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ATOA - Acetate CoA-transferase subunit beta
UniProt: P76459 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11670
Length: 216 (213)
Sequences: 1518
Seq/Len: 7.13

ATOA
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
152_R 200_E 4.036 1.00
104_D 108_N 3.662 1.00
80_D 83_M 3.478 1.00
143_A 147_S 3.385 1.00
166_M 175_R 3.384 1.00
193_A 197_A 3.352 1.00
174_F 203_F 3.331 1.00
105_E 152_R 3.28 1.00
150_I 181_M 2.904 1.00
177_I 180_K 2.764 1.00
183_L 205_V 2.607 1.00
186_I 192_L 2.574 1.00
175_R 184_T 2.482 1.00
186_I 195_V 2.417 1.00
55_V 68_Q 2.41 1.00
194_T 198_K 2.392 1.00
177_I 182_W 2.384 1.00
176_F 181_M 2.297 1.00
72_V 78_M 2.213 1.00
206_A 209_L 2.208 1.00
171_L 190_C 2.181 1.00
72_V 76_A 2.164 1.00
171_L 198_K 2.11 1.00
183_L 192_L 2.093 1.00
167_L 176_F 2.076 1.00
106_E 153_R 2.028 1.00
141_H 199_T 2.009 1.00
10_R 185_E 2 1.00
49_F 72_V 1.983 1.00
192_L 196_R 1.978 1.00
192_L 205_V 1.93 1.00
11_V 138_A 1.928 1.00
5_Q 34_Y 1.911 1.00
182_W 204_E 1.837 1.00
94_D 133_R 1.686 1.00
16_R 19_D 1.678 1.00
11_V 168_V 1.663 1.00
7_I 138_A 1.634 1.00
148_A 200_E 1.628 1.00
19_D 95_A 1.608 1.00
102_Q 155_T 1.606 1.00
194_T 197_A 1.603 1.00
152_R 202_R 1.581 1.00
105_E 202_R 1.576 1.00
150_I 167_L 1.57 1.00
191_D 194_T 1.541 0.99
11_V 97_V 1.536 0.99
174_F 196_R 1.515 0.99
31_V 97_V 1.493 0.99
154_C 158_L 1.489 0.99
193_A 196_R 1.386 0.99
15_L 31_V 1.383 0.99
54_P 73_L 1.365 0.99
44_Q 88_I 1.357 0.98
187_A 190_C 1.354 0.98
56_T 59_H 1.313 0.98
184_T 206_A 1.305 0.98
196_R 203_F 1.299 0.98
49_F 52_L 1.277 0.97
102_Q 151_L 1.272 0.97
182_W 206_A 1.267 0.97
89_R 127_D 1.251 0.97
14_E 168_V 1.235 0.97
166_M 184_T 1.23 0.97
32_A 35_L 1.227 0.97
175_R 182_W 1.221 0.96
102_Q 148_A 1.214 0.96
167_L 181_M 1.206 0.96
172_A 195_V 1.19 0.96
183_L 203_F 1.186 0.96
15_L 21_V 1.181 0.95
142_C 170_E 1.181 0.95
95_A 136_I 1.153 0.95
196_R 202_R 1.151 0.95
160_A 163_A 1.149 0.94
183_L 186_I 1.141 0.94
180_K 204_E 1.115 0.93
6_R 188_D 1.114 0.93
53_G 56_T 1.1 0.93
40_H 74_P 1.085 0.92
134_K 166_M 1.081 0.92
173_V 185_E 1.081 0.92
6_R 9_R 1.06 0.91
3_A 6_R 1.042 0.90
4_K 30_M 1.037 0.89
100_G 109_L 1.035 0.89
28_P 99_G 1.028 0.89
158_L 161_Q 1.028 0.89
171_L 194_T 1.024 0.89
172_A 203_F 1.019 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1poiB20.94911000.278Contact Map0.635
3k6mA411000.285Contact Map0.847
4kgbA211000.289Contact Map0.781
2ahuA40.95371000.296Contact Map0.731
1xr4A20.99541000.419Contact Map0.459
2hj0A20.99071000.445Contact Map0.381
3gk7A211000.468Contact Map0.403
3rrlB20.94441000.484Contact Map0.815
3d3uA10.97691000.489Contact Map0.462
3eh7A10.93521000.513Contact Map0.439

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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