
Paralog alert: 0.35 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: ADRB CSRD DOSP GMR RTN YAHA YCGF YCGG YDIV YHJH YHJK YJCC YLAB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
364_V 381_F 3.613 1.00
218_D 247_T 3.59 1.00
182_P 381_F 3.186 1.00
387_A 390_K 3.14 1.00
329_Q 333_T 2.961 1.00
243_L 254_A 2.928 1.00
223_A 264_A 2.86 1.00
174_F 220_K 2.776 1.00
296_K 323_D 2.468 1.00
172_D 194_V 2.45 1.00
206_V 214_I 2.364 1.00
318_S 341_R 2.267 1.00
259_L 298_A 2.19 1.00
209_R 217_A 2.174 1.00
261_E 265_N 2.166 1.00
176_F 228_M 2.112 0.99
262_I 300_I 2.095 0.99
206_V 277_T 2.086 0.99
353_T 379_E 2.067 0.99
194_V 217_A 2.059 0.99
306_H 362_M 1.978 0.99
384_D 389_A 1.944 0.99
181_D 184_S 1.914 0.99
358_Q 379_E 1.881 0.99
132_F 135_A 1.853 0.98
162_D 198_E 1.843 0.98
43_N 46_H 1.827 0.98
209_R 213_E 1.775 0.98
292_I 302_V 1.775 0.98
43_N 47_F 1.764 0.97
129_F 132_F 1.744 0.97
175_A 391_L 1.726 0.97
361_A 373_L 1.661 0.96
113_G 116_K 1.65 0.96
195_Q 202_S 1.642 0.96
44_G 48_F 1.621 0.95
275_E 326_K 1.607 0.95
41_L 44_G 1.606 0.95
206_V 210_K 1.558 0.94
222_K 258_L 1.545 0.93
43_N 48_F 1.544 0.93
262_I 269_P 1.524 0.93
44_G 47_F 1.494 0.92
277_T 362_M 1.488 0.92
373_L 378_I 1.475 0.91
174_F 221_S 1.467 0.91
372_W 376_A 1.461 0.91
310_G 362_M 1.45 0.90
262_I 272_I 1.446 0.90
136_T 139_S 1.444 0.90
367_P 371_M 1.435 0.90
132_F 136_T 1.418 0.89
366_T 369_E 1.418 0.89
179_I 189_A 1.415 0.89
193_I 362_M 1.415 0.89
45_S 48_F 1.403 0.88
273_I 324_R 1.403 0.88
202_S 205_A 1.378 0.87
180_V 386_F 1.376 0.87
59_K 67_Q 1.372 0.87
277_T 306_H 1.369 0.87
39_I 43_N 1.367 0.86
9_S 16_P 1.364 0.86
9_S 12_R 1.356 0.86
174_F 194_V 1.342 0.85
195_Q 305_D 1.339 0.85
217_A 221_S 1.335 0.85
172_D 220_K 1.329 0.84
275_E 362_M 1.327 0.84
194_V 221_S 1.321 0.84
329_Q 363_G 1.32 0.84
59_K 68_D 1.319 0.84
173_H 197_N 1.314 0.83
170_I 224_L 1.308 0.83
200_S 206_V 1.306 0.83
309_A 331_L 1.305 0.83
68_D 71_H 1.304 0.83
179_I 273_I 1.296 0.82
171_N 196_K 1.293 0.82
12_R 16_P 1.29 0.82
9_S 14_D 1.284 0.81
258_L 300_I 1.279 0.81
182_P 364_V 1.274 0.81
137_E 140_T 1.273 0.81
139_S 143_E 1.271 0.80
101_E 104_D 1.27 0.80
325_I 364_V 1.262 0.80
210_K 214_I 1.262 0.80
219_L 257_F 1.258 0.79
209_R 214_I 1.257 0.79
228_M 392_N 1.252 0.79
223_A 265_N 1.248 0.79
174_F 192_A 1.238 0.78
282_I 320_F 1.237 0.78
277_T 365_A 1.234 0.78
86_R 92_M 1.234 0.78
228_M 232_L 1.231 0.77
325_I 352_C 1.224 0.77
241_I 272_I 1.224 0.77
34_S 37_T 1.221 0.77
328_S 331_L 1.22 0.77
220_K 224_L 1.219 0.76
191_E 242_N 1.219 0.76
193_I 242_N 1.217 0.76
64_A 67_Q 1.215 0.76
328_S 362_M 1.213 0.76
193_I 275_E 1.211 0.76
193_I 277_T 1.207 0.75
245_P 279_S 1.206 0.75
242_N 277_T 1.205 0.75
326_K 362_M 1.204 0.75
96_D 99_L 1.197 0.75
67_Q 71_H 1.194 0.74
144_I 147_E 1.19 0.74
135_A 142_F 1.19 0.74
242_N 326_K 1.187 0.74
193_I 306_H 1.184 0.73
361_A 378_I 1.184 0.73
193_I 365_A 1.18 0.73
345_I 361_A 1.177 0.73
137_E 142_F 1.173 0.72
195_Q 362_M 1.171 0.72
163_S 209_R 1.169 0.72
381_F 386_F 1.166 0.72
311_F 362_M 1.165 0.72
196_K 247_T 1.158 0.71
362_M 384_D 1.157 0.71
242_N 365_A 1.154 0.71
191_E 326_K 1.15 0.70
279_S 304_I 1.14 0.69
222_K 241_I 1.135 0.69
179_I 380_M 1.133 0.69
329_Q 369_E 1.126 0.68
63_R 67_Q 1.124 0.68
143_E 147_E 1.123 0.68
202_S 305_D 1.116 0.67
60_M 63_R 1.112 0.67
364_V 373_L 1.111 0.66
43_N 90_A 1.111 0.66
59_K 63_R 1.105 0.66
41_L 48_F 1.103 0.66
233_E 271_Q 1.099 0.65
137_E 141_Y 1.099 0.65
229_A 267_L 1.098 0.65
192_A 239_I 1.095 0.65
314_L 363_G 1.091 0.64
196_K 363_G 1.091 0.64
132_F 137_E 1.082 0.63
277_T 312_A 1.08 0.63
193_I 384_D 1.079 0.63
91_G 95_F 1.078 0.63
139_S 144_I 1.071 0.62
181_D 188_I 1.067 0.62
60_M 64_A 1.06 0.61
174_F 222_K 1.059 0.61
307_F 310_G 1.059 0.61
363_G 369_E 1.058 0.61
262_I 268_V 1.053 0.60
303_A 327_I 1.052 0.60
59_K 64_A 1.051 0.60
202_S 362_M 1.049 0.60
226_F 272_I 1.047 0.60
310_G 326_K 1.045 0.59
195_Q 365_A 1.044 0.59
242_N 331_L 1.042 0.59
370_W 386_F 1.041 0.59
242_N 305_D 1.039 0.59
268_V 271_Q 1.038 0.59
196_K 199_D 1.037 0.59
306_H 310_G 1.035 0.58
140_T 143_E 1.034 0.58
58_V 70_R 1.032 0.58
335_V 376_A 1.031 0.58
327_I 348_I 1.029 0.58
345_I 352_C 1.027 0.57
305_D 362_M 1.026 0.57
163_S 172_D 1.024 0.57
64_A 68_D 1.023 0.57
135_A 139_S 1.021 0.57
9_S 13_D 1.021 0.57
254_A 258_L 1.018 0.56
370_W 385_L 1.016 0.56
224_L 227_T 1.012 0.56
171_N 199_D 1.01 0.56
309_A 362_M 1.008 0.55
70_R 75_V 1.008 0.55
176_F 192_A 1.006 0.55
20_I 24_V 1.005 0.55
13_D 16_P 1.003 0.55
226_F 258_L 1.003 0.55
224_L 228_M 1.002 0.55
344_I 361_A 1.001 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gfzA20.98761000.215Contact Map0.462
3hvbA20.96771000.251Contact Map0.549
3pjxA10.9381000.257Contact Map0.453
4hjfA10.78411000.348Contact Map0.513
4hu4A20.69231000.361Contact Map0.57
2r6oA20.66751000.399Contact Map0.659
3sy8A40.91561000.412Contact Map0.628
3s83A10.60791000.423Contact Map0.545
4fojA10.64021000.431Contact Map0.579
3hv8A10.64761000.434Contact Map0.546

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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