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ABGB - p-aminobenzoyl-glutamate hydrolase subunit B
UniProt: P76052 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13351
Length: 481 (388)
Sequences: 4436
Seq/Len: 11.43

ABGB
Paralog alert: 0.55 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ABGA ABGB ALLC ARGE DAPE PEPT YGEY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
198_A 207_G 3.864 1.00
25_Q 38_W 3.515 1.00
275_A 279_E 3.409 1.00
192_R 290_E 3.162 1.00
213_A 287_T 3.116 1.00
194_K 288_T 3.042 1.00
242_G 253_A 2.945 1.00
48_E 56_R 2.928 1.00
68_S 139_R 2.893 1.00
272_D 276_K 2.799 1.00
192_R 252_Q 2.692 1.00
214_V 239_T 2.678 1.00
316_H 443_N 2.652 1.00
153_T 157_R 2.598 1.00
43_L 82_Y 2.494 1.00
46_A 49_S 2.442 1.00
393_S 398_V 2.431 1.00
25_Q 42_H 2.431 1.00
192_R 254_E 2.414 1.00
190_S 292_R 2.398 1.00
75_V 137_T 2.345 1.00
117_A 433_A 2.28 1.00
41_E 45_S 2.241 1.00
193_F 217_M 2.224 1.00
69_F 140_F 2.206 1.00
208_R 287_T 2.196 1.00
24_D 427_H 2.188 1.00
194_K 290_E 2.166 1.00
215_T 218_T 2.166 1.00
19_Y 434_A 2.123 1.00
43_L 115_G 2.118 1.00
41_E 56_R 2.118 1.00
271_Y 275_A 2.11 1.00
217_M 278_A 2.07 1.00
192_R 292_R 2.057 1.00
28_D 100_V 2.057 1.00
187_I 267_V 2.029 1.00
273_R 276_K 2.026 1.00
212_D 223_F 2.017 1.00
313_A 443_N 2.006 1.00
38_W 41_E 2.004 1.00
77_A 164_V 1.994 1.00
13_E 435_K 1.993 1.00
17_Q 21_D 1.993 1.00
312_Q 443_N 1.982 1.00
190_S 254_E 1.976 1.00
19_Y 120_A 1.919 1.00
214_V 255_V 1.906 1.00
77_A 167_A 1.9 1.00
194_K 252_Q 1.888 1.00
19_Y 116_T 1.884 1.00
44_A 56_R 1.854 1.00
279_E 283_L 1.83 1.00
26_I 42_H 1.828 1.00
93_G 97_P 1.821 1.00
282_A 289_V 1.799 1.00
113_L 425_I 1.788 1.00
214_V 253_A 1.759 1.00
311_Y 315_S 1.752 1.00
16_R 431_L 1.744 1.00
44_A 48_E 1.737 1.00
44_A 54_V 1.736 1.00
25_Q 29_H 1.729 1.00
37_F 63_N 1.724 1.00
210_A 250_Q 1.668 1.00
190_S 256_L 1.654 1.00
18_R 123_I 1.647 1.00
94_C 97_P 1.639 1.00
150_S 297_C 1.632 1.00
239_T 242_G 1.624 1.00
75_V 139_R 1.619 1.00
174_A 412_L 1.603 1.00
271_Y 295_K 1.602 1.00
166_A 444_L 1.594 1.00
221_T 274_V 1.586 1.00
70_G 137_T 1.586 1.00
45_S 49_S 1.565 1.00
278_A 289_V 1.548 1.00
52_F 69_F 1.542 1.00
216_L 219_T 1.53 1.00
139_R 164_V 1.528 1.00
307_E 399_A 1.512 1.00
42_H 46_A 1.509 1.00
154_F 157_R 1.508 1.00
113_L 172_P 1.502 1.00
16_R 20_T 1.486 1.00
154_F 158_E 1.46 1.00
303_N 306_L 1.452 1.00
314_L 436_T 1.452 1.00
211_L 242_G 1.45 1.00
136_G 445_F 1.447 1.00
162_D 395_K 1.417 1.00
268_Q 272_D 1.415 1.00
269_H 273_R 1.411 1.00
403_S 433_A 1.399 0.99
22_I 42_H 1.393 0.99
238_I 256_L 1.388 0.99
117_A 121_A 1.387 0.99
126_K 129_L 1.383 0.99
11_A 15_D 1.375 0.99
196_I 208_R 1.366 0.99
53_T 70_G 1.365 0.99
161_F 396_L 1.356 0.99
211_L 239_T 1.356 0.99
167_A 396_L 1.351 0.99
46_A 50_A 1.35 0.99
308_N 312_Q 1.348 0.99
117_A 170_W 1.348 0.99
32_T 86_A 1.344 0.99
276_K 283_L 1.332 0.99
10_D 14_A 1.326 0.99
29_H 38_W 1.326 0.99
268_Q 295_K 1.322 0.99
271_Y 293_F 1.317 0.99
38_W 42_H 1.31 0.99
216_L 285_T 1.301 0.99
316_H 439_A 1.299 0.99
276_K 279_E 1.29 0.99
53_T 68_S 1.289 0.99
59_G 158_E 1.279 0.99
191_W 255_V 1.275 0.99
18_R 21_D 1.274 0.99
215_T 219_T 1.272 0.99
315_S 319_T 1.269 0.99
168_L 444_L 1.265 0.99
15_D 18_R 1.263 0.99
191_W 278_A 1.261 0.99
434_A 438_A 1.259 0.99
259_I 293_F 1.247 0.99
82_Y 115_G 1.242 0.98
18_R 46_A 1.24 0.98
52_F 67_A 1.238 0.98
78_L 118_A 1.238 0.98
77_A 141_Y 1.236 0.98
13_E 431_L 1.235 0.98
34_F 145_G 1.229 0.98
48_E 54_V 1.226 0.98
191_W 291_C 1.223 0.98
68_S 137_T 1.222 0.98
37_F 41_E 1.214 0.98
240_N 254_E 1.206 0.98
194_K 251_A 1.203 0.98
189_A 257_Y 1.198 0.98
92_A 97_P 1.196 0.98
169_T 400_Q 1.193 0.98
11_A 127_K 1.185 0.98
52_F 140_F 1.182 0.98
170_W 403_S 1.18 0.98
9_D 435_K 1.177 0.98
12_I 435_K 1.177 0.98
12_I 124_A 1.171 0.98
309_A 313_A 1.168 0.97
315_S 320_P 1.162 0.97
216_L 220_G 1.148 0.97
220_G 277_I 1.145 0.97
309_A 443_N 1.144 0.97
274_V 291_C 1.143 0.97
141_Y 167_A 1.14 0.97
76_I 441_T 1.139 0.97
312_Q 315_S 1.138 0.97
124_A 128_W 1.135 0.97
310_M 401_C 1.132 0.97
280_G 283_L 1.121 0.97
275_A 291_C 1.119 0.96
310_M 440_T 1.118 0.96
11_A 14_A 1.117 0.96
278_A 291_C 1.116 0.96
35_E 105_N 1.111 0.96
218_T 239_T 1.101 0.96
205_H 229_I 1.101 0.96
55_T 68_S 1.096 0.96
45_S 48_E 1.091 0.96
269_H 272_D 1.091 0.96
193_F 213_A 1.084 0.96
33_R 149_G 1.083 0.96
272_D 275_A 1.08 0.95
304_R 308_N 1.078 0.95
33_R 148_G 1.073 0.95
16_R 428_K 1.053 0.95
13_E 16_R 1.048 0.94
180_N 308_N 1.046 0.94
305_T 308_N 1.045 0.94
190_S 246_P 1.038 0.94
259_I 274_V 1.037 0.94
21_D 25_Q 1.036 0.94
231_K 263_E 1.033 0.94
170_W 433_A 1.026 0.94
218_T 255_V 1.024 0.93
120_A 434_A 1.023 0.93
26_I 115_G 1.02 0.93
212_D 218_T 1.019 0.93
50_A 123_I 1.018 0.93
221_T 234_V 1.017 0.93
168_L 306_L 1.016 0.93
240_N 244_I 1.014 0.93
139_R 163_D 1.01 0.93
276_K 280_G 1.01 0.93
261_A 270_I 1.008 0.93
189_A 274_V 1.005 0.93
281_A 284_M 1.004 0.93
300_Y 390_G 1.002 0.92
313_A 440_T 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ramA40.80671000.416Contact Map0.726
3io1A20.81081000.456Contact Map0.704
4ewtA40.77751000.473Contact Map0.802
3pfoA20.77551000.481Contact Map0.63
1xmbA10.80041000.489Contact Map0.717
1ysjA20.78381000.494Contact Map0.757
1cg2A40.77961000.508Contact Map0.604
3dljA20.78381000.509Contact Map0.562
2zogA20.78381000.511Contact Map0.589
4g1pA10.80251000.511Contact Map0.65

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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