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ASTD - N-succinylglutamate 5-semialdehyde dehydrogenase
UniProt: P76217 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13997
Length: 492 (467)
Sequences: 17623
Seq/Len: 37.74

ASTD
Paralog alert: 0.85 [within 20: 0.23] - ratio of genomes with paralogs
Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
287_S 387_D 5.447 1.00
230_R 235_Q 3.584 1.00
287_S 385_R 3.237 1.00
259_D 297_R 3.133 1.00
254_E 286_K 2.86 1.00
73_E 106_A 2.806 1.00
366_T 369_A 2.799 1.00
324_E 328_Q 2.785 1.00
47_R 212_D 2.74 1.00
18_V 30_Q 2.729 1.00
290_Q 385_R 2.687 1.00
335_Q 339_A 2.672 1.00
254_E 288_G 2.611 1.00
336_Q 370_G 2.579 1.00
263_H 301_V 2.575 1.00
295_L 383_V 2.563 1.00
349_R 359_T 2.55 1.00
75_N 78_E 2.494 1.00
179_A 182_R 2.472 1.00
334_W 358_L 2.429 1.00
321_L 330_V 2.427 1.00
6_N 48_A 2.411 1.00
409_S 415_F 2.343 1.00
47_R 214_D 2.28 1.00
299_V 303_Q 2.166 1.00
185_Q 191_P 2.159 1.00
18_V 27_V 2.141 1.00
35_D 38_Q 2.128 1.00
417_Q 421_E 2.124 1.00
389_F 417_Q 2.115 1.00
343_R 364_E 2.088 1.00
68_F 184_W 2.07 1.00
389_F 414_K 2.039 1.00
76_K 99_T 1.998 1.00
284_L 392_A 1.968 1.00
3_L 34_A 1.956 1.00
296_A 300_A 1.951 1.00
331_V 335_Q 1.94 1.00
64_V 189_L 1.936 1.00
293_A 297_R 1.901 1.00
44_R 212_D 1.893 1.00
283_L 381_L 1.893 1.00
172_L 323_S 1.891 1.00
338_E 344_P 1.886 1.00
336_Q 340_M 1.882 1.00
4_W 185_Q 1.876 1.00
71_L 186_Q 1.857 1.00
250_L 265_T 1.838 1.00
70_A 74_S 1.82 1.00
400_R 447_A 1.812 1.00
71_L 74_S 1.807 1.00
345_L 363_I 1.801 1.00
133_R 465_P 1.8 1.00
132_H 462_C 1.794 1.00
105_I 156_V 1.789 1.00
370_G 374_E 1.787 1.00
209_A 231_Q 1.777 1.00
331_V 358_L 1.774 1.00
71_L 183_L 1.766 1.00
40_E 44_R 1.751 1.00
205_Q 209_A 1.749 1.00
331_V 350_L 1.738 1.00
255_V 414_K 1.732 1.00
70_A 106_A 1.731 1.00
302_S 362_I 1.73 1.00
50_F 54_A 1.724 1.00
40_E 206_A 1.721 1.00
387_D 391_E 1.72 1.00
75_N 186_Q 1.715 1.00
78_E 179_A 1.714 1.00
77_A 95_A 1.713 1.00
292_D 385_R 1.702 1.00
226_Y 447_A 1.686 1.00
390_D 421_E 1.682 1.00
284_L 395_M 1.671 1.00
391_E 394_R 1.669 1.00
423_R 446_G 1.659 1.00
299_V 345_L 1.653 1.00
181_M 196_L 1.647 1.00
254_E 414_K 1.645 1.00
367_G 395_M 1.628 1.00
290_Q 295_L 1.614 1.00
66_E 106_A 1.606 1.00
77_A 81_A 1.6 1.00
71_L 187_A 1.597 1.00
405_C 424_A 1.595 1.00
82_I 179_A 1.575 1.00
227_Q 230_R 1.575 1.00
8_D 191_P 1.57 1.00
286_K 386_Y 1.568 1.00
293_A 296_A 1.564 1.00
164_T 193_V 1.559 1.00
301_V 304_R 1.546 1.00
132_H 459_A 1.534 1.00
372_P 384_W 1.531 1.00
73_E 102_I 1.528 1.00
264_L 408_V 1.527 1.00
265_T 294_F 1.505 1.00
67_R 70_A 1.504 1.00
393_I 418_L 1.504 1.00
286_K 388_T 1.5 1.00
57_S 60_E 1.486 1.00
388_T 391_E 1.485 1.00
40_E 210_L 1.478 1.00
258_I 297_R 1.476 1.00
343_R 363_I 1.47 1.00
335_Q 338_E 1.443 1.00
60_E 63_A 1.443 1.00
306_T 314_P 1.434 1.00
328_Q 332_T 1.433 1.00
297_R 300_A 1.431 1.00
332_T 370_G 1.423 1.00
50_F 164_T 1.399 0.99
285_L 294_F 1.389 0.99
27_V 30_Q 1.387 0.99
253_D 414_K 1.387 0.99
55_R 421_E 1.384 0.99
20_R 27_V 1.38 0.99
300_A 304_R 1.367 0.99
270_F 302_S 1.365 0.99
262_V 297_R 1.35 0.99
43_C 210_L 1.349 0.99
265_T 283_L 1.346 0.99
111_A 114_V 1.346 0.99
81_A 85_R 1.337 0.99
182_R 186_Q 1.334 0.99
327_A 331_V 1.331 0.99
69_A 106_A 1.331 0.99
253_D 386_Y 1.331 0.99
300_A 303_Q 1.329 0.99
79_L 179_A 1.325 0.99
10_I 41_Q 1.325 0.99
140_V 165_I 1.324 0.99
333_A 376_V 1.311 0.99
81_A 311_D 1.31 0.99
131_R 420_L 1.31 0.99
305_L 318_I 1.298 0.99
105_I 152_N 1.29 0.99
340_M 370_G 1.289 0.99
21_N 24_S 1.289 0.99
327_A 358_L 1.282 0.99
184_W 194_L 1.28 0.99
391_E 395_M 1.276 0.99
309_N 312_D 1.274 0.99
44_R 48_A 1.273 0.99
390_D 417_Q 1.267 0.99
290_Q 363_I 1.266 0.99
303_Q 346_L 1.266 0.99
39_V 203_T 1.263 0.99
229_H 450_N 1.261 0.99
68_F 183_L 1.253 0.99
84_A 94_A 1.252 0.99
68_F 105_I 1.248 0.99
284_L 386_Y 1.244 0.98
26_E 355_T 1.243 0.98
67_R 71_L 1.239 0.98
250_L 280_A 1.233 0.98
215_G 241_A 1.232 0.98
151_P 167_F 1.221 0.98
56_L 60_E 1.218 0.98
205_Q 227_Q 1.217 0.98
373_D 398_N 1.216 0.98
205_Q 231_Q 1.214 0.98
69_A 73_E 1.213 0.98
38_Q 41_Q 1.208 0.98
324_E 327_A 1.205 0.98
253_D 418_L 1.204 0.98
75_N 179_A 1.197 0.98
79_L 183_L 1.195 0.98
131_R 467_A 1.193 0.98
29_W 175_W 1.186 0.98
181_M 194_L 1.183 0.98
140_V 217_L 1.18 0.98
75_N 183_L 1.179 0.98
393_I 397_N 1.173 0.98
386_Y 395_M 1.17 0.97
4_W 9_W 1.164 0.97
227_Q 231_Q 1.161 0.97
393_I 421_E 1.161 0.97
155_I 194_L 1.154 0.97
373_D 400_R 1.152 0.97
330_V 378_G 1.147 0.97
21_N 309_N 1.141 0.97
419_L 467_A 1.141 0.97
43_C 212_D 1.129 0.97
66_E 113_H 1.127 0.97
405_C 427_V 1.126 0.97
251_I 392_A 1.122 0.97
368_V 373_D 1.119 0.96
292_D 296_A 1.115 0.96
118_E 457_Y 1.115 0.96
84_A 310_W 1.113 0.96
129_S 469_L 1.112 0.96
294_F 298_L 1.108 0.96
295_L 299_V 1.1 0.96
68_F 189_L 1.098 0.96
299_V 346_L 1.096 0.96
16_S 30_Q 1.094 0.96
251_I 418_L 1.093 0.96
118_E 456_W 1.093 0.96
392_A 395_M 1.093 0.96
132_H 464_W 1.092 0.96
298_L 381_L 1.091 0.96
295_L 345_L 1.086 0.96
129_S 416_D 1.082 0.96
411_E 414_K 1.082 0.96
224_T 227_Q 1.082 0.96
367_G 398_N 1.077 0.95
389_F 418_L 1.071 0.95
74_S 186_Q 1.07 0.95
139_A 213_L 1.068 0.95
45_A 192_G 1.063 0.95
56_L 64_V 1.057 0.95
347_A 361_G 1.057 0.95
452_R 463_A 1.056 0.95
249_P 405_C 1.054 0.95
229_H 240_L 1.054 0.95
253_D 286_K 1.052 0.95
336_Q 339_A 1.052 0.95
390_D 394_R 1.05 0.94
25_G 355_T 1.046 0.94
137_V 213_L 1.045 0.94
91_R 95_A 1.045 0.94
289_A 293_A 1.044 0.94
286_K 289_A 1.041 0.94
135_H 163_N 1.036 0.94
303_Q 359_T 1.035 0.94
327_A 350_L 1.033 0.94
292_D 295_L 1.031 0.94
206_A 210_L 1.03 0.94
139_A 207_L 1.029 0.94
226_Y 237_E 1.029 0.94
51_P 394_R 1.027 0.94
255_V 411_E 1.025 0.93
456_W 459_A 1.025 0.93
221_S 224_T 1.025 0.93
257_D 410_P 1.021 0.93
146_F 276_R 1.02 0.93
332_T 336_Q 1.02 0.93
306_T 316_P 1.019 0.93
340_M 369_A 1.018 0.93
81_A 91_R 1.017 0.93
253_D 389_F 1.016 0.93
21_N 85_R 1.012 0.93
6_N 45_A 1.011 0.93
308_G 315_Q 1.01 0.93
171_E 201_R 1.009 0.93
204_G 208_S 1.007 0.93
330_V 380_L 1.004 0.93
66_E 110_K 1.002 0.92
76_K 95_A 1.001 0.92
13_Q 35_D 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i8pA20.97561000.065Contact Map0.784
1a4sA40.96341000.068Contact Map0.791
3ek1A80.94721000.072Contact Map0.809
4lihA80.94721000.075Contact Map0.782
4i9bA20.97561000.075Contact Map0.756
4f3xA40.94511000.076Contact Map0.722
3ed6A20.96951000.076Contact Map0.783
1o04A80.95931000.076Contact Map0.823
3k2wA80.96751000.077Contact Map0.862
1bxsA40.95731000.077Contact Map0.82

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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