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CURA - NADPH-dependent curcumin reductase
UniProt: P76113 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13772
Length: 345 (325)
Sequences: 22451
Seq/Len: 69.08

CURA
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
320_N 323_Q 3.434 1.00
44_R 83_V 3.112 1.00
41_V 113_L 2.958 1.00
46_V 81_R 2.889 1.00
42_L 83_V 2.765 1.00
171_K 197_D 2.737 1.00
14_A 29_E 2.708 1.00
94_D 115_K 2.707 1.00
152_T 176_R 2.695 1.00
46_V 122_N 2.642 1.00
316_D 327_G 2.581 1.00
91_Q 94_D 2.516 1.00
210_Q 213_K 2.487 1.00
95_W 116_L 2.434 1.00
187_C 191_T 2.42 1.00
44_R 105_Y 2.335 1.00
44_R 81_R 2.321 1.00
176_R 198_V 2.303 1.00
301_Q 305_E 2.275 1.00
188_R 193_V 2.269 1.00
153_L 170_G 2.237 1.00
317_G 320_N 2.222 1.00
33_V 105_Y 2.218 1.00
89_D 110_G 2.203 1.00
14_A 27_R 2.191 1.00
184_A 188_R 2.12 1.00
315_T 340_R 2.105 1.00
12_V 29_E 2.1 1.00
148_K 151_E 2.092 1.00
314_I 327_G 2.053 1.00
37_G 40_Q 2.053 1.00
119_H 304_K 2.046 1.00
154_V 219_I 2.039 1.00
35_T 84_E 2.032 1.00
167_G 196_F 2.007 1.00
78_T 101_G 2.005 1.00
42_L 107_I 1.987 1.00
323_Q 326_I 1.967 1.00
326_I 330_K 1.952 1.00
151_E 243_R 1.94 1.00
238_L 244_I 1.924 1.00
316_D 324_T 1.921 1.00
134_G 165_T 1.908 1.00
154_V 180_V 1.885 1.00
121_Q 124_S 1.876 1.00
158_A 179_G 1.874 1.00
184_A 201_D 1.834 1.00
327_G 332_K 1.812 1.00
79_V 122_N 1.803 1.00
83_V 105_Y 1.786 1.00
142_L 173_K 1.766 1.00
181_A 187_C 1.758 1.00
243_R 278_R 1.735 1.00
187_C 199_C 1.73 1.00
220_D 239_N 1.717 1.00
188_R 191_T 1.71 1.00
84_E 92_S 1.7 1.00
90_Y 115_K 1.697 1.00
205_D 210_Q 1.693 1.00
36_P 107_I 1.679 1.00
189_H 193_V 1.677 1.00
123_P 315_T 1.675 1.00
9_R 30_E 1.668 1.00
59_S 329_L 1.666 1.00
95_W 118_D 1.662 1.00
243_R 280_Q 1.659 1.00
323_Q 327_G 1.645 1.00
172_L 307_K 1.641 1.00
9_R 104_D 1.641 1.00
206_D 209_E 1.619 1.00
238_L 242_A 1.611 1.00
40_Q 109_S 1.605 1.00
238_L 277_I 1.602 1.00
78_T 98_G 1.598 1.00
201_D 204_A 1.593 1.00
178_V 219_I 1.589 1.00
156_A 234_V 1.576 1.00
39_G 109_S 1.563 1.00
11_W 321_A 1.559 1.00
222_Y 234_V 1.537 1.00
198_V 214_A 1.531 1.00
184_A 204_A 1.529 1.00
95_W 122_N 1.526 1.00
85_S 92_S 1.522 1.00
42_L 105_Y 1.514 1.00
90_Y 94_D 1.508 1.00
102_W 325_F 1.504 1.00
40_Q 107_I 1.487 1.00
81_R 95_W 1.477 1.00
47_Y 340_R 1.467 1.00
9_R 319_E 1.466 1.00
82_V 90_Y 1.458 1.00
176_R 197_D 1.456 1.00
41_V 90_Y 1.45 1.00
145_G 221_I 1.445 1.00
116_L 122_N 1.431 1.00
45_T 78_T 1.41 1.00
42_L 84_E 1.408 1.00
36_P 42_L 1.402 0.99
36_P 40_Q 1.386 0.99
322_P 326_I 1.377 0.99
167_G 179_G 1.371 0.99
10_R 31_D 1.36 0.99
313_E 327_G 1.357 0.99
121_Q 125_W 1.354 0.99
222_Y 238_L 1.353 0.99
152_T 178_V 1.345 0.99
301_Q 304_K 1.344 0.99
166_V 223_Y 1.32 0.99
182_G 202_H 1.313 0.99
209_E 213_K 1.303 0.99
90_Y 113_L 1.297 0.99
159_T 179_G 1.295 0.99
156_A 180_V 1.278 0.99
46_V 95_W 1.276 0.99
318_L 341_V 1.254 0.99
147_P 175_C 1.25 0.99
39_G 110_G 1.244 0.98
108_S 113_L 1.244 0.98
47_Y 123_P 1.235 0.98
145_G 245_P 1.221 0.98
11_W 28_L 1.221 0.98
123_P 340_R 1.219 0.98
43_L 80_S 1.215 0.98
50_L 324_T 1.206 0.98
116_L 127_L 1.202 0.98
20_A 24_E 1.2 0.98
184_A 187_C 1.187 0.98
179_G 196_F 1.183 0.98
152_T 220_D 1.18 0.98
81_R 122_N 1.173 0.98
142_L 298_E 1.172 0.98
138_Y 142_L 1.162 0.97
302_W 307_K 1.162 0.97
33_V 42_L 1.158 0.97
172_L 302_W 1.158 0.97
210_Q 214_A 1.128 0.97
182_G 203_H 1.112 0.96
28_L 319_E 1.108 0.96
45_T 106_D 1.107 0.96
155_V 166_V 1.103 0.96
224_E 227_G 1.071 0.95
38_E 86_N 1.069 0.95
191_T 199_C 1.069 0.95
7_R 30_E 1.053 0.95
297_R 301_Q 1.052 0.95
151_E 220_D 1.052 0.95
298_E 301_Q 1.052 0.95
321_A 339_I 1.044 0.94
326_I 329_L 1.041 0.94
317_G 340_R 1.029 0.94
137_A 169_I 1.029 0.94
124_S 315_T 1.027 0.94
134_G 299_M 1.019 0.93
155_V 170_G 1.016 0.93
43_L 96_V 1.013 0.93
44_R 104_D 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4j6fA20.9131000.119Contact Map0.77
4gi2A20.9421000.123Contact Map0.819
4dupA20.93621000.13Contact Map0.81
3uogA20.90721000.134Contact Map0.818
1yb5A20.92751000.136Contact Map0.84
1zsyA10.93331000.138Contact Map0.748
4eyeA20.92461000.142Contact Map0.796
4a27A20.94781000.143Contact Map0.824
1f8fA10.90721000.145Contact Map0.814
3nx4A20.90431000.151Contact Map0.727

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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