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CVRA - Cell volume regulation protein A
UniProt: P76007 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13896
Length: 578 (566)
Sequences: 630
Seq/Len: 1.11

CVRA
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
194_Q 242_E 2.893 1.00
110_M 308_W 2.632 1.00
166_V 349_L 2.194 0.98
47_V 291_N 2.172 0.98
294_D 366_N 2.138 0.98
432_L 443_I 1.989 0.96
421_L 461_L 1.937 0.95
48_D 293_S 1.876 0.94
112_A 122_G 1.865 0.94
95_L 318_V 1.852 0.94
300_I 304_I 1.793 0.92
159_G 250_Y 1.729 0.90
201_I 238_T 1.722 0.90
234_I 252_C 1.684 0.89
235_F 378_L 1.636 0.87
22_L 312_F 1.569 0.83
501_L 529_L 1.547 0.82
16_L 45_A 1.543 0.82
40_A 303_L 1.532 0.81
191_I 195_F 1.519 0.81
134_A 372_V 1.509 0.80
386_A 389_K 1.509 0.80
111_A 305_L 1.489 0.79
123_L 192_L 1.488 0.79
209_L 230_G 1.476 0.78
24_S 38_F 1.475 0.78
116_N 307_A 1.472 0.78
104_S 127_A 1.465 0.77
111_A 122_G 1.457 0.77
43_M 290_V 1.455 0.76
299_A 370_F 1.447 0.76
110_M 114_L 1.426 0.74
423_A 463_E 1.426 0.74
119_L 122_G 1.426 0.74
48_D 361_A 1.423 0.74
103_T 317_S 1.416 0.74
498_D 513_I 1.407 0.73
238_T 248_A 1.404 0.73
385_W 389_K 1.398 0.72
282_M 348_I 1.397 0.72
203_L 255_L 1.397 0.72
48_D 296_L 1.389 0.72
216_I 229_S 1.383 0.71
115_F 232_I 1.372 0.70
166_V 244_S 1.368 0.70
105_G 361_A 1.368 0.70
203_L 207_Y 1.358 0.69
289_L 292_P 1.341 0.68
118_D 121_E 1.337 0.67
136_A 246_I 1.328 0.67
53_I 122_G 1.327 0.67
104_S 169_T 1.326 0.67
222_L 276_W 1.323 0.66
276_W 279_Q 1.323 0.66
510_V 529_L 1.318 0.66
506_K 509_D 1.313 0.65
208_L 316_L 1.309 0.65
218_L 223_Y 1.304 0.65
504_S 535_Q 1.281 0.63
270_N 400_P 1.28 0.62
244_S 349_L 1.278 0.62
122_G 236_S 1.275 0.62
21_I 232_I 1.266 0.61
191_I 320_A 1.254 0.60
198_G 202_G 1.245 0.59
310_I 339_V 1.243 0.59
40_A 44_L 1.238 0.59
313_A 349_L 1.233 0.58
214_N 262_R 1.23 0.58
17_V 123_L 1.23 0.58
43_M 49_G 1.228 0.58
524_D 536_L 1.227 0.58
329_N 333_R 1.22 0.57
113_W 123_L 1.211 0.56
535_Q 560_E 1.202 0.55
127_A 172_L 1.202 0.55
546_Q 553_I 1.198 0.55
14_S 21_I 1.195 0.55
193_Q 197_L 1.191 0.54
78_M 275_A 1.19 0.54
527_Q 535_Q 1.181 0.53
75_D 79_R 1.179 0.53
71_I 78_M 1.175 0.53
9_L 213_I 1.174 0.53
526_Q 531_E 1.169 0.52
177_Q 469_V 1.168 0.52
507_Y 532_I 1.167 0.52
500_I 527_Q 1.163 0.52
136_A 372_V 1.163 0.52
35_L 138_F 1.162 0.51
96_A 256_L 1.161 0.51
335_F 392_V 1.159 0.51
525_K 534_Q 1.156 0.51
490_A 500_I 1.154 0.51
332_E 335_F 1.154 0.51
204_G 440_E 1.152 0.51
513_I 561_D 1.151 0.50
382_S 385_W 1.15 0.50
527_Q 571_V 1.149 0.50
332_E 372_V 1.141 0.49
112_A 119_L 1.134 0.49
506_K 548_E 1.128 0.48
506_K 540_A 1.128 0.48
319_F 330_L 1.125 0.48
512_L 525_K 1.125 0.48
136_A 345_V 1.125 0.48
102_I 106_L 1.123 0.48
108_G 395_P 1.121 0.48
534_Q 565_L 1.117 0.47
133_D 158_S 1.117 0.47
122_G 305_L 1.117 0.47
368_A 419_Y 1.114 0.47
64_V 410_P 1.113 0.47
134_A 158_S 1.112 0.47
525_K 551_G 1.111 0.47
223_Y 276_W 1.108 0.46
122_G 130_G 1.106 0.46
250_Y 344_A 1.106 0.46
540_A 559_K 1.106 0.46
517_E 550_A 1.105 0.46
532_I 561_D 1.102 0.46
171_T 187_F 1.099 0.45
246_I 275_A 1.099 0.45
133_D 380_G 1.098 0.45
134_A 348_I 1.098 0.45
37_I 66_N 1.097 0.45
17_V 275_A 1.097 0.45
80_T 131_S 1.094 0.45
61_A 64_V 1.094 0.45
136_A 353_P 1.093 0.45
76_G 245_G 1.091 0.45
499_F 514_Y 1.09 0.45
489_V 494_R 1.09 0.45
199_I 471_G 1.09 0.45
132_T 161_N 1.089 0.45
506_K 512_L 1.089 0.45
65_S 248_A 1.089 0.45
508_A 518_D 1.089 0.45
203_L 251_L 1.089 0.45
10_F 317_S 1.088 0.44
197_L 243_G 1.087 0.44
45_A 136_A 1.087 0.44
279_Q 288_L 1.087 0.44
127_A 130_G 1.085 0.44
155_E 161_N 1.084 0.44
489_V 566_K 1.082 0.44
158_S 341_L 1.08 0.44
453_L 462_R 1.08 0.44
161_N 340_G 1.08 0.44
132_T 342_R 1.078 0.44
56_D 291_N 1.078 0.44
114_L 192_L 1.077 0.43
305_L 377_L 1.077 0.43
200_V 203_L 1.077 0.43
490_A 553_I 1.075 0.43
308_W 374_V 1.074 0.43
100_V 131_S 1.072 0.43
352_F 370_F 1.072 0.43
122_G 424_D 1.071 0.43
41_I 95_L 1.071 0.43
494_R 527_Q 1.069 0.43
208_L 211_Q 1.068 0.43
138_F 338_W 1.068 0.43
527_Q 534_Q 1.068 0.43
211_Q 320_A 1.067 0.42
546_Q 550_A 1.064 0.42
80_T 134_A 1.063 0.42
158_S 347_I 1.063 0.42
491_L 539_A 1.063 0.42
316_L 421_L 1.063 0.42
240_A 383_L 1.062 0.42
295_L 450_N 1.06 0.42
511_A 516_L 1.06 0.42
150_V 332_E 1.059 0.42
211_Q 215_R 1.059 0.42
1_M 5_T 1.058 0.42
31_G 280_I 1.057 0.42
69_L 345_V 1.056 0.41
533_V 559_K 1.056 0.41
113_W 192_L 1.056 0.41
65_S 276_W 1.055 0.41
163_P 169_T 1.054 0.41
505_A 517_E 1.054 0.41
72_I 314_R 1.053 0.41
102_I 105_G 1.051 0.41
494_R 566_K 1.05 0.41
133_D 136_A 1.05 0.41
290_V 366_N 1.049 0.41
157_E 315_P 1.048 0.41
524_D 527_Q 1.048 0.41
1_M 183_I 1.047 0.41
14_S 171_T 1.046 0.41
62_Y 351_V 1.045 0.40
551_G 566_K 1.045 0.40
132_T 380_G 1.044 0.40
29_R 172_L 1.044 0.40
55_F 61_A 1.044 0.40
133_D 157_E 1.043 0.40
192_L 208_L 1.043 0.40
159_G 379_Q 1.041 0.40
202_G 314_R 1.041 0.40
96_A 382_S 1.04 0.40
167_F 246_I 1.04 0.40
529_L 551_G 1.04 0.40
502_E 513_I 1.039 0.40
488_P 517_E 1.037 0.40
107_T 311_F 1.036 0.40
516_L 551_G 1.036 0.40
338_W 341_L 1.034 0.39
81_Q 127_A 1.033 0.39
541_P 569_V 1.033 0.39
66_N 74_L 1.033 0.39
500_I 536_L 1.032 0.39
501_L 505_A 1.031 0.39
32_I 381_T 1.03 0.39
453_L 467_L 1.03 0.39
291_N 294_D 1.029 0.39
530_G 534_Q 1.028 0.39
506_K 541_P 1.027 0.39
98_L 326_R 1.027 0.39
27_S 421_L 1.026 0.39
73_L 284_L 1.026 0.39
324_P 461_L 1.025 0.39
533_V 567_I 1.025 0.39
163_P 194_Q 1.025 0.39
132_T 344_A 1.025 0.39
494_R 540_A 1.023 0.38
272_D 376_L 1.023 0.38
160_S 169_T 1.022 0.38
163_P 375_S 1.021 0.38
137_V 201_I 1.021 0.38
80_T 159_G 1.02 0.38
558_E 566_K 1.02 0.38
132_T 157_E 1.019 0.38
131_S 158_S 1.018 0.38
31_G 221_G 1.018 0.38
506_K 517_E 1.016 0.38
502_E 565_L 1.015 0.38
533_V 547_V 1.014 0.38
503_A 566_K 1.013 0.38
157_E 342_R 1.013 0.38
157_E 286_L 1.013 0.38
133_D 161_N 1.012 0.37
73_L 353_P 1.011 0.37
159_G 344_A 1.011 0.37
440_E 475_D 1.01 0.37
209_L 234_I 1.01 0.37
208_L 294_D 1.009 0.37
275_A 346_P 1.009 0.37
487_P 563_E 1.009 0.37
39_L 345_V 1.008 0.37
159_G 341_L 1.008 0.37
234_I 256_L 1.008 0.37
293_S 296_L 1.007 0.37
502_E 507_Y 1.007 0.37
267_I 346_P 1.007 0.37
223_Y 346_P 1.007 0.37
368_A 390_A 1.006 0.37
109_M 424_D 1.006 0.37
169_T 375_S 1.006 0.37
307_A 316_L 1.005 0.37
491_L 562_N 1.005 0.37
160_S 244_S 1.004 0.37
494_R 564_V 1.004 0.37
168_L 375_S 1.004 0.37
223_Y 273_G 1.004 0.37
532_I 540_A 1.003 0.37
128_I 136_A 1.003 0.37
311_F 378_L 1.003 0.37
508_A 534_Q 1.002 0.37
506_K 526_Q 1.002 0.37
64_V 419_Y 1.001 0.36
552_M 567_I 1 0.36
560_E 565_L 1 0.36
524_D 532_I 1 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4bwzA10.6731000.683Contact Map0.187
1zcdA20.607399.70.892Contact Map0.157
3jxoA20.148899.20.921Contact Map0.77
1lnqA80.375498.90.929Contact Map0.687
3l4bC40.240598.90.931Contact Map0.285
2p13A20.150598.90.932Contact Map0.29
2nqwA10.155798.80.932Contact Map0.257
1vctA10.235398.80.932Contact Map0.576
2plsA120.147198.80.932Contact Map0.329
3llbA10.143698.80.933Contact Map0.24

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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