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CMOA - tRNA (cmo5U34)-methyltransferase
UniProt: P76290 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14033
Length: 247 (226)
Sequences: 2773
Seq/Len: 12.27

CMOA
Paralog alert: 0.53 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: BIOC CMOA SMTA TAM TEHB UBIE UBIG YAFE YJHP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
151_Y 223_F 3.248 1.00
144_Q 220_N 3.083 1.00
149_K 152_Q 3.014 1.00
61_Y 126_A 2.836 1.00
150_I 160_L 2.807 1.00
59_Q 84_K 2.793 1.00
92_P 96_E 2.768 1.00
95_I 115_E 2.751 1.00
29_P 67_L 2.697 1.00
92_P 115_E 2.644 1.00
127_S 155_N 2.617 1.00
215_K 219_H 2.614 1.00
86_I 126_A 2.554 1.00
65_C 87_A 2.509 1.00
64_G 134_T 2.501 1.00
95_I 113_V 2.45 1.00
119_R 142_E 2.275 1.00
210_S 213_T 2.228 1.00
84_K 112_D 2.166 1.00
144_Q 217_R 2.128 1.00
144_Q 148_D 2.097 1.00
102_I 113_V 2.093 1.00
29_P 101_H 2.059 1.00
97_R 100_R 2.011 1.00
93_A 96_E 1.996 1.00
154_L 158_G 1.909 1.00
154_L 160_L 1.882 1.00
149_K 153_G 1.873 1.00
88_I 116_G 1.864 1.00
151_Y 242_K 1.825 1.00
64_G 131_L 1.816 1.00
87_A 113_V 1.772 1.00
69_A 101_H 1.752 1.00
86_I 114_I 1.737 1.00
72_L 102_I 1.733 1.00
138_L 146_L 1.729 1.00
129_V 150_I 1.71 1.00
71_T 85_I 1.695 1.00
216_A 220_N 1.657 1.00
50_A 128_M 1.643 1.00
22_E 93_A 1.638 1.00
117_D 120_D 1.613 1.00
59_Q 86_I 1.584 1.00
129_V 153_G 1.555 1.00
65_C 71_T 1.555 1.00
121_I 153_G 1.534 1.00
76_R 105_Y 1.517 1.00
144_Q 221_A 1.517 1.00
123_I 126_A 1.506 1.00
122_A 149_K 1.493 1.00
88_I 121_I 1.48 1.00
118_I 134_T 1.47 1.00
218_L 240_A 1.462 1.00
71_T 111_V 1.45 1.00
71_T 87_A 1.433 1.00
129_V 154_L 1.427 1.00
99_R 103_D 1.418 1.00
148_D 220_N 1.379 0.99
216_A 219_H 1.37 0.99
116_G 122_A 1.368 0.99
86_I 112_D 1.362 0.99
135_L 147_L 1.358 0.99
154_L 223_F 1.329 0.99
63_L 118_I 1.322 0.99
63_L 150_I 1.292 0.99
145_A 148_D 1.269 0.99
160_L 223_F 1.264 0.99
141_S 213_T 1.256 0.99
121_I 149_K 1.243 0.98
40_S 73_S 1.232 0.98
60_V 128_M 1.229 0.98
67_L 97_R 1.207 0.98
211_V 228_L 1.197 0.98
160_L 218_L 1.186 0.98
96_E 99_R 1.173 0.98
60_V 74_V 1.171 0.98
218_L 223_F 1.167 0.97
136_Q 164_E 1.162 0.97
224_E 243_A 1.16 0.97
98_C 113_V 1.143 0.97
131_L 160_L 1.141 0.97
67_L 101_H 1.134 0.97
132_N 163_S 1.118 0.96
59_Q 155_N 1.112 0.96
147_L 160_L 1.108 0.96
211_V 215_K 1.104 0.96
126_A 153_G 1.095 0.96
151_Y 154_L 1.091 0.96
89_D 95_I 1.086 0.96
26_E 97_R 1.086 0.96
123_I 153_G 1.082 0.96
133_F 137_F 1.08 0.95
26_E 100_R 1.07 0.95
87_A 98_C 1.066 0.95
68_G 98_C 1.059 0.95
46_I 132_N 1.054 0.95
47_G 77_N 1.053 0.95
69_A 73_S 1.045 0.94
137_F 206_M 1.024 0.93
22_E 91_S 1.021 0.93
136_Q 206_M 1.02 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gekA211000.325Contact Map0.781
3dtnA20.92711000.429Contact Map0.807
3bxoA20.87451000.46Contact Map0.797
1y8cA10.88261000.47Contact Map0.766
3pfgA10.93121000.48Contact Map0.82
1wznA30.87451000.492Contact Map0.824
4htfA10.931299.90.497Contact Map0.723
4hgzA60.963699.90.497Contact Map0.835
3hnrA10.866499.90.499Contact Map0.736
2o57A40.890799.90.5Contact Map0.793

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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