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OPPD - Oligopeptide transport ATP-binding protein OppD
UniProt: P76027 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10677
Length: 337 (317)
Sequences: 10080
Seq/Len: 31.80

OPPD
Paralog alert: 0.92 [within 20: 0.75] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
50_E 238_K 4.538 1.00
105_Q 188_K 3.81 1.00
23_K 82_S 3.433 1.00
21_N 45_S 3.384 1.00
24_D 41_D 3.254 1.00
149_M 184_L 3.109 1.00
251_G 256_V 3.049 1.00
53_G 236_C 2.842 1.00
152_A 218_F 2.776 1.00
27_V 68_A 2.774 1.00
86_N 188_K 2.64 1.00
240_L 247_T 2.593 1.00
52_L 240_L 2.568 1.00
252_N 255_D 2.556 1.00
82_S 89_E 2.541 1.00
48_A 188_K 2.514 1.00
238_K 250_Y 2.502 1.00
89_E 92_N 2.484 1.00
213_E 217_E 2.447 1.00
152_A 217_E 2.433 1.00
145_E 148_R 2.394 1.00
311_I 314_S 2.384 1.00
309_M 331_K 2.336 1.00
40_N 246_R 2.212 1.00
71_G 98_L 2.145 1.00
88_R 97_E 2.125 1.00
22_V 25_L 2.083 1.00
138_S 141_E 2.082 1.00
94_P 97_E 2.082 1.00
47_R 50_E 2.068 1.00
128_M 146_S 2.051 1.00
21_N 84_T 2.031 1.00
26_R 41_D 2.015 1.00
28_T 37_T 2.01 1.00
145_E 186_R 1.993 1.00
211_L 222_I 1.946 1.00
226_T 232_V 1.94 1.00
128_M 142_A 1.935 1.00
86_N 105_Q 1.929 1.00
22_V 44_F 1.916 1.00
161_R 164_M 1.882 1.00
24_D 43_N 1.867 1.00
29_F 64_Q 1.851 1.00
37_T 40_N 1.851 1.00
151_D 159_R 1.823 1.00
114_M 174_R 1.82 1.00
66_A 225_I 1.786 1.00
127_L 150_L 1.779 1.00
53_G 232_V 1.768 1.00
46_L 223_I 1.759 1.00
320_E 323_P 1.755 1.00
54_I 223_I 1.722 1.00
302_Q 313_S 1.719 1.00
147_V 162_M 1.697 1.00
18_A 47_R 1.676 1.00
109_I 192_A 1.66 1.00
255_D 259_Q 1.643 1.00
186_R 218_F 1.639 1.00
132_M 142_A 1.635 1.00
51_T 215_K 1.629 1.00
46_L 189_L 1.625 1.00
161_R 169_F 1.625 1.00
169_F 177_V 1.62 1.00
212_N 215_K 1.616 1.00
23_K 45_S 1.603 1.00
208_M 231_V 1.578 1.00
26_R 80_G 1.568 1.00
124_G 162_M 1.554 1.00
148_R 152_A 1.544 1.00
308_A 313_S 1.538 1.00
142_A 146_S 1.537 1.00
40_N 300_P 1.529 1.00
246_R 315_A 1.519 1.00
44_F 65_T 1.504 1.00
127_L 184_L 1.491 1.00
305_C 312_C 1.483 1.00
164_M 168_E 1.471 1.00
311_I 330_F 1.445 1.00
88_R 93_L 1.439 1.00
93_L 97_E 1.438 1.00
240_L 250_Y 1.432 1.00
157_E 160_K 1.426 1.00
98_L 102_R 1.422 1.00
246_R 328_A 1.417 1.00
143_F 163_K 1.412 1.00
299_C 305_C 1.397 0.99
23_K 84_T 1.389 0.99
192_A 222_I 1.385 0.99
121_M 125_E 1.375 0.99
122_R 163_K 1.367 0.99
23_K 43_N 1.349 0.99
31_T 34_G 1.347 0.99
19_L 189_L 1.336 0.99
155_M 161_R 1.335 0.99
318_L 328_A 1.331 0.99
48_A 219_N 1.326 0.99
143_F 162_M 1.314 0.99
246_R 300_P 1.312 0.99
46_L 52_L 1.3 0.99
147_V 159_R 1.299 0.99
42_L 65_T 1.299 0.99
310_E 313_S 1.296 0.99
65_T 242_M 1.296 0.99
152_A 213_E 1.282 0.99
297_K 302_Q 1.274 0.99
101_L 106_I 1.27 0.99
224_M 235_I 1.268 0.99
24_D 80_G 1.253 0.99
250_Y 326_L 1.248 0.99
124_G 163_K 1.245 0.98
84_T 89_E 1.244 0.98
154_K 213_E 1.242 0.98
127_L 146_S 1.241 0.98
143_F 147_V 1.24 0.98
299_C 312_C 1.226 0.98
52_L 250_Y 1.224 0.98
22_V 69_L 1.222 0.98
190_L 222_I 1.22 0.98
26_R 40_N 1.215 0.98
29_F 38_A 1.198 0.98
266_I 307_H 1.192 0.98
42_L 247_T 1.192 0.98
150_L 162_M 1.18 0.98
85_F 105_Q 1.179 0.98
144_E 148_R 1.177 0.98
19_L 85_F 1.168 0.97
135_K 145_E 1.16 0.97
160_K 164_M 1.158 0.97
28_T 35_D 1.156 0.97
299_C 329_C 1.148 0.97
73_L 77_G 1.146 0.97
44_F 240_L 1.141 0.97
117_L 174_R 1.141 0.97
54_I 240_L 1.139 0.97
122_R 125_E 1.139 0.97
117_L 177_V 1.135 0.97
312_C 329_C 1.134 0.97
93_L 98_L 1.133 0.97
18_A 21_N 1.131 0.97
26_R 37_T 1.129 0.97
28_T 40_N 1.126 0.97
239_V 253_A 1.118 0.96
51_T 222_I 1.107 0.96
124_G 143_F 1.106 0.96
254_R 258_Y 1.105 0.96
97_E 100_K 1.1 0.96
131_L 184_L 1.098 0.96
146_S 162_M 1.097 0.96
154_K 206_Q 1.088 0.96
85_F 189_L 1.084 0.96
327_R 332_P 1.077 0.95
73_L 76_N 1.075 0.95
266_I 270_N 1.073 0.95
90_I 106_I 1.072 0.95
215_K 237_D 1.067 0.95
314_S 330_F 1.066 0.95
48_A 86_N 1.065 0.95
69_L 83_A 1.065 0.95
320_E 324_G 1.058 0.95
66_A 191_I 1.056 0.95
20_L 69_L 1.051 0.94
55_V 232_V 1.05 0.94
148_R 151_D 1.043 0.94
141_E 144_E 1.043 0.94
300_P 315_A 1.038 0.94
155_M 173_M 1.025 0.93
70_M 106_I 1.023 0.93
320_E 326_L 1.018 0.93
140_A 144_E 1.01 0.93
255_D 322_T 1.006 0.93
256_V 265_S 1.005 0.93
106_I 189_L 1.004 0.93
71_G 74_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fwiB10.95251000.154Contact Map0.748
3tuiC40.95551000.385Contact Map0.859
1oxxK10.91391000.398Contact Map0.764
2it1A20.89321000.399Contact Map0.792
1g29120.91391000.402Contact Map0.827
2yyzA10.89321000.403Contact Map0.739
1v43A10.91391000.413Contact Map0.768
3rlfA20.89611000.413Contact Map0.783
3fvqA20.9081000.424Contact Map0.692
1z47A20.9051000.428Contact Map0.789

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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