GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
ATOD - Acetate CoA-transferase subunit alpha
UniProt: P76458 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11669
Length: 220 (218)
Sequences: 1580
Seq/Len: 7.25

ATOD
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
161_T 194_E 3.685 1.00
135_T 140_T 3.483 1.00
120_P 139_K 3.422 1.00
165_L 187_V 3.311 1.00
198_L 203_I 3.17 1.00
156_A 165_L 3.137 1.00
16_R 19_M 2.999 1.00
167_Y 205_T 2.907 1.00
137_D 145_R 2.783 1.00
83_E 86_R 2.737 1.00
71_R 94_D 2.594 1.00
17_D 45_R 2.574 1.00
22_M 149_A 2.521 1.00
158_R 191_E 2.45 1.00
58_D 66_V 2.403 1.00
7_T 10_D 2.366 1.00
9_Q 41_E 2.305 1.00
18_G 46_D 2.245 1.00
46_D 71_R 2.176 1.00
22_M 107_I 2.174 1.00
123_V 140_T 2.159 1.00
133_T 140_T 2.119 1.00
15_F 39_L 2.118 1.00
157_H 168_Q 2.09 1.00
37_E 63_P 2.077 1.00
38_A 41_E 1.969 1.00
48_T 74_I 1.905 1.00
50_I 147_L 1.889 1.00
39_L 153_L 1.852 1.00
86_R 90_S 1.842 1.00
161_T 195_T 1.837 1.00
68_G 87_R 1.824 1.00
118_L 134_L 1.823 1.00
87_R 92_E 1.779 1.00
159_C 189_P 1.768 1.00
159_C 192_L 1.734 1.00
50_I 149_A 1.713 1.00
159_C 187_V 1.689 1.00
158_R 166_T 1.664 1.00
152_A 182_A 1.635 1.00
15_F 186_L 1.601 1.00
23_V 153_L 1.594 1.00
162_L 195_T 1.588 1.00
148_R 183_D 1.556 1.00
194_E 197_E 1.555 1.00
64_L 69_R 1.547 1.00
96_V 106_Q 1.542 1.00
17_D 43_G 1.537 1.00
10_D 13_G 1.536 1.00
133_T 142_L 1.517 0.99
68_G 92_E 1.517 0.99
116_G 143_L 1.516 0.99
199_Q 202_H 1.512 0.99
107_I 178_I 1.499 0.99
19_M 151_L 1.494 0.99
105_E 108_R 1.48 0.99
160_D 164_N 1.478 0.99
14_F 212_H 1.465 0.99
35_L 153_L 1.462 0.99
48_T 72_K 1.456 0.99
6_M 10_D 1.45 0.99
72_K 94_D 1.426 0.99
40_L 69_R 1.414 0.99
22_M 178_I 1.413 0.99
110_G 148_R 1.4 0.99
192_L 215_V 1.377 0.99
161_T 197_E 1.346 0.98
20_T 50_I 1.318 0.98
15_F 19_M 1.311 0.98
114_L 117_F 1.31 0.98
184_I 212_H 1.299 0.98
98_V 106_Q 1.298 0.98
8_L 38_A 1.293 0.98
179_A 185_T 1.268 0.97
132_Q 137_D 1.265 0.97
12_T 38_A 1.265 0.97
15_F 151_L 1.264 0.97
44_V 69_R 1.262 0.97
6_M 212_H 1.247 0.97
72_K 96_V 1.245 0.97
106_Q 146_P 1.23 0.97
126_V 129_E 1.214 0.96
191_E 197_E 1.208 0.96
40_L 63_P 1.194 0.96
118_L 143_L 1.183 0.96
115_G 136_L 1.182 0.96
155_R 216_S 1.18 0.96
169_L 201_D 1.179 0.95
12_T 15_F 1.178 0.95
151_L 184_I 1.175 0.95
65_I 87_R 1.175 0.95
107_I 181_A 1.137 0.94
109_C 117_F 1.127 0.94
108_R 112_A 1.12 0.94
34_R 216_S 1.108 0.93
102_T 119_T 1.108 0.93
135_T 138_G 1.108 0.93
9_Q 38_A 1.094 0.93
172_R 201_D 1.094 0.93
40_L 66_V 1.082 0.92
22_M 50_I 1.079 0.92
178_I 182_A 1.059 0.91
154_I 178_I 1.041 0.90
184_I 187_V 1.02 0.89
116_G 134_L 1.005 0.88
67_N 92_E 1.002 0.87
105_E 117_F 1.002 0.87
158_R 193_V 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cdkA211000.203Contact Map0.863
3rrlA211000.206Contact Map0.773
1k6dA211000.209Contact Map0.805
3k6mA40.99551000.211Contact Map0.871
4kgbA211000.217Contact Map0.833
1poiA20.96821000.24Contact Map0.772
2ahuA411000.252Contact Map0.799
2hj0A20.81821000.508Contact Map0.635
3qliA20.83641000.521Contact Map0.606
1xr4A20.80911000.521Contact Map0.643

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0321 seconds.