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CLCB - Voltage-gated ClC-type chloride channel ClcB
UniProt: P76175 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13848
Length: 418 (414)
Sequences: 2668
Seq/Len: 6.44

CLCB
Paralog alert: 0.56 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: CLCA CLCB YFEO
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
361_T 393_A 4.022 1.00
299_A 335_L 3.329 1.00
115_S 312_S 3.117 1.00
127_A 151_G 3.066 1.00
116_A 309_V 3.024 1.00
110_V 115_S 2.787 1.00
116_A 305_K 2.724 1.00
117_I 312_S 2.69 1.00
220_D 354_L 2.671 1.00
357_T 393_A 2.623 1.00
168_L 375_L 2.41 1.00
230_L 332_I 2.308 1.00
240_T 244_A 2.251 1.00
79_P 82_P 2.215 1.00
227_T 336_Y 2.133 1.00
18_A 130_A 2.079 1.00
234_C 362_L 2.047 1.00
224_I 357_T 2.009 1.00
135_A 144_W 1.984 1.00
189_S 193_A 1.958 1.00
302_F 328_I 1.938 1.00
110_V 117_I 1.919 1.00
232_G 401_S 1.856 1.00
228_G 232_G 1.833 1.00
266_I 311_A 1.827 1.00
19_V 123_M 1.819 1.00
270_L 308_A 1.787 1.00
285_V 330_L 1.763 1.00
29_L 112_T 1.758 1.00
28_L 32_L 1.74 1.00
183_L 187_I 1.705 1.00
244_A 248_G 1.7 1.00
271_S 278_W 1.682 1.00
264_G 268_G 1.675 1.00
60_G 113_S 1.674 1.00
231_A 332_I 1.666 1.00
228_G 397_A 1.651 1.00
245_C 314_G 1.649 1.00
61_G 65_G 1.635 1.00
24_H 28_L 1.631 1.00
244_A 247_R 1.63 1.00
232_G 400_I 1.626 1.00
11_V 147_W 1.609 1.00
110_V 317_A 1.584 1.00
363_L 367_T 1.58 0.99
81_A 84_D 1.575 0.99
20_A 200_I 1.56 0.99
325_T 366_T 1.544 0.99
225_I 229_V 1.543 0.99
238_L 309_V 1.529 0.99
233_L 237_L 1.523 0.99
88_A 91_T 1.521 0.99
222_A 226_S 1.514 0.99
149_A 175_F 1.511 0.99
364_A 394_C 1.51 0.99
249_F 315_S 1.508 0.99
169_F 173_V 1.499 0.99
154_A 189_S 1.497 0.99
235_G 365_A 1.492 0.99
302_F 335_L 1.491 0.99
110_V 312_S 1.488 0.99
65_G 260_L 1.462 0.99
295_L 335_L 1.46 0.99
79_P 83_T 1.454 0.99
234_C 332_I 1.45 0.99
225_I 396_I 1.437 0.99
368_H 402_R 1.432 0.99
258_W 261_A 1.43 0.99
103_K 318_P 1.427 0.99
122_A 160_Y 1.418 0.99
13_I 196_V 1.416 0.99
13_I 17_F 1.415 0.99
22_F 107_S 1.409 0.99
229_V 396_I 1.404 0.99
339_S 343_W 1.399 0.98
14_L 130_A 1.399 0.98
277_V 308_A 1.397 0.98
17_F 200_I 1.394 0.98
326_L 359_M 1.392 0.98
153_A 170_I 1.392 0.98
33_F 113_S 1.387 0.98
86_M 89_L 1.369 0.98
223_L 340_L 1.366 0.98
103_K 155_G 1.366 0.98
104_S 126_L 1.363 0.98
298_I 335_L 1.353 0.98
164_L 375_L 1.351 0.98
288_F 331_A 1.344 0.98
368_H 401_S 1.335 0.98
365_A 397_A 1.331 0.98
19_V 158_A 1.33 0.98
261_A 265_L 1.329 0.98
93_G 132_S 1.322 0.98
306_L 328_I 1.321 0.98
363_L 373_S 1.32 0.98
229_V 400_I 1.318 0.98
302_F 331_A 1.312 0.97
82_P 85_Y 1.308 0.97
87_E 90_Q 1.304 0.97
149_A 186_V 1.303 0.97
374_T 391_L 1.301 0.97
249_F 263_G 1.297 0.97
66_L 70_G 1.292 0.97
153_A 157_A 1.284 0.97
390_L 394_C 1.283 0.97
187_I 395_V 1.283 0.97
241_L 310_L 1.269 0.97
367_T 380_M 1.261 0.97
281_G 327_F 1.26 0.97
398_S 402_R 1.258 0.96
155_G 232_G 1.248 0.96
106_A 318_P 1.247 0.96
103_K 122_A 1.238 0.96
231_A 362_L 1.237 0.96
71_W 74_F 1.235 0.96
227_T 231_A 1.234 0.96
133_C 137_R 1.233 0.96
25_A 108_L 1.232 0.96
245_C 310_L 1.232 0.96
377_I 390_L 1.231 0.96
57_P 60_G 1.228 0.96
236_P 401_S 1.224 0.96
224_I 393_A 1.214 0.95
14_L 18_A 1.211 0.95
159_A 173_V 1.201 0.95
238_L 312_S 1.201 0.95
336_Y 340_L 1.199 0.95
173_V 313_S 1.197 0.95
284_T 327_F 1.186 0.95
136_Q 144_W 1.185 0.95
115_S 317_A 1.184 0.95
180_L 183_L 1.183 0.95
16_A 20_A 1.178 0.94
150_C 189_S 1.176 0.94
360_A 394_C 1.169 0.94
84_D 156_M 1.169 0.94
302_F 332_I 1.161 0.94
123_M 323_T 1.158 0.94
393_A 397_A 1.155 0.94
58_A 261_A 1.152 0.93
27_L 31_W 1.149 0.93
188_I 192_V 1.145 0.93
3_H 143_E 1.142 0.93
186_V 190_A 1.141 0.93
6_L 10_V 1.139 0.93
249_F 252_L 1.139 0.93
67_L 70_G 1.136 0.93
298_I 334_M 1.134 0.93
269_L 273_F 1.133 0.93
146_L 185_P 1.132 0.93
13_I 199_L 1.129 0.93
180_L 191_V 1.124 0.92
182_S 186_V 1.121 0.92
80_H 83_T 1.119 0.92
269_L 272_L 1.112 0.92
231_A 365_A 1.109 0.92
134_F 138_F 1.096 0.91
237_L 306_L 1.095 0.91
167_S 187_I 1.086 0.91
298_I 331_A 1.085 0.90
108_L 112_T 1.081 0.90
81_A 85_Y 1.08 0.90
14_L 134_F 1.079 0.90
372_M 376_M 1.079 0.90
152_A 174_L 1.077 0.90
63_A 109_L 1.07 0.90
306_L 310_L 1.069 0.90
378_C 387_L 1.068 0.90
407_D 415_A 1.063 0.89
232_G 397_A 1.062 0.89
334_M 355_G 1.061 0.89
117_I 319_G 1.059 0.89
139_T 143_E 1.057 0.89
103_K 121_G 1.057 0.89
330_L 355_G 1.057 0.89
119_R 125_L 1.056 0.89
100_S 129_L 1.056 0.89
218_A 221_Y 1.053 0.89
329_G 333_G 1.049 0.88
309_V 328_I 1.049 0.88
263_G 315_S 1.049 0.88
9_T 192_V 1.047 0.88
233_L 400_I 1.047 0.88
235_G 366_T 1.038 0.88
81_A 121_G 1.037 0.88
123_M 372_M 1.035 0.87
10_V 13_I 1.03 0.87
356_L 381_T 1.03 0.87
325_T 362_L 1.028 0.87
21_G 104_S 1.026 0.87
223_L 336_Y 1.025 0.87
396_I 400_I 1.023 0.87
201_N 205_A 1.019 0.86
117_I 313_S 1.019 0.86
79_P 87_E 1.018 0.86
64_A 317_A 1.016 0.86
231_A 361_T 1.011 0.86
51_W 55_L 1.009 0.86
12_G 16_A 1.008 0.86
87_E 91_T 1.006 0.85
23_R 119_R 1.002 0.85
15_A 127_A 1.001 0.85
80_H 84_D 1.001 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nd0A20.98091000.095Contact Map0.685
4eneA20.98091000.1Contact Map0.708
3orgA40.97131000.19Contact Map0.626
1jcnA20.2225990.866Contact Map0.002
3usbA20.2081900.943Contact Map0
4avfA40.172228.30.965Contact Map0
2ksfA10.23688.30.972Contact Map0.271
4b19A10.07185.30.975Contact Map0.52
3llqA20.16994.90.975Contact Map0.425
1vrdA20.19144.50.976Contact Map0

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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